Protein Alignment mthl12 and ADGRF2

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001355044.1
• Gene: ADGRF2 / 222611
• HGNCID: 18991
• Length: 708
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 81/501 - (16%)
• Similarity: 156/501 - (31%)
• Gaps: 207/501 - (41%)

  Fly   120 TMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKR----DEYTI-LKDGSILLHTS 179
            |:.:.:|...:::....||..||:.:|:        ..:.|..|    |::.: :.|  :.:||.
Human   239 TIANHILNSKSISNWTFIPDRNSSYILL--------HSVNSFARRLFIDKHPVDISD--VFIHTM 293

  Fly   180 AEILSNDQYCLYPEIYSDFPETIRI------------INRRCYRNVMPGIAQLSVISV----VGF 228
            ...:|.|      .|..:|..::||            |:|...|.| |..:|  |||:    :|.
Human   294 GTTISGD------NIGKNFTFSMRINDTSNEVTGRVLISRDELRKV-PSPSQ--VISIAFPTIGA 349

  Fly   229 ILTLAVYLSV------------------------------------------------------E 239
            ||..::..:|                                                      |
Human   350 ILEASLLENVTVNGLVLSAILPKELKRISLIFEKISKSEERRTQCVGWHSVENRWDQQACKMIQE 414

  Fly   240 KLRNLLGKCLICSLFSMF----------------------------------MEYFIWT------ 264
            ..:..:.||....||:.|                                  :|..:|:
Human   415 NSQQAVCKCRPSKLFTSFSILMSPHILESLILTYITYVGLGISICSLILCLSIEVLVWSQVTKTE 479

  Fly   265 MDYFR-----------LLQSI-----------------CSAAGYMKYFFSMSSYLWF----SVVS 297
            :.|.|           |:..:                 |.||.:..:||.:|.:.|.    .::.
Human   480 ITYLRHVCIVNIAATLLMADVWFIVASFLSGPITHHKGCVAATFFVHFFYLSVFFWMLAKALLIL 544

  Fly   298 FHLWELFTSLNRHEPQYRFLIYNTF---VWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGC 359
            :.:..:|.:|.:     ..|:.:.|   ..|..||..:.:.:      .:|||....|.:.:.
Human   545 YGIMIVFHTLPK-----SVLVASLFSVGYGCPLAIAAITVAA------TEPGKGYLRPEICWL-- 596

  Fly   360 SVKDWNSSSWFYSH-IPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYI 423
               :|:.:....:. ||.:.:...|:|...|..:...:...|...|.:            |:..:
Human   597 ---NWDMTKALLAFVIPALAIVVVNLITVTLVIVKTQRAAIGNSMFQE------------VRAIV 646

  Fly   424 QFVR----LFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNA 465
            :..:    |..::|.:|.....|.:  |...|...|:.:|   |||
Human   647 RISKNIAILTPLLGLTWGFGVATVI--DDRSLAFHIIFSL---LNA 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	21/105 (20%)
ADGRF2	NP_001355044.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900