Protein Alignment mthl12 and ADGRG3

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_005255899.1
• Gene: ADGRG3 / 222487
• HGNCID: 13728
• Length: 596
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 98/471 - (20%)
• Similarity: 166/471 - (35%)
• Gaps: 137/471 - (29%)

  Fly    46 IYEHFEIPANLTGEFDYKELMDGSKVPTEFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKN 110
            ::.|...|.|:|....:.::..|:   |...:..||..:|||...:||          |.
Human   201 VFSHQRPPPNMTLTCVFWDVTKGT---TGDWSSEGCSTEVRPEGTVCC----------CD----- 247

  Fly   111 EIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGSIL 175
              .||..      .||..|||.:        ||..::.|.....|.  ||:....:||     ||
Human   248 --HLTFF------ALLLRPTLDQ--------STVHILTRISQAGCG--VSMIFLAFTI-----IL 289

  Fly   176 LHTSAEILSNDQYCLYPEIYSDFPETIRIINRRCYRNV-----MPGIAQLSVISVVGFILTLAVY 235
            ....:..|.:..:....|  .|.|.. ||.. .|.|.:     :|...|       |....|.
Human   290 YAFLSPGLGHGPHPQQAE--CDLPAG-RIAG-PCERGLERQEKLPPAPQ-------GGAWHLR-- 341

  Fly   236 LSVEKLRN--------LLGKCLICSLFSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLW 292
            ||.|:.::        .||.    |||.:.:.:.:......:...:.|.|.|.:.::|.:.::.|
Human   342 LSRERFKSEDAPKIHVALGG----SLFLLNLAFLVNVGSGSKGSDAACWARGAVFHYFLLCAFTW 402

  Fly   293 FSVVSFHLWELFTSL-NRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGY 356
            ..:.:|||:.|...: |.:...| ||..:...|...|:..:...|.|                .|
Human   403 MGLEAFHLYLLAVRVFNTYFGHY-FLKLSLVGWGLPALMVIGTGSAN----------------SY 450

  Fly   357 FGCSVKDWNSSS-----WFYS----HIPIVILNSFNVIMF----VLTAIYIWKV-----KKGVKS 403
            ...:::|..:.:     ||..    :...:.::.:.:|.|    |:.|:.:||:     ...||.
Human   451 GLYTIRDRENRTSLELCWFREGTTMYALYITVHGYFLITFLFGMVVLALVVWKIFTLSRATAVKE 515

  Fly   404 FAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAF- 467
            ..::.::..|.|           .|..::|.:|.|...|.|...            |||:.|.|
Human   516 RGKNRKKVLTLL-----------GLSSLVGVTWGLAIFTPLGLS------------TVYIFALFN 557

  Fly   468 ---GILI---FVLLIL 477
               |:.|   |.:|.|
Human   558 SLQGVFICCWFTILYL 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	37/162 (23%)
ADGRG3	XP_005255899.1	GPS	213..255	CDD:280071	12/67 (18%)
		7tm_4	355..564	CDD:304433	48/252 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810