Protein Alignment mthl12 and ADGRF4

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001334784.1
• Gene: ADGRF4 / 221393
• HGNCID: 19011
• Length: 695
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 100/506 - (19%)
• Similarity: 176/506 - (34%)
• Gaps: 135/506 - (26%)

  Fly    19 NSSAKIPHCKYDET--INISH---FKRLNDAYIYEHFEIPANLTGEFDYKELMDGSKVPTE---- 74
            |:|..|.:..:.:|  .:|:|   .|.||       |.:..|.|.|    :::...::|.:
Human   229 NNSENIVNELFIQTKGFHINHNTSEKSLN-------FSMSMNNTTE----DILGMVQIPRQELRK 282

  Fly    75 -FPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTLAELNMIP 138
             :||....|....|.:. ...|:..|.|......|...:...:|...:|:|:||         ..
Human   283 LWPNASQAISIAFPTLG-AILREAHLQNVSLPRQVNGLVLSVVLPERLQEIILT---------FE 337

  Fly   139 QYNSTELLILREQFQPCDEIVSLKR--DEYTILKDGSILLHTSAEILSNDQYCLYPEIYSDFPET 201
            :.|.|     |.....|....|.||  ||    |...::|....|:...   |.|..:...|  :
Human   338 KINKT-----RNARAQCVGWHSKKRRWDE----KACQMMLDIRNEVKCR---CNYTSVVMSF--S 388

  Fly   202 IRIINRRCYRNVMPGIAQLSV-ISVVGFILTLAV--------------YLSVEKLRNLLGKCLIC 251
            |.:.::.....|:..|..:.: :|::..:|.|.:              |:....:.|:....|..
Human   389 ILMSSKSMTDKVLDYITCIGLSVSILSLVLCLIIEATVWSRVVVTEISYMRHVCIVNIAVSLLTA 453

  Fly   252 SLFSMFMEYF-IWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYR 315
            :::.:...:| |...||     ::|.|..:..:||.:|.:.|.         ||.:|
Human   454 NVWFIIGSHFNIKAQDY-----NMCVAVTFFSHFFYLSLFFWM---------LFKAL-------- 496

  Fly   316 FLIYNTFV-------------------WC--TAAIPTVVIFSMNQMWENDPGKSEWLPLVGYF-- 357
            .:||...|                   .|  ..|:.||.|        .:|.|       ||.
Human   497 LIIYGILVIFRRMMKSRMMVIGFAIGYGCPLIIAVTTVAI--------TEPEK-------GYMRP 546

  Fly   358 -GCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQT 421
             .|.:...|:.:.....||..::.:.|:|:.::.|:...:...|  |....|......:..||..
Human   547 EACWLNWDNTKALLAFAIPAFVIVAVNLIVVLVVAVNTQRPSIG--SSKSQDVVIIMRISKNVAI 609

  Fly   422 YIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIF 472
                  |..::|.:|... :..|.|.:.|....|...|..:  ..|.||:|
Human   610 ------LTPLLGLTWGFG-IATLIEGTSLTFHIIFALLNAF--QGFFILLF 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	40/193 (21%)
ADGRF4	NP_001334784.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..695

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810