DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl12 and ADGRG5

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_001291305.1 Gene:ADGRG5 / 221188 HGNCID:19010 Length:528 Species:Homo sapiens


Alignment Length:327 Identity:61/327 - (18%)
Similarity:113/327 - (34%) Gaps:140/327 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 IAQLSVISVVGFILTLAVYL--------------SVEKLR-NLLGKCLICSLFSMFMEYFIWTMD 266
            :|.|:.||:||..:::...|              |:.::. ||....|:.::..:....|..:  
Human   245 LAPLTYISLVGCSISIVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMS-- 307

  Fly   267 YFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFV-------- 323
              .:..|.|:|.....::..:|...|.::..|:|:.|   |.|        :||.::        
Human   308 --PVPGSACTALAAALHYALLSCLTWMAIEGFNLYLL---LGR--------VYNIYIRRYVFKLG 359

  Fly   324 ---WCTAAIPTVVIFSMN--------------QMWENDPGKSE----WL--PLV------GYFGC 359
               |...|:  :|:.|::              ..|||..|...    |:  |:|      ||.| 
Human   360 VLGWGAPAL--LVLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGG- 421

  Fly   360 SVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKK--------GVKSFAQHDERNTTCLE 416
                              :.:.||:   |:.|..:|.:::        .|:  |.||.       
Human   422 ------------------LTSLFNL---VVLAWALWTLRRLRERADAPSVR--ACHDT------- 456

  Fly   417 FNVQTYIQFVRLFLIMGASW----------LLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILI 471
                  :..:.|.:::|.:|          ||.|         |.|.||       ||:.:|..:
Human   457 ------VTVLGLTVLLGTTWALAFFSFGVFLLPQ---------LFLFTI-------LNSLYGFFL 499

  Fly   472 FV 473
            |:
Human   500 FL 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
ADGRG5NP_001291305.1 GPS 187..232 CDD:307782
7tmB2_GPR114 245..518 CDD:320559 61/327 (19%)
TM helix 1 247..272 CDD:320559 6/24 (25%)
TM helix 2 281..303 CDD:320559 3/21 (14%)
TM helix 3 315..342 CDD:320559 5/26 (19%)
TM helix 4 355..375 CDD:320559 4/21 (19%)
TM helix 5 409..438 CDD:320559 10/50 (20%)
TM helix 6 451..478 CDD:320559 6/41 (15%)
TM helix 7 482..507 CDD:320559 10/36 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.