DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrl2

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:307 Identity:67/307 - (21%)
Similarity:113/307 - (36%) Gaps:100/307 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSVISVVGF----------ILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQSI 274
            |:||:.||.          |.|...:..::..||.:.|.|..:|   |:..||:.:...:...:|
  Rat   851 LTVITWVGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINL---FIAEFIFLIGIDKTQYTI 912

  Fly   275 -CSAAGYMKYFFSMSSYLWFSVVSFHLW----ELFTSLNRHEPQY---RFLIYNTFVWCTAAIPT 331
             |.....:.:||.::::.|..:....|:    |:|.|....:..|   .:|...|.|..:|||. 
  Rat   913 ACPVFAGLLHFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAID- 976

  Fly   332 VVIFSMNQMWENDPGKSE--WLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYI 394
                      ....|..|  ||.:..||     .|:    |...:..:||  .|:|..|:|...:
  Rat   977 ----------YKSYGTLEACWLHVDNYF-----IWS----FIGPVTFIIL--LNIIFLVITLCKM 1020

  Fly   395 WKVKKGVKSFAQHDERNTTCLEFNVQTY-----------------IQFVR--------LFLIMGA 434
            .|....:|.       :::.|| |:..|                 ..|::        |..::|.
  Rat  1021 VKHSNTLKP-------DSSRLE-NINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFALLCLLGL 1077

  Fly   435 SWLLDQLTRLAEDSHLLL----DTIVLNLTVYLNAAF----GILIFV 473
            :|           |..||    :|:|:   .||..||    |:.||:
  Rat  1078 TW-----------SFGLLFVNEETVVM---AYLFTAFNAFQGLFIFI 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
Adgrl2NP_599235.3 Gal_Lectin 49..129 CDD:396628
OLF 142..398 CDD:413369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462
HormR 469..533 CDD:214468
GAIN 542..764 CDD:406802
GPS 788..840 CDD:197639
7tm_GPCRs 848..1129 CDD:421689 67/307 (22%)
TM helix 1 850..875 CDD:410628 7/23 (30%)
TM helix 2 884..906 CDD:410628 7/24 (29%)
TM helix 3 915..942 CDD:410628 4/26 (15%)
TM helix 4 954..974 CDD:410628 4/19 (21%)
TM helix 5 991..1020 CDD:410628 10/39 (26%)
TM helix 6 1036..1087 CDD:410628 9/61 (15%)
TM helix 7 1091..1116 CDD:410628 8/23 (35%)
Latrophilin 1128..1487 CDD:396778
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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