DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and Adgrg1

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_006530743.1	Gene:	Adgrg1 / 14766	MGIID:	1340051	Length:	718	Species:	Mus musculus

Alignment Length:	451	Identity:	79/451 - (17%)
Similarity:	160/451 - (35%)	Gaps:	158/451 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SNGECSDGVKNEIKLTMLDLTMQDILL---TDPTLAE--LNMIPQ----YNSTELLILREQFQPC 155
            :.|...|..|   :|.::|.:.|.:..   :...|.|  |.::.|    .|.::.::|..|.||.
Mouse   308 TRGRRRDDAK---RLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQHQPQ 369

  Fly   156 DEIVSLK-------------------------RDEYTI-----LKDGSILLHTSAEILSNDQYCL 190
            .:.|:|:                         ||..|.     |...::|:.:|.|:.:..::
Mouse   370 PKNVTLQCVFWVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAVLMVSSTEVEATHKH-- 432

  Fly   191 YPEIYSDFPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYL-SVEKLRNLLGKCLICSLF 254
                               |..::..:.  .|||.:..:.|:|.|| |..|.|:...|..:..|.
Mouse   433 -------------------YLTLLSYVG--CVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLS 476

  Fly   255 SMFMEYFIWTMDYFRLL---------QSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRH 310
            ::|:      :|...||         ::.|..:....:|..::...|..:..::|:.|...
Mouse   477 AVFL------LDVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVE---- 531

  Fly   311 EPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIP 375
                   ::.|:|                     ||....|.:||        |....:..:.:.
Mouse   532 -------VFGTYV---------------------PGYLLKLSIVG--------WGFPVFLVTLVA 560

  Fly   376 IVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNT---TC-LEFNVQTYIQFVRLF------- 429
            :|.:|::..|:..:               .:..||.|   .| :..::.:|:..:.||
Mouse   561 LVDVNNYGPIILAV---------------RRTPERVTYPSMCWIRDSLVSYVTNLGLFSLVFLFN 610

  Fly   430 LIMGASWLLDQLTRLAEDS----HLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486
            |.|.|:.:: |:.||...|    |:|   .:|.|::.|...:.::.|   .....||::::
Mouse   611 LAMLATMVV-QILRLRPHSQNWPHVL---TLLGLSLVLGLPWALVFF---SFASGTFQLVI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	24/147 (16%)
Adgrg1	XP_006530743.1	PLL	60..193	CDD:376013
		GAIN_A	204..251	CDD:376045
		GPS	376..419	CDD:366827	4/42 (10%)
		7tm_GPCRs	431..698	CDD:391938	55/325 (17%)
		TM helix 1	433..458	CDD:341315	7/26 (27%)
		TM helix 2	468..490	CDD:341315	6/27 (22%)
		TM helix 3	501..528	CDD:341315	3/26 (12%)
		TM helix 4	541..561	CDD:341315	4/27 (15%)
		TM helix 5	592..621	CDD:341315	6/29 (21%)
		TM helix 6	629..656	CDD:341315	6/32 (19%)
		TM helix 7	662..687	CDD:341315	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810