DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRG4

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_722576.3	Gene:	ADGRG4 / 139378	HGNCID:	18992	Length:	3080	Species:	Homo sapiens

Alignment Length:	295	Identity:	65/295 - (22%)
Similarity:	109/295 - (36%)	Gaps:	79/295 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVG-----FILTLAV--YLSVEKLR-NLLGKCLI--CSLFSMFMEYFI---WTMDYFRLL 271
            |::|:..|     ..|.:||  |::..||| :...|.||  |:...|....|:   |...:.::
Human  2743 LALITYTGCGISSIFLGVAVVTYIAFHKLRKDYPAKILINLCTALLMLNLVFLINSWLSSFQKV- 2806

  Fly   272 QSICSAAGYMKYFFSMSSYLWFSVVSFHLW-ELFTSLNRHEPQY--RFLIYNTFVWCTAAIPTVV 333
             .:|..|....::|.:.|:.|..:.:.|:: .|....|.:.|.|  :|.:..   |...||...:
Human  2807 -GVCITAAVALHYFLLVSFTWMGLEAVHMYLALVKVFNIYIPNYILKFCLVG---WGIPAIMVAI 2867

  Fly   334 IFSMNQMWENDPGKSEWLPLVGYFG-----CSVKDWNSSSWFYSHIPIV----ILNSFNVIMFVL 389
            ..|:.:            .|.|...     |.:||   .|.||  |.:|    ::...|:.||..
Human  2868 TVSVKK------------DLYGTLSPTTPFCWIKD---DSIFY--ISVVAYFCLIFLMNLSMFCT 2915

  Fly   390 TAIYIWKVKKGV----KSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHL 450
            ..:.:..||..:    :....||.:.|..|.|             ::|.:|          ....
Human  2916 VLVQLNSVKSQIQKTRRKMILHDLKGTMSLTF-------------LLGLTW----------GFAF 2957

  Fly   451 LLDTIVLNLTVYLNAAF----GILIFVL-LILKGS 480
            .....:.|..:||.|.|    |..|||. .::|.|
Human  2958 FAWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKES 2992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
ADGRG4	NP_722576.3	LamG	28..210	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1348
		CytochromB561_N	<1668..>1909	CDD:286826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2109..2141
		GPS	2684..2727	CDD:280071
		7tm_2	2743..2982	CDD:278432	60/283 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3051..3080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810