Protein Alignment mthl12 and ADGRG4

DIOPT Version :10

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_722576.3
• Gene: ADGRG4 / 139378
• HGNCID: 18992
• Length: 3080
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 65/295 - (22%)
• Similarity: 109/295 - (36%)
• Gaps: 79/295 - (26%)

  Fly   220 LSVISVVG-----FILTLAV--YLSVEKLR-NLLGKCLI--CSLFSMFMEYFI---WTMDYFRLL 271
            |::|:..|     ..|.:||  |::..||| :...|.||  |:...|....|:   |...:.::
Human  2743 LALITYTGCGISSIFLGVAVVTYIAFHKLRKDYPAKILINLCTALLMLNLVFLINSWLSSFQKV- 2806

  Fly   272 QSICSAAGYMKYFFSMSSYLWFSVVSFHLW-ELFTSLNRHEPQY--RFLIYNTFVWCTAAIPTVV 333
             .:|..|....::|.:.|:.|..:.:.|:: .|....|.:.|.|  :|.:..   |...||...:
Human  2807 -GVCITAAVALHYFLLVSFTWMGLEAVHMYLALVKVFNIYIPNYILKFCLVG---WGIPAIMVAI 2867

  Fly   334 IFSMNQMWENDPGKSEWLPLVGYFG-----CSVKDWNSSSWFYSHIPIV----ILNSFNVIMFVL 389
            ..|:.:            .|.|...     |.:||   .|.||  |.:|    ::...|:.||..
Human  2868 TVSVKK------------DLYGTLSPTTPFCWIKD---DSIFY--ISVVAYFCLIFLMNLSMFCT 2915

  Fly   390 TAIYIWKVKKGV----KSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHL 450
            ..:.:..||..:    :....||.:.|..|.|             ::|.:|          ....
Human  2916 VLVQLNSVKSQIQKTRRKMILHDLKGTMSLTF-------------LLGLTW----------GFAF 2957

  Fly   451 LLDTIVLNLTVYLNAAF----GILIFVL-LILKGS 480
            .....:.|..:||.|.|    |..|||. .::|.|
Human  2958 FAWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKES 2992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053
		7tmB3_Methuselah-like	220..488	CDD:410632	65/295 (22%)
		TM helix 2	246..268	CDD:410632	7/26 (27%)
		TM helix 3	276..303	CDD:410632	5/27 (19%)
		TM helix 4	316..336	CDD:410632	4/19 (21%)
		TM helix 5	364..394	CDD:410632	8/33 (24%)
		TM helix 6	410..444	CDD:410632	5/33 (15%)
		TM helix 7	449..479	CDD:410632	9/34 (26%)
ADGRG4	NP_722576.3	LamG	28..210	CDD:473984
		Herpes_BLLF1	<290..742	CDD:282904
		DUF5585	916..>1280	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1274..1348
		2A1904	1768..>2089	CDD:273344
		DUF5585	1960..>2240	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2109..2141
		GPS	2683..2727	CDD:460350
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	2685..2734
		Stachel. /evidence=ECO:0000269|PubMed:35418677	2723..2734
		7tmB2_GPR112	2740..3001	CDD:320663	65/295 (22%)
		TM helix 1	2742..2767	CDD:320663	7/23 (30%)
		TM helix 2	2777..2799	CDD:320663	6/21 (29%)
		TM helix 3	2810..2837	CDD:320663	5/26 (19%)
		TM helix 4	2852..2868	CDD:320663	4/18 (22%)
		TM helix 5	2891..2914	CDD:320663	7/24 (29%)
		TM helix 6	2936..2961	CDD:320663	7/47 (15%)
		TM helix 7	2965..2990	CDD:320663	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3051..3080