DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgre1

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_001342651.1 Gene:Adgre1 / 13733 MGIID:106912 Length:931 Species:Mus musculus


Alignment Length:301 Identity:58/301 - (19%)
Similarity:113/301 - (37%) Gaps:82/301 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 SVISVVGFILTLAVYLSVEKLRN-----LLGKCLICSLFSMFMEYFIWTMDYFRLLQSICSAAGY 280
            :|||:|...|.:|.:|....::|     .|..| :|...:..:  |:..:|......:....||:
Mouse   655 TVISLVCLALAIATFLLCRAVQNHNTYMHLHLC-VCLFLAKIL--FLTGIDKTDNQTACAIIAGF 716

  Fly   281 MKYFFSMSSYLWFSVVSFHLW---------ELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVI-- 334
            :.|.| ::.:.|..|.:..|:         ..|:|.|     .:.|....|.:   .:|.:|:  
Mouse   717 LHYLF-LACFFWMLVEAVMLFLMVRNLKVVNYFSSRN-----IKMLHLCAFGY---GLPVLVVII 772

  Fly   335 --------FSM-NQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLT 390
                    :.| |:.|.|......|    .:.|                |:.::.:.|.::...|
Mouse   773 SASVQPRGYGMHNRCWLNTETGFIW----SFLG----------------PVCMIITINSVLLAWT 817

  Fly   391 AIYIWKVKKGVKSFAQHDE--RNTTCLEFNVQTYIQFVRLFLIMGASWLLD--QLTRLAEDSHLL 451
               :|.:::.:.|.:....  ::|..|.|..      :....|:|.||:|.  |:..||      
Mouse   818 ---LWVLRQKLCSVSSEVSKLKDTRLLTFKA------IAQIFILGCSWVLGIFQIGPLA------ 867

  Fly   452 LDTIVLNLTVYLNAAFGILIFVLLILKG----STFKMIMER 488
              :|:..|...:|:..|..||::..|..    ..:|.::.|
Mouse   868 --SIMAYLFTIINSLQGAFIFLIHCLLNRQVRDEYKKLLTR 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
Adgre1NP_001342651.1 EGF_CA 33..63 CDD:238011
EGF_CA 81..115 CDD:214542
EGF_CA 133..172 CDD:214542
EGF_CA 173..>203 CDD:214542
EGF_CA 222..258 CDD:238011
EGF_CA 272..>301 CDD:214542
EGF_CA 319..352 CDD:214542
Cell attachment site. /evidence=ECO:0000255 506..508
GPS 591..640 CDD:197639
7tmB2_EMR 644..906 CDD:320555 57/299 (19%)
TM helix 1 646..671 CDD:320555 6/15 (40%)
TM helix 2 680..702 CDD:320555 4/24 (17%)
TM helix 3 711..738 CDD:320555 7/27 (26%)
TM helix 4 755..775 CDD:320555 4/22 (18%)
TM helix 5 792..815 CDD:320555 4/42 (10%)
TM helix 6 839..864 CDD:320555 8/30 (27%)
TM helix 7 868..893 CDD:320555 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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