Protein Alignment mthl12 and adgrl2b.1

DIOPT Version :10

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_073767727.1
• Gene: adgrl2b.1 / 110437953
• ZFINID: ZDB-GENE-130116-4
• Length: 1467
• Species: Danio rerio
• Alignment Length: 273
• Identity: 60/273 - (21%)
• Similarity: 112/273 - (41%)
• Gaps: 59/273 - (21%)

  Fly   216 GIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQS--ICSAA 278
            ||| :|::.:...|.|...:..::..||.:.|.|..:||...:.:.:.    ..:.:.  :||..
Zfish   854 GIA-VSLVCLAISIFTFCFFRGLQSDRNTIHKNLCINLFIAELLFLVG----INMTEPPIVCSVI 913

  Fly   279 GYMKYFFSMSSYLWFSVVSFHLW----ELFTS-LNRHEPQYR--FLIYNTFVWCTAAIPTVVIFS 336
            ..:.:||.::::.|..:....|:    |:|.| .:|.:..|.  :|.....|..:|||
Zfish   914 AGVLHFFFLAAFSWMCLEGVQLFLMLVEVFESEFSRRKYYYASGYLFPCVVVGISAAI------- 971

  Fly   337 MNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGV 401
              ........|:.||.:..:|     .|:    |...:..:||  .|:|..|:|   ::|:.|..
Zfish   972 --DYKSYGTKKACWLRVDNHF-----IWS----FIGPVTFIIL--LNLIFLVVT---MYKMVKHS 1020

  Fly   402 KSFAQHDERNTTCLEFNVQTYI--QFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLN 464
            .|......|    || ::::::  .|..|.|:. .:|....|  ...||.:::        .||.
Zfish  1021 MSMKPDSSR----LE-SIRSWVFGAFALLCLLC-LTWSFGLL--FLNDSSVIM--------AYLF 1069

  Fly   465 AAF----GILIFV 473
            :.|    |:.|||
Zfish  1070 SIFNTLQGMFIFV 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053
		7tmB3_Methuselah-like	220..488	CDD:410632	57/269 (21%)
		TM helix 2	246..268	CDD:410632	4/21 (19%)
		TM helix 3	276..303	CDD:410632	5/30 (17%)
		TM helix 4	316..336	CDD:410632	5/19 (26%)
		TM helix 5	364..394	CDD:410632	8/29 (28%)
		TM helix 6	410..444	CDD:410632	8/35 (23%)
		TM helix 7	449..479	CDD:410632	7/29 (24%)
adgrl2b.1	XP_073767727.1	None