DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and adgre14

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_021330419.1	Gene:	adgre14 / 108182849	ZFINID:	ZDB-GENE-131120-49	Length:	505	Species:	Danio rerio

Alignment Length:	515	Identity:	97/515 - (18%)
Similarity:	202/515 - (39%)	Gaps:	104/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VTIAKNSSAKIPH--CKYDETINISHFKRLNDAYIYEHFEIPANLT---GEFDYKELMDGSKVP- 72
            |.|..:||:..|:  ..|...:.|::.:.::.  :.:..:..||::   .:.:.:..|.|..|.
Zfish     7 VNIHMSSSSANPNELTSYGNRVLINNEELMST--LVKQTDTSANVSFTLADVEGRVFMVGPHVTL 69

  Fly    73 TEFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTD---PTLAEL 134
            .|.|.|.         .|.|....:::.....::|.::...:.:...||:::|..|   .|...:
Zfish    70 DEIPRLH---------TRNCSIDIDLIGIANNNNGTRSAAVIFLGYNTMENLLKADFFNATNDTV 125

  Fly   135 N---------MIPQYNSTEL-----LILR--EQFQPCDEIVSLKRDEYTILKDGSILLHTSAEI- 182
            |         .:|:..:|.|     ...|  .:|.|......:..:....:.||..:|:|:...
Zfish   126 NTMMSSVISVTLPKTTNTALSKPVNFTFRHIREFDPSGSFSCVYWNISKWIVDGCSVLNTNRSFT 190

  Fly   183 ------LSNDQYCLYPEIYSDFPETIRIINRRCYRNVMPGIAQLSVISV-VGFILTLAVYLSVEK 240
                  ||.  :.|..:..|..||:..::|            .|:|:.| ||.:......|:..:
Zfish   191 VCSCVHLST--FALIMQTRSHPPESDSLLN------------VLNVVCVIVGLLFFSLALLTFTR 241

  Fly   241 LR-----NLLGKCLICSLFSMFMEYFIWTMDYFRLLQS---ICSAAGYMKYFFSMSSYLWFSVVS 297
            .:     |.:.:..||....:....|:.|..:..|::.   :|.....:.:|..:|.::|..:.:
Zfish   242 CQWSPGVNNVARINICISLLLAHLLFLLTQQFLSLIRRQKVLCMLISGLLHFLFLSGFVWMFIEA 306

  Fly   298 FHLWELFTSLNRHEPQYRFLIYNTFVWCTA--AIPTVVIFSMNQMWENDPGKSE-WLPLVGYFGC 359
            ..|:....:|::...|.:.::.|..: |..  |:..||:.....:..|..|..: |:.:
Zfish   307 VLLFICVKNLSQISSQMKNVLRNKLL-CVIGYAVALVVVSISAAVVPNGYGSEKCWIQM------ 364

  Fly   360 SVKDWNSSSWFYSHI-PIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYI 423
                  ...:.:|.: |:.|:.:.|||:|:...   :.:|...|..      |....:.|....:
Zfish   365 ------HKGFIWSFLGPVTIIIALNVILFISIG---FSLKSAFKKL------NADVSQLNQTKIV 414

  Fly   424 QFVRL--FLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVL--LILKG 479
            .|..|  |:::|.||:|...|    :|..:|:.:.|    .||:..|..||::  ::.||
Zfish   415 MFKTLAQFVVLGCSWILGFFT----NSSKVLEILFL----ILNSQQGTFIFLIYCVLNKG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	36/211 (17%)
adgre14	XP_021330419.1	GPS	167..205	CDD:197639	7/39 (18%)
		7tm_GPCRs	214..476	CDD:333717	57/295 (19%)
		TM helix 1	217..241	CDD:320095	7/35 (20%)
		TM helix 2	250..271	CDD:320095	3/20 (15%)
		TM helix 3	285..307	CDD:320095	3/21 (14%)
		TM helix 4	331..347	CDD:320095	4/16 (25%)
		TM helix 5	365..388	CDD:320095	6/22 (27%)
		TM helix 6	412..435	CDD:320095	7/22 (32%)
		TM helix 7	439..464	CDD:320095	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153592at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820