DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and adgrf3a

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_021322955.1 Gene:adgrf3a / 101886922 ZFINID:ZDB-GENE-131121-607 Length:949 Species:Danio rerio


Alignment Length:328 Identity:75/328 - (22%)
Similarity:128/328 - (39%) Gaps:77/328 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 LSNDQYCL------YPEIYSDFPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEK- 240
            :.|...|:      :..:.|...||:..::...|..:  ||:.||:::.:  |:.:.|:.:|.| 
Zfish   624 VDNPTLCICDHNSAFTILMSKNAETLPYMDELTYAGL--GISILSLLACL--IIKVLVWDAVVKS 684

  Fly   241 ----LRNL-LGKCLICSLFSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHL 300
                .|:: |....:|.|.:..|  |:.|.....:..:.||....:|:||.::.:.|...:||.|
Zfish   685 PISNFRHVALFNISLCLLLAHCM--FLTTSKPESIPPNWCSILTLIKHFFFLAVFFWMLCLSFVL 747

  Fly   301 WELFTSLNRHEPQYRF--LIYNTFVW--------CTAAIPTVVIFSMNQMWEND-PGKSE-WLPL 353
                    .|:..|.|  |....|:.        |......|...|.|...|.: ..||. ||..
Zfish   748 --------LHQMIYVFDRLRKKVFLGLSITVGYACPIIAVAVTYISFNNGAEGEYYSKSTCWLTY 804

  Fly   354 VGYFGCSVKDWNSSSWFYSHIP---IVILNSFNVIMFVLTAIYIWKV-KKGVKSFAQHDERNTTC 414
            .|....|:        |...||   ||.:|.|.:      |:.|.|: ...:......||::.  
Zfish   805 KGTLKGSI--------FAFIIPIGAIVFVNLFTL------AVVIMKIATPSISEAKARDEKDV-- 853

  Fly   415 LEFNVQTYIQFVRLFL--IMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGIL-----IF 472
                .::.|:.: :||  ::|.||:|....       |.||..|......:|.:|.|.     :|
Zfish   854 ----AKSMIKTI-VFLSPVLGLSWVLGFFV-------LGLDLTVKPWAALVNYSFTIFNSLQGLF 906

  Fly   473 VLL 475
            :||
Zfish   907 ILL 909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 5/31 (16%)
adgrf3aXP_021322955.1 GPS 604..641 CDD:307782 2/16 (13%)
7tm_GPCRs 649..926 CDD:333717 70/303 (23%)
TM helix 1 652..676 CDD:320095 6/27 (22%)
TM helix 2 691..712 CDD:320095 5/22 (23%)
TM helix 3 723..745 CDD:320095 5/21 (24%)
TM helix 4 766..782 CDD:320095 1/15 (7%)
TM helix 5 805..831 CDD:320095 9/39 (23%)
TM helix 6 855..881 CDD:320095 8/33 (24%)
TM helix 7 890..915 CDD:320095 6/20 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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