DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and adgre13

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_021327151.1	Gene:	adgre13 / 100538238	ZFINID:	ZDB-GENE-150505-3	Length:	303	Species:	Danio rerio

Alignment Length:	281	Identity:	64/281 - (22%)
Similarity:	119/281 - (42%)	Gaps:	52/281 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVGFILTLAVYLSVEKLR----------NLLGKCLICSLFSMFMEYFIWTMDYFRLL--- 271
            |:|::||..|:.| ::.|:..|.          |.:.:..||....:....|:.|..:..|:
Zfish    15 LNVLNVVCVIVGL-LFFSLALLTFAFCQWGPGVNNVARINICISLLLAHLLFLLTQQFLSLIRRQ 78

  Fly   272 QSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTA--AIPTVVI 334
            |.:|.....:.:|..:|.::|..:.:..|:....:|::...|.|.::.|.|: |..  |:..||:
Zfish    79 QMLCEVISGLLHFLFLSGFVWMFIEAVLLFICVKNLSQISSQKRNVLRNIFL-CVIGYAVALVVV 142

  Fly   335 FSMNQMWENDPGKSEWLPLVGYFG--CSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKV 397
                       |.|..:...||..  |.:|......|.:.. |:.::.:.|||:|:...:   .:
Zfish   143 -----------GISAAVVPKGYGSEKCWIKMDKGFIWSFLG-PVTVILALNVILFIGIGV---SL 192

  Fly   398 KKGVKSFAQHDERNTTCLEFNVQTYIQFVRL--FLIMGASWLLDQLTRLAEDSHLLLDTIVLNLT 460
            |...|..      |....:.|....|.|..|  |:::|.||:|...|    :|..:|:.:.|
Zfish   193 KSAFKKL------NADVSQLNQTKIIMFKTLAQFVVLGCSWILGFFT----NSSKVLEILFL--- 244

  Fly   461 VYLNAAFGILIFVL--LILKG 479
             .||:..|..||::  ::.||
Zfish   245 -ILNSQQGTFIFLIYCVLNKG 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
adgre13	XP_021327151.1	7tm_GPCRs	12..274	CDD:333717	64/281 (23%)
		TM helix 1	15..39	CDD:320095	8/24 (33%)
		TM helix 2	48..69	CDD:320095	3/20 (15%)
		TM helix 3	83..105	CDD:320095	3/21 (14%)
		TM helix 4	129..145	CDD:320095	6/27 (22%)
		TM helix 5	163..186	CDD:320095	5/23 (22%)
		TM helix 6	210..233	CDD:320095	8/22 (36%)
		TM helix 7	237..262	CDD:320095	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153592at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010