DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and adgrf8

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_021324214.1 Gene:adgrf8 / 100537224 ZFINID:ZDB-GENE-130531-41 Length:1719 Species:Danio rerio


Alignment Length:463 Identity:90/463 - (19%)
Similarity:150/463 - (32%) Gaps:154/463 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 IKLTMLDL---TMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGS 173
            :.||.:.|   |:...|....||:        |||..:::.:.|.|....:.:......||...:
Zfish  1237 VNLTSIQLSRTTVNSSLSVTSTLS--------NSTTEIVIPQVFGPTTATIIIFTTLDNILPTRN 1293

  Fly   174 ILLHTSAEI-------------------------------LSNDQY--------------CLYPE 193
            |..:.|::|                               |.|.|.              |...:
Zfish  1294 ISNNNSSDISDQRINGDVVVVKVDKTVNNISFAFDITNQSLGNPQCVFWNFNLSAWDSTGCEVKQ 1358

  Fly   194 IYSDFPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFM 258
            :.:|    ..||...|.......|. :|...:...||....|:.|......|..|||       :
Zfish  1359 VGND----SGIITCECNHTTSFSIL-MSPFILDSLILAYITYIGVTISMISLVLCLI-------I 1411

  Fly   259 EYFIWTMDYFRLLQSICSAAG------YMKY--FFSMSSYLWFSVVSFHLWELFTSLNRHEPQYR 315
            |..:|        :|:.||.|      ||::  ..:::..|..:.|.|.:....:.|.:..|..|
Zfish  1412 EAIVW--------RSVTSARGVTVVSSYMRHISLVNIALSLLIANVCFIIGAAISDLEKPTPVGR 1468

  Fly   316 ---------FLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPL---VGYFGCSV------- 361
                     |.....|.|  ..|..:::..|..|......:.:.:.:   ||| |..:       
Zfish  1469 CSPVVFFIHFFYLAVFFW--MLISGMLLLYMTVMVFGQMSRIKMIAISFPVGY-GAPLLIASITV 1530

  Fly   362 ----------------KDWNSSSWFYSH-IPIVILNSFNVIMFVLTAIYIWK-VKKGVKSFAQHD 408
                            .:||.|....:. ||.:.:.:.|:::.|   :.::| :..||.:..|..
Zfish  1531 ASTAGPQNYVSKQACWLNWNESRALLAFVIPALTIVAINLVVLV---VVLYKMLGTGVGAATQPS 1592

  Fly   409 ERNT-----TCLEFNVQTYIQFVRLFLIMGASWLLDQLTRL--AEDSHLLLDTIVLNLTVYLNA- 465
            |:||     .|:.|          |..:.|.:|.....|.|  |...|:|.        ..||| 
Zfish  1593 EKNTFFVVVRCVAF----------LTPLFGLTWGFGIGTMLSSALGVHVLF--------TLLNAF 1639

  Fly   466 -AFGILIF 472
             .|.||:|
Zfish  1640 QGFFILLF 1647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 24/144 (17%)
adgrf8XP_021324214.1 EGF_CA 156..189 CDD:214542
EGF_CA 324..357 CDD:214542
EGF_CA 508..>540 CDD:214542
EGF_CA 673..706 CDD:214542
Ig 899..968 CDD:325142
GPS 1337..1379 CDD:307782 6/45 (13%)
7tm_GPCRs 1387..1660 CDD:333717 63/300 (21%)
TM helix 1 1390..1414 CDD:320095 8/30 (27%)
TM helix 2 1434..1455 CDD:320095 3/20 (15%)
TM helix 3 1470..1492 CDD:320095 4/23 (17%)
TM helix 4 1513..1529 CDD:320095 4/16 (25%)
TM helix 5 1551..1574 CDD:320095 4/22 (18%)
TM helix 6 1598..1623 CDD:320095 6/34 (18%)
TM helix 7 1627..1652 CDD:320095 9/29 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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