DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl12 and gpr157

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001124512.1	Gene:	gpr157 / 100038048	XenbaseID:	XB-GENE-492646	Length:	323	Species:	Xenopus tropicalis

Alignment Length:	180	Identity:	36/180 - (20%)
Similarity:	72/180 - (40%)	Gaps:	28/180 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 VISVVGFILTLAVYLSVEKLRN----LLGKCLICSLFSMFMEYFIWTMDYFRLLQSICSAAGYMK 282
            |:|.:|..|.:..|:..:.||:    ||....:..|.|. :.||...:..|:.....|...|.:.
Frog    24 VLSFLGSALIIVTYILWQDLRSRPRLLLLFLSVADLLSA-LSYFYGVLRNFQDSTWDCVTQGAIS 87

  Fly   283 YFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGK 347
            .|.:.||:.|...|:.:   |:.::.:.:..:...|.......:..:|.|:..|
Frog    88 TFSNTSSFFWTVAVAVY---LYITIVKSQQSFADQIIPWLHLISWGVPLVITLS----------- 138

  Fly   348 SEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKV 397
            :..|..:||....|    |..|.:..|.:.     :.::::|.|..:|::
Frog   139 AVCLKKIGYDASYV----SVGWCWVKIDVE-----DKLLWMLLAGKVWEI 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
gpr157	NP_001124512.1	7tm_GPCRs	17..>192	CDD:391938	36/180 (20%)
		TM helix 1	17..39	CDD:341315	5/14 (36%)
		TM helix 2	48..69	CDD:341315	6/21 (29%)
		TM helix 3	81..103	CDD:341315	6/21 (29%)
		TM helix 4	123..139	CDD:341315	3/26 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I5275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050