Protein Alignment NOC2L and Noc2

DIOPT Version :10

• Sequence 1: NP_056473.3
• Gene: NOC2L / 26155
• HGNCID: 24517
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_610095.1
• Gene: Noc2 / 35386
• FlyBaseID: FBgn0032925
• Length: 766
• Species: Drosophila melanogaster
• Alignment Length: 781
• Identity: 268/781 - (34%)
• Similarity: 434/781 - (55%)
• Gaps: 111/781 - (14%)

Human    33 ENSPQAETREAREAARSPDKPGGSP---SASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSL 94
            :..||. |.|.:...|:|.:....|   ..:.:||....||::|..|||.|||||.||:.||:.|
  Fly    30 KTKPQT-TSETKVTPRNPKQKVAEPVKNGKTTKKGFKKSHKEELEGLKDIDPEFYDFLKNNDKKL 93

Human    95 LNFS--DSDSSEEEEG---------------------PFHSLPDVLEEASEEEDGAEEGEDGDRV 136
            |:|:  |:|..::|||                     .:|.....||.||:|.| .|..|:.|..
  Fly    94 LDFNLLDTDDDDDEEGDEEDKEDTVTKESKDDEDDEEKYHKPSKDLEVASDESD-FEVDEEDDAA 157

Human   137 PRGLKGKKNSVPVTVAMVERWKQAAKQ-RLTPKLFHEVVQAFRAAVATTRGDQESAEANK----- 195
            ..|::      .:|:.::.:|:|...| .::..:..:|:|||.:|:|:...|......||
  Fly   158 AGGIQ------KITLNLLHQWEQQLGQANISIDIVRKVIQAFNSALASISADGADGGENKHNAAA 216

Human   196 FQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSS-PL-----WGKLRVDIKAYL 254
            |:|..:||||.::..|:..|...:.:||          .::|:|| ||     |.|:|..::.||
  Fly   217 FKVVGAAAFNGVIQLCVIHLQPAIIRLL----------GVRPNSSLPLHKHKKWVKVRGCLRYYL 271

Human   255 GSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVIVWSTGEESLRVLAFLVLSR 319
            ...|:||..:|...:|..:|:|:..:....:.|....:.:|||:|::||||:|::||||||.:.:
  Fly   272 TDLIRLVEQVSSPNILGVLLKHLHQMAGMVVPFSALGKTILKRLVVLWSTGDETVRVLAFLCILK 336

Human   320 VCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQL 384
            :.|.::.|.|..|||.||:.||||.||.||..||.|:||:.:|.|:.||:..|:|||.|||||||
  Fly   337 ITRKQQATMLNHVLKAMYLAYVRNSKFVSPNTLPGINFMRRSLVEMFALDLNVSYQHVFLYIRQL 401

Human   385 AIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTA 449
            |||||||:..:||:::|:|||||:::.|.||..:|..:.....||||:|||..:..|.|:|||||
  Fly   402 AIHLRNAVILKKKDSFQAVYNWQFINSLRLWADLLGASANKPQLQPLIYPLVTIATGVIRLIPTA 466

Human   450 RFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQ 514
            :::|||.||::.|..|:..:..::||||.|:|:.:...||||...:|.||:.|:.:|:|:...|.
  Fly   467 QYFPLRFHCLQTLISLAKETNTYVPVLPLIVEVLKSNTFNRKHSAVSMKPVQFTCVLRLNKGQLA 531

Human   515 EKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQE 579
            |..:||.::||:..|.||||..::..:.|.:||:|.|:.:|::|:||:.|||.|:::|||.|:||
  Fly   532 ENGFRDEVIEQVCGLLLEYLAHESTSLAFSDLVVPTVMAIKTYLKECRNANYARKLKQLLEKIQE 596

Human   580 NSAYICSRRQR--VSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLE- 641
            ::.:|..:|.:  |:|.:.:.|||.|||:..|.:.|||.:||:.|.|..:.:.:.:.:..:.:.
  Fly   597 SARFIEQQRGKSSVTFDIKDAQAVAAWEQQLRLKRTPLDVYYASWLKTHETKKRRQAAHTDEINA 661

Human   642 DLNFPEIKR---RKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDE 703
            |.:.|::|:   :.....::|:.:  .:||..:|.:|.| :|.            |...||::||
  Fly   662 DYDVPKLKKLPVKTGVPVRNENGE--VELFPSDSEDEGD-DGL------------HLGSDDDDDE 711

Human   704 EEGEEDSSNSE----------------------DGDPDAEAGLAPGELQQLAQGPEDELEDLQLS 746
            :..||:....|                      :.|.| |||           |..|.::||.|:
  Fly   712 DVQEEEEVEVEHPKAKKAKKEKPEKQKPRPATVEDDYD-EAG-----------GAVDIVKDLDLN 764

Human   747 E 747
            |
  Fly   765 E 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOC2L	NP_056473.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..82		16/51 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..143		17/69 (25%)
		Noc2	327..622	CDD:461023	137/296 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..749		24/102 (24%)
Noc2	NP_610095.1	Noc2	344..641	CDD:461023	137/296 (46%)