DRSC/TRiP Functional Genomics Resources

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Protein Alignment ABCA12 and snu

DIOPT Version :10

Sequence 1:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens
Sequence 2:NP_651628.1 Gene:snu / 43391 FlyBaseID:FBgn0039594 Length:808 Species:Drosophila melanogaster


Alignment Length:488 Identity:123/488 - (25%)
Similarity:207/488 - (42%) Gaps:110/488 - (22%)


- Green bases have known domain annotations that are detailed below.


Human  1321 TNPSASKTSPEYMFSSN----IEPE-----------PKDLTVGVALHGVTKIYGSK----VAVDN 1366
            ::|||..::...|.::|    .:|.           |::....|::....|.||.|    ..::|
  Fly    31 SDPSAIISTDSAMAATNNDGGTQPNAVAAWGAPANGPRNTQAAVSVRHAFKAYGKKKNANQVLNN 95

Human  1367 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTV-RKNMGVCMQHD 1430
            ||:...:|.|..|||.:|.||||.:|.:.|.....||.|||.|....|....| .|.:|...|..
  Fly    96 LNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEI 160

Human  1431 VLFSYLTTKEHLLLYGSIKVPHW----TKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLS 1491
            .|:...:.:|.::.:|      |    ..|::.|.::..|....|.|.: :.|..||||.:|::|
  Fly   161 ALYGEFSIQETMMYFG------WIFGMDTKEILERLQFLLNFLDLPSEK-RLVKNLSGGQQRRVS 218

Human  1492 ISIALIGGSRVVILDEPSTGVDPCSRRSIWD-VISKNKTA-RTIILSTHHLDEAEVLSDRIAFLE 1554
            .::||:....::|||||:.||||..|:|||: ::...|.. :|:|::||:::||. .:..|..:.
  Fly   219 FAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEAR-QAHTIGLMR 282

Human  1555 QGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLK----EDI 1615
            .|.|....||..|         |::.|..|                     |.|.:||    :..
  Fly   283 SGHLLAEESPSVL---------LSIYKCIS---------------------LEEVFLKLSRIQSQ 317

Human  1616 GGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLE 1680
            .|::.:|  .||..:|...::....:|........|..|::....:||.:|       :|..|:.
  Fly   318 KGDVTHV--NFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLIN-------DSNGSIY 373

Human  1681 HLTQKKIG------NSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKR 1739
            .|.|:...      |:|.|...:..|   ..||..    ||.::|           ||.|:|.| 
  Fly   374 TLNQEPYSPPPSRRNNNPNDEESCQD---CYSNLC----KITSKG-----------KIRALLTK- 419

Human  1740 FHHTRRNWKG------LIAQVILPIVFVTTAMG 1766
              :..|.|:.      :.|..::.::....|:|
  Fly   420 --NMLRMWRNVGVMLFIFALPVMQVILFCLAIG 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324
rim_protein 752..2579 CDD:130324 123/488 (25%)
snuNP_651628.1 CcmA 74..311 CDD:440746 81/274 (30%)
YadH 609..807 CDD:440604
Blue background indicates that the domain is not in the aligned region.

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