Protein Alignment ABCA12 and osy

DIOPT Version :10

• Sequence 1: XP_011509253.1
• Gene: ABCA12 / 26154
• HGNCID: 14637
• Length: 2598
• Species: Homo sapiens
• Sequence 2: NP_001034071.1
• Gene: osy / 43186
• FlyBaseID: FBgn0053970
• Length: 777
• Species: Drosophila melanogaster
• Alignment Length: 977
• Identity: 207/977 - (21%)
• Similarity: 353/977 - (36%)
• Gaps: 303/977 - (31%)

Human  1321 TNPSASKTSPEYMFSSNIE---------PEPKDLTV----GVALHGVTKIYGS----KVAVDNLN 1368
            |.|:|:.|:.    :|:::         .:|..|..    .|.:....|:|||    .|.:|.||
  Fly    11 TAPAATATTA----NSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVVLDGLN 71

Human  1369 LNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVY-GKDIKTDLHTVRKNMGVCMQHDVL 1432
            :...:|.|..|||.:|.||||.:|.:.|....::|.|:|. |:............:|...|...|
  Fly    72 MTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIAL 136

Human  1433 FSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALI 1497
            :...|.:|.|:.:|.|..  .:|..:.:..:..||...| .:..|.|..||||.:|::|:::||:
  Fly   137 YGEFTMRETLIYFGIISA--MSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALL 198

Human  1498 GGSRVVILDEPSTGVDPCSRRSIWD---VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLR 1559
            ....::|||||:.||||..|:||||   .|:||... |:|::||::||. ..:..|..|..|.:.
  Fly   199 HEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHT-TVIITTHYIDEC-AQAHMIGLLRGGKML 261

Human  1560 CCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLP 1624
            ...||.||::.:                ||::              |.:.:||
  Fly   262 AEESPDYLRQQY----------------NADS--------------LEDVFLK------------ 284

Human  1625 PFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGN 1689
                      ||:|:    .||...      ..:..:|:...:|..:..|.|:.:.       ..
  Fly   285 ----------LSVLQ----NMGKRR------RSSIAQEIVEQVTVPAISNPALDMS-------DE 322

Human  1690 SNANGISTP--DDLSVSSSNFTDRDDKILTRG----------ERLDGFGLLLKKIMAILIKRFHH 1742
            .:|..||..  |::|:||:    ..|.|.|..          |....|...|.      :.:.||
  Fly   323 QHAAEISGEFGDNISMSSA----ARDPISTTAPAAPPLPPPQEIPTSFWYNLH------VMQSHH 377

Human  1743 TRR-NWKGLI-----AQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTA----FYA 1797
            ... .||..:     ..|:|.||      ||          |.:||....|.......    ..|
  Fly   378 LHALIWKNFLWMMRNVGVMLFIV------GL----------PVVQILLFCYAIGHDPTGLKLAVA 426

Human  1798 NYHPSTEALVSAMWDFPGIDNMCLNTS------DLQCLNKDSLEKWNTSGEPITNFGVCSCSENV 1856
            |:..|.|.:   |..|..:...|..|.      |:...||..:.::.|..|        ...|.|
  Fly   427 NHEMSGEMI---MEQFCPVHTGCNQTMLSCRYLDMLVKNKSMVVQYVTDDE--------MAYEEV 480

Human  1857 QECPKFNYSPPHRRTYSSQVIY-NLT---------GQRVENYLISTANEFVQKRYGGWSFGLPLT 1911
            ::          .|.:::.||. |.|         |:..|:..|.:::..|:..:........|.
  Fly   481 RK----------GRAWAALVIQPNYTASLMERVEDGRYAEDGTIESSDLAVRMDWSNQQISQLLY 535

Human  1912 KDLRFD--------ITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIM 1968
            :||::.        ::....|..|.:|..|.:  |.:..|.|.  ||.        |.|..|:|
  Fly   536 RDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQ--HPVYGYRNP--NFT--------DFAAPGVI- 587

Human  1969 YSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIG---- 2029
                                     |:|:...:|...|....:.|......:.|  ::||.
  Fly   588 -------------------------LTIIFFLAVAVTSGAMLIDRNEGMLERCL--VAGITGPEI 625

Human  2030 -----VTCYWV----TNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATF 2085
                 ||.:.|    |.|:..:.||.    |.:.::           .|:..|..|.:|.|....
  Fly   626 LLSQVVTQFTVMLSQTTFVLIVSFYF----FELTLV-----------GNIWLVVALCILNGLCGM 675

Human  2086 SWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIF 2150
            |:.::::........|  |||.:..|..|  ::...:::.:..                    :|
  Fly   676 SFGFVISCAVDTERTA--TYVAMGSFLPI--VMLCGIIWPIEG--------------------MF 716

Human  2151 PQFCFGYGLIELSQ----QQSVLDFLKAYGVEYP---NETFEMNKLGAMFVALVSQGTMFFSLRL 2208
            |...|....:.|::    .:|:|.  :.:|::.|   |.          |:::.|...:|..|.:
  Fly   717 PLLQFFTAFLPLTKPTESMRSILQ--RGWGIDNPVVYNG----------FISISSWVLVFLVLTI 769

Human  2209 LI 2210
            |:
  Fly   770 LL 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA12	XP_011509253.1	rim_protein	7..>86	CDD:130324
		rim_protein	752..2579	CDD:130324	207/977 (21%)
osy	NP_001034071.1	CcmA	50..285	CDD:440746	81/291 (28%)
		YadH	578..773	CDD:440604	47/281 (17%)