DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA12 and Eato

DIOPT Version :9

Sequence 1:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1855 Identity:462/1855 - (24%)
Similarity:786/1855 - (42%) Gaps:391/1855 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   846 SPLFM-----NSFHLLNQAIPMLQNTLRNPFVQV---FVKFSVGLDAVELLKQI----------- 891
            :|||.     |..:|....:|:|  .:.:.|..|   ::.:||    ..:|.||           
  Fly     6 TPLFFVFLRKNLLYLQRNLLPLL--LICSGFAGVLTAYLHWSV----KPVLHQINQFEAKNEMVL 64

Human   892 -------DELD-ILRLKLENNI-DIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLY 947
                   :||| |....:..|: ||:|.|        .:...::.:|::......||:.|.::..
  Fly    65 RELYFPGNELDYIYYSPISPNVEDIMDLL--------RVDLGIIPERLRPNNNSFEMQLEMEQQC 121

Human   948 KSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPS 1012
            :.:      .|.:..:|..:||.|.           ..|.||.:.|...|.|.:.    .::...
  Fly   122 RGS------CFAIDFHRVPNRGSDR-----------KFRYSLSSNQMRISPRKRF----VNDEEI 165

Human  1013 HNQI----YGRA-FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIV 1072
            ::||    |.|: |:.||..:::..::.|......|:.|..........|..:.||   |...:.
  Fly   166 YHQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLT---YFGTLC 227

Human  1073 LMVAWVVFIAAFVKKLVYEKDLRLHEYMK----MMGVNSCSHFFAWLIESVGFLLVTIVILIIIL 1133
            .::..||.:::||...|.||...|.|::.    |..:|..:.|   ||..|.:.|:.|.:|::. 
  Fly   228 SILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF---LIRFVCYTLLMIFVLVVA- 288

Human  1134 KFGNILPKTNGFILFLY----FSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
                .|.|..|.|.|.|    |..|..|.::.:||||:.|::. ..|.||.|..:|..:.|..:.
  Fly   289 ----YLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLIIPYAFSFVR 348

Human  1195 TVENELSYV----------LKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTS 1249
            :....|::|          |.:|.:            :..:.:.:..|.  .:::.....:.:|.
  Fly   349 SWATSLAFVCFSTNTFLEGLDIFQT------------FSNKRKNREFGA--VDVFRVIKSNSSTM 399

Human  1250 FGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILP-SYWKERFGCAEVKPEKSNGLMF 1313
            |.....|:. .||:|.::..|:..||||..|:..|.:|.:.| :|.|.:.......|..::.::.
  Fly   400 FSVYVVLVF-QSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHAIII 463

Human  1314 TNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITS 1378
            |.:                  ....:...:|..:.                ||||:......||.
  Fly   464 TEL------------------CKKFQTSKRDTLIS----------------DNLNMTINNKEITV 494

Human  1379 LLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL 1443
            |||.|||||||.::|:.||....:|.|.|..   :.|:.:.|..:|.|.||.|..||:|..:||.
  Fly   495 LLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLE 556

Human  1444 LYGSIK------VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRV 1502
            .:..::      ...|..::        ||..||...|::....|||||||:||:.||:.|.:::
  Fly   557 FFAQLRGACRSDARDWADEK--------LKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKI 613

Human  1503 VILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYL 1567
            |||||||:|:|..|||.:||::...:..:.::::||:::|||||.|.|..|..|.|:..|||..|
  Fly   614 VILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLEL 678

Human  1568 KEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSG 1632
            |...|.||.|.|      .:| :.....:.:..:|...:|.|.:. ::....||:..|::.|  .
  Fly   679 KRKSGIGYRLKL------EIN-DFTSREVEIMEIIHHFVPTARVL-NVVNPTVYICLPYAYK--N 733

Human  1633 AYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGIST 1697
            .:..:|..|:....:|.|....::||::|:|||....|..:                     :.|
  Fly   734 CFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQ---------------------VDT 777

Human  1698 PDDLSVSSSNFTDRDDKILTRGERLDGF----GLLLKKIMAILIKRFHHTRRNWKGLIAQVILPI 1758
            ||    .|.|    |..:|...:||...    | |.:..||:..|::......|...:..:.:|.
  Fly   778 PD----GSRN----DAPLLAHYKRLQDHPPHRG-LFQLWMAVFYKKWTFISNEWLYTLIMLCIPF 833

Human  1759 VFVTTA---MGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYAN----YHPSTEALVSAMWDFPGI 1816
            |.|..|   |...:|..:..:.|   :..|..|:.   ..|.:    :|...|..:....:..||
  Fly   834 VCVFGAILVMHAMSLVENEEALP---LKLSQMGSG---VIYVHNPTGHHAHLEQQLRQQIELNGI 892

Human  1817 DNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLT 1881
            ....::......:..:||:...               :|:.:             :..|||    
  Fly   893 TAKTMHLRGSNDVKNESLDLQR---------------DNLAD-------------FLEQVI---- 925

Human  1882 GQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNS 1946
                          .:...|||.              .|.....|: :::|....|||....:|.
  Fly   926 --------------GIIDMYGGG--------------RGTSDTPTI-EIFYSGNRYHSSVELINL 961

Human  1947 LNNFLLRVNM--SKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL-VALSILMGYSVTTASFV 2008
            :::.:|::..  |:.|.....|..:      |.|...:.:.....|: :.:...|.|      |:
  Fly   962 VDSAMLKLGRPESEIDTTYVPIRRF------VSDISPSRLEYYAVIVPIGMFFFMFY------FI 1014

Human  2009 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPA-FYSENNLGA 2072
            :...||:....||||.:|..   .||..:|.:||:. |:.|..::..:....:|: .|:...|..
  Fly  1015 SLPFREYANGFKQLQTMSRF---TYWFAHFTFDMLI-LIFVCVALFSLQSLMMPSELYTTAELKV 1075

Human  2073 VSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLE 2137
            :.|.:..:|.:....:|.|...|.... ...||:.:.|.  :::|..|..       ..|...::
  Fly  1076 IVLSIFFYGCSYLPILYALGNNFKSIS-TISTYLLLMLI--VSAIAPLIT-------SSNAAAMK 1130

Human  2138 LISETLKRIFLIF-PQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGT 2201
            | .|| |..||.| |.|       .|:.|..::           ||.|...:..|:...|:||.|
  Fly  1131 L-HET-KIAFLCFLPDF-------NLNHQFRII-----------NENFITRRHPALIKGLISQDT 1175

Human  2202 MF------------FSLRLLINESLIKKLR------LFFR-KFNSSHVRET--IDEDEDVRAERL 2245
            .|            |...:|.::.|.:::.      .|.| |:||:....:  |.|.:|...|..
  Fly  1176 FFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEK 1240

Human  2246 RVESGAAEFDLVQ---------LYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTT 2301
            ||.      ||::         ::.|.|.|    ...:||:.:|.....|||||||||||||||:
  Fly  1241 RVT------DLIKDPLNDHSLIVHNLRKRY----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTS 1295

Human  2302 IFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPE 2366
            .|:|:..::....|.|.|:. .....|...:....|||||.|||:..:|.|:.||:.|.:.|:..
  Fly  1296 TFQMIAANLPLDGGTIRIKG-ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSR 1359

Human  2367 K------DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDP 2425
            :      ..||.|...|.::||..::.......|.||||||..|:|:||.|:::|||||::|:||
  Fly  1360 RRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDP 1424

Human  2426 KSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVK 2490
            .|:|.||:.|.:......:|:||||||:|||.||.|||||.:|||:|:.::..:|..  .|||:|
  Fly  1425 ISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIK 1487

Human  2491 VHLK---NNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGV--ANIFDLLET---NKT 2547
            :.:|   ..::.:.|:|..::..||...|::.|...|.|.|......|  :::|.:.|.   ::.
  Fly  1488 LKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRL 1552

Human  2548 ALNITNFLVSQTTLEEVFINFAKDQKSYETADTSS 2582
            :..:.::.|::.|||::|:.|.::.||..|:..:|
  Fly  1553 SALVADYSVNECTLEDIFLKFEREAKSQSTSRQTS 1587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA12XP_011509253.1 ABC2_membrane_3 <1026..1270 CDD:289468 56/261 (21%)
ZnuC 1349..1573 CDD:224046 83/229 (36%)
ABC_subfamily_A 1353..1568 CDD:213230 81/220 (37%)
ABC2_membrane_3 <1916..2177 CDD:289468 56/265 (21%)
ABC_subfamily_A 2257..2480 CDD:213230 93/237 (39%)
CcmA 2262..2570 CDD:224054 117/321 (36%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 42/149 (28%)
CcmA 460..767 CDD:224054 107/361 (30%)
ABC_subfamily_A 461..679 CDD:213230 83/262 (32%)
ABC2_membrane_3 <937..1117 CDD:289468 41/199 (21%)
ABC_subfamily_A 1255..1479 CDD:213230 93/228 (41%)
drrA 1262..1573 CDD:130256 115/317 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148332
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

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