Protein Alignment ABCA12 and Eato

DIOPT Version :10

• Sequence 1: XP_011509253.1
• Gene: ABCA12 / 26154
• HGNCID: 14637
• Length: 2598
• Species: Homo sapiens
• Sequence 2: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Alignment Length: 1855
• Identity: 462/1855 - (24%)
• Similarity: 786/1855 - (42%)
• Gaps: 391/1855 - (21%)

Human   846 SPLFM-----NSFHLLNQAIPMLQNTLRNPFVQV---FVKFSVGLDAVELLKQI----------- 891
            :|||.     |..:|....:|:|  .:.:.|..|   ::.:||    ..:|.||
  Fly     6 TPLFFVFLRKNLLYLQRNLLPLL--LICSGFAGVLTAYLHWSV----KPVLHQINQFEAKNEMVL 64

Human   892 -------DELD-ILRLKLENNI-DIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLY 947
                   :||| |....:..|: ||:|.|        .:...::.:|::......||:.|.::..
  Fly    65 RELYFPGNELDYIYYSPISPNVEDIMDLL--------RVDLGIIPERLRPNNNSFEMQLEMEQQC 121

Human   948 KSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPS 1012
            :.:      .|.:..:|..:||.|.           ..|.||.:.|...|.|.:.    .::...
  Fly   122 RGS------CFAIDFHRVPNRGSDR-----------KFRYSLSSNQMRISPRKRF----VNDEEI 165

Human  1013 HNQI----YGRA-FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIV 1072
            ::||    |.|: |:.||..:::..::.|......|:.|..........|..:.||   |...:.
  Fly   166 YHQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLT---YFGTLC 227

Human  1073 LMVAWVVFIAAFVKKLVYEKDLRLHEYMK----MMGVNSCSHFFAWLIESVGFLLVTIVILIIIL 1133
            .::..||.:::||...|.||...|.|::.    |..:|..:.|   ||..|.:.|:.|.:|::.
  Fly   228 SILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF---LIRFVCYTLLMIFVLVVA- 288

Human  1134 KFGNILPKTNGFILFLY----FSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
                .|.|..|.|.|.|    |..|..|.::.:||||:.|::. ..|.||.|..:|..:.|..:.
  Fly   289 ----YLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLIIPYAFSFVR 348

Human  1195 TVENELSYV----------LKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTS 1249
            :....|::|          |.:|.:            :..:.:.:..|.  .:::.....:.:|.
  Fly   349 SWATSLAFVCFSTNTFLEGLDIFQT------------FSNKRKNREFGA--VDVFRVIKSNSSTM 399

Human  1250 FGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILP-SYWKERFGCAEVKPEKSNGLMF 1313
            |.....|:. .||:|.::..|:..||||..|:..|.:|.:.| :|.|.:.......|..::.::.
  Fly   400 FSVYVVLVF-QSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHAIII 463

Human  1314 TNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITS 1378
            |.:                  ....:...:|..:.                ||||:......||.
  Fly   464 TEL------------------CKKFQTSKRDTLIS----------------DNLNMTINNKEITV 494

Human  1379 LLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL 1443
            |||.|||||||.::|:.||....:|.|.|..   :.|:.:.|..:|.|.||.|..||:|..:||.
  Fly   495 LLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLE 556

Human  1444 LYGSIK------VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRV 1502
            .:..::      ...|..::        ||..||...|::....|||||||:||:.||:.|.:::
  Fly   557 FFAQLRGACRSDARDWADEK--------LKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKI 613

Human  1503 VILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYL 1567
            |||||||:|:|..|||.:||::...:..:.::::||:::|||||.|.|..|..|.|:..|||..|
  Fly   614 VILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLEL 678

Human  1568 KEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSG 1632
            |...|.||.|.|      .:| :.....:.:..:|...:|.|.:. ::....||:..|::.|  .
  Fly   679 KRKSGIGYRLKL------EIN-DFTSREVEIMEIIHHFVPTARVL-NVVNPTVYICLPYAYK--N 733

Human  1633 AYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGIST 1697
            .:..:|..|:....:|.|....::||::|:|||....|..:                     :.|
  Fly   734 CFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQ---------------------VDT 777

Human  1698 PDDLSVSSSNFTDRDDKILTRGERLDGF----GLLLKKIMAILIKRFHHTRRNWKGLIAQVILPI 1758
            ||    .|.|    |..:|...:||...    | |.:..||:..|::......|...:..:.:|.
  Fly   778 PD----GSRN----DAPLLAHYKRLQDHPPHRG-LFQLWMAVFYKKWTFISNEWLYTLIMLCIPF 833

Human  1759 VFVTTA---MGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYAN----YHPSTEALVSAMWDFPGI 1816
            |.|..|   |...:|..:..:.|   :..|..|:.   ..|.:    :|...|..:....:..||
  Fly   834 VCVFGAILVMHAMSLVENEEALP---LKLSQMGSG---VIYVHNPTGHHAHLEQQLRQQIELNGI 892

Human  1817 DNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLT 1881
            ....::......:..:||:...               :|:.:             :..|||
  Fly   893 TAKTMHLRGSNDVKNESLDLQR---------------DNLAD-------------FLEQVI---- 925

Human  1882 GQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNS 1946
                          .:...|||.              .|.....|: :::|....|||....:|.
  Fly   926 --------------GIIDMYGGG--------------RGTSDTPTI-EIFYSGNRYHSSVELINL 961

Human  1947 LNNFLLRVNM--SKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL-VALSILMGYSVTTASFV 2008
            :::.:|::..  |:.|.....|..:      |.|...:.:.....|: :.:...|.|      |:
  Fly   962 VDSAMLKLGRPESEIDTTYVPIRRF------VSDISPSRLEYYAVIVPIGMFFFMFY------FI 1014

Human  2009 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPA-FYSENNLGA 2072
            :...||:....||||.:|..   .||..:|.:||:. |:.|..::..:....:|: .|:...|..
  Fly  1015 SLPFREYANGFKQLQTMSRF---TYWFAHFTFDMLI-LIFVCVALFSLQSLMMPSELYTTAELKV 1075

Human  2073 VSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLE 2137
            :.|.:..:|.:....:|.|...|.... ...||:.:.|.  :::|..|..       ..|...::
  Fly  1076 IVLSIFFYGCSYLPILYALGNNFKSIS-TISTYLLLMLI--VSAIAPLIT-------SSNAAAMK 1130

Human  2138 LISETLKRIFLIF-PQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGT 2201
            | .|| |..||.| |.|       .|:.|..::           ||.|...:..|:...|:||.|
  Fly  1131 L-HET-KIAFLCFLPDF-------NLNHQFRII-----------NENFITRRHPALIKGLISQDT 1175

Human  2202 MF------------FSLRLLINESLIKKLR------LFFR-KFNSSHVRET--IDEDEDVRAERL 2245
            .|            |...:|.::.|.:::.      .|.| |:||:....:  |.|.:|...|..
  Fly  1176 FFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEK 1240

Human  2246 RVESGAAEFDLVQ---------LYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTT 2301
            ||.      ||::         ::.|.|.|    ...:||:.:|.....|||||||||||||||:
  Fly  1241 RVT------DLIKDPLNDHSLIVHNLRKRY----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTS 1295

Human  2302 IFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPE 2366
            .|:|:..::....|.|.|:. .....|...:....|||||.|||:..:|.|:.||:.|.:.|:..
  Fly  1296 TFQMIAANLPLDGGTIRIKG-ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSR 1359

Human  2367 K------DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDP 2425
            :      ..||.|...|.::||..::.......|.||||||..|:|:||.|:::|||||::|:||
  Fly  1360 RRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDP 1424

Human  2426 KSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVK 2490
            .|:|.||:.|.:......:|:||||||:|||.||.|||||.:|||:|:.::..:|..  .|||:|
  Fly  1425 ISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIK 1487

Human  2491 VHLK---NNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGV--ANIFDLLET---NKT 2547
            :.:|   ..::.:.|:|..::..||...|::.|...|.|.|......|  :::|.:.|.   ::.
  Fly  1488 LKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRL 1552

Human  2548 ALNITNFLVSQTTLEEVFINFAKDQKSYETADTSS 2582
            :..:.::.|::.|||::|:.|.::.||..|:..:|
  Fly  1553 SALVADYSVNECTLEDIFLKFEREAKSQSTSRQTS 1587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA12	XP_011509253.1	rim_protein	7..>86	CDD:130324
		rim_protein	752..2579	CDD:130324	461/1850 (25%)
Eato	NP_001036360.1	rim_protein	<169..1591	CDD:130324	423/1657 (26%)