DRSC/TRiP Functional Genomics Resources

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Protein Alignment ABCA12 and Abca3

DIOPT Version :10

Sequence 1:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens
Sequence 2:NP_608445.2 Gene:Abca3 / 33103 FlyBaseID:FBgn0031170 Length:1714 Species:Drosophila melanogaster


Alignment Length:1864 Identity:540/1864 - (28%)
Similarity:887/1864 - (47%) Gaps:350/1864 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   809 ILYAPYNPVTKAIMEKSNVTL--RQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPF 871
            :.|:|.|||.|.::|::..:|  .::.|....:|..:|                    ...:|.|
  Fly   105 LCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLELD--------------------TVSKNAF 149

Human   872 VQVFVKFSVGLDAVELLKQIDELD-----ILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQ 931
            ..  |:|.   ||...|.:.|.|.     .||...|           |.:.|:.|::..|     
  Fly   150 AG--VQFD---DAWANLTENDPLPNDFHFALRFPAE-----------LRTATIAIANTWL----- 193

Human   932 AAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTR 996
                       ..||:.:.:|.|      |.|    .|.|.|.:  ||                .
  Fly   194 -----------TMRLFPTIDLTG------PRN----EGDDDGGI--PP----------------G 219

Human   997 SLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIA-VQVQAIPYPCFMKDN 1060
            .||                   ..|:.||.|:..|.:..::|  .|::. |.::..|:|.::.|.
  Fly   220 YLR-------------------EGFLPLQHSLSMAYLRQKSG--EQDLPNVVMKRYPFPAYIFDP 263

Human  1061 FLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVT 1125
            .|..:|..:.::::::::.......|.:..||:.:|.|.||:||:::..|:.||.::|...|.::
  Fly   264 LLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTIS 328

Human  1126 IVILIIILKFG-----NILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYII 1185
            .:::.|::|..     .:|...|...|..:...|..|.|...::::.||:..:.||.:..||:.|
  Fly   329 AILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFI 393

Human  1186 AFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSF 1250
            |:.|:...:...::||...|:..||:|.||..:..:.|..:|..|.||||.|.:|....|||.:.
  Fly   394 AYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTL 458

Human  1251 GWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYW---KERFGCAEVKPEKSNGLM 1312
            |.:..::|....||.:|..||..|.||::|:..||.||....:|   :|..|..::    .||  
  Fly   459 GAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDI----PNG-- 517

Human  1313 FTNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHIT 1377
                .::..:|.|.:|          |||.|.  :|:.:..:.|.:|:|:.|..|::|.:|..||
  Fly   518 ----HVEQRDPKAFET----------EPEGKH--IGLQMRHLKKRFGNKMVVKGLSMNMFEDEIT 566

Human  1378 SLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHL 1442
            .|||.||||||||||||||:|..::||..:.|.||:|::...|.::|:|.||:|||..::...|:
  Fly   567 VLLGHNGAGKTTTISMLTGMFPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHI 631

Human  1443 LLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDE 1507
            ..:..:|  ....|.:.:||.:.||...|....:.....||||||||||:..||.|.::||:.||
  Fly   632 RFFSRMK--GLRGKAVEQEVAKYLKMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDE 694

Human  1508 PSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1572
            ||:|:||.:||.:||::.:.|..||::|:||.:|||:||.||||.:..|.|:|.|:.|:||:.:|
  Fly   695 PSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYG 759

Human  1573 DGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSL 1637
            .||.|...|:..        |:|..|||::..::|....:.|||.||.|.||   ...|..:..:
  Fly   760 SGYRLICVKRDD--------CETNEVTALLNKYIPGLKPECDIGAELSYQLP---DSASAKFEEM 813

Human  1638 LRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLS 1702
            ...|:....:|::..||:..|::||||:.:..|......:..:|    :|.|..:......|:.|
  Fly   814 FGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNTGNIKDQH----EIMNGGSGFRGEDDNES 874

Human  1703 VSSSNFTDRDDKILTRGER-LDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMG 1766
            |.|       |.|.:...| |.|..||..:..|:|:|:|.:|.||...|:.|.|:|:.||...: 
  Fly   875 VQS-------DGIFSENRRLLQGLQLLSNQWKAMLLKKFLYTWRNKLLLLIQNIMPVFFVVVTI- 931

Human  1767 LGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCLNK 1831
              .:..:..::.|::                   |.|.:|.    .:| :....|:.|::|    
  Fly   932 --LIIKTQGTFQELK-------------------PITISLT----QYP-LAVTVLDRSNVQ---- 966

Human  1832 DSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTG-QRVENYLISTANE 1895
                  |.:|..|.|              |:.   ...|:|.|.....||| |..|:|:      
  Fly   967 ------NGTGYEIAN--------------KYE---DLARSYGSNYGLELTGTQGFEDYI------ 1002

Human  1896 FVQKRYGGWSFGLPLTKDLRFDITG---VPANRTLAKV--WYDPEGYHSLPAYLNSLNNFLLRVN 1955
                        |.|.|.::..|..   |.|..|.:|:  |.:.:..|:.|..:|.::|.:    
  Fly  1003 ------------LDLGKTIQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAI---- 1051

Human  1956 MSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL---------VALSILMGYSVTTASFVTYV 2011
            ..|...:...|.:.:.|.|       .|.|:|:..|         :|.::.......::.::.::
  Fly  1052 ADKLFGSSVKIQVTNAPLP-------YTTSTLLSQLSTGNNLGTQLASNLCFCMCFVSSIYILFL 1109

Human  2012 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLL 2076
            ::|.:::||.||.:.|:.|..:|::.||.|...|:|.....:..|..|:.....:...||...||
  Fly  1110 IKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLL 1174

Human  2077 LLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGIN---SIVSLSVVYFLSKEKPNDPTLEL 2138
            |||||:|...::|:::..|.|....|.....||:|.|:.   .:|.:|...|.:|:         
  Fly  1175 LLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKD--------- 1230

Human  2139 ISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYP-------------NETFEMNKLG 2190
            .::.|..||.|||.|.....|.::....:..:.....|...|             ...|...:.|
  Fly  1231 TADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPG 1295

Human  2191 AM--FVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDE----------DEDVRAE 2243
            .:  .|.:...|.:||.:.:::...||.:  |.|:      :|:.|.:          |:||..|
  Fly  1296 VLPETVYMAVTGVVFFLIIIVLEFRLINE--LMFK------IRQLISKPPPPPTEGQLDDDVANE 1352

Human  2244 RLRV----ESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFK 2304
            |.|:    .:..|..:|| |..:||.|    .:.:|||.:|:.:...|||||||||||||||.||
  Fly  1353 RERILQMSSNELATKNLV-LDRVTKYY----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFK 1412

Human  2305 MLTGDIIPSSGNILIRNKTGSL-GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKD 2368
            |:|||...|||...::..  || .:::|...::|||||.|||.|.:|..|.|..:..:.|:.|..
  Fly  1413 MMTGDERISSGAAYVQGL--SLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFCMLRGVQESR 1475

Human  2369 IKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWK 2433
            |::....|.:....|...|:.|...|.|.|||||||:|:||.||::.||||::||||.::|.||.
  Fly  1476 IRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWN 1540

Human  2434 IISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNN-- 2496
            ::.....:..|::||||||||||||||||||||||:|:||||.||:|::|.:|..:|:.::.|  
  Fly  1541 MVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLE 1605

Human  2497 -------------------------KVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVA 2536
                                     :..::.:.:|::..:|.:.|::::..:|.:::|:|....:
  Fly  1606 ALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWS 1670

Human  2537 NIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADT 2580
            .||.|:|:|:..||:.::.||||||||:|:.|||    |:..||
  Fly  1671 RIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAK----YQREDT 1710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324
rim_protein 752..2579 CDD:130324 538/1861 (29%)
Abca3NP_608445.2 rim_protein <137..1708 CDD:130324 529/1828 (29%)
Blue background indicates that the domain is not in the aligned region.

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