DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA12 and abt-2

DIOPT Version :10

Sequence 1:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens
Sequence 2:NP_490949.3 Gene:abt-2 / 171782 WormBaseID:WBGene00000020 Length:2146 Species:Caenorhabditis elegans


Alignment Length:2807 Identity:671/2807 - (23%)
Similarity:1059/2807 - (37%) Gaps:926/2807 - (32%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPST 65
            |...:.||..|:||..|..:||..|..|.::.|.|:|||:|:.|||....|.|.|:...:.:.|.
 Worm    38 MVGFWRQLNFLLWKCVLVRRRQKFWLAVELIVPCILFIIIALVRTKDFSEASPQCHYDSKGMLSA 102

Human    66 GFFPFLQTLLCDTDSKCKDTPYGPQDLLRRKGIDDALFKDSEILRKSSNLDKDSSLSFQSTQVPE 130
            |..||:.:..|...::|...|                                            
 Worm   103 GVLPFIHSFFCSFSNRCNAAP-------------------------------------------- 123

Human   131 RRHASLATVFPSPSSDLEIPGTYTFNGSQVLARILGLEKLLKQNSTSEDIRRELCDSYSGYIVDD 195
                                             ..|.||....|...|..|.|       .|:.|
 Worm   124 ---------------------------------TTGDEKHFLFNDDGEHTRNE-------SIIVD 148

Human   196 AFSWT-----FLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSDPNNQKIVFQEIVRMLSFFSQ 255
            |..::     ::|.|. .||            ::|.|..:::......:.:....|||:...|.:
 Worm   149 AIYYSSLQLRWIGNNP-KKF------------EDLTKGAAEIVHWLAGKSLQSTAIVRLGDLFDE 200

Human   256 VQEQKAVWQLLSSFPNVFQNDTSLSNLFDVLRKANSVLLVVQKVYPRFATNEGFRTLQKSVKHL- 319
                           .:.||.|.:.|... |:...:..|:..::.|  ...|.|:||:..:... 
 Worm   201 ---------------PIRQNLTKVLNTTG-LKMETAEKLLNARLEP--GAIETFQTLRTEISFTD 247

Human   320 LYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLAAQLLILENFEDAL---LNISANSPYIPYLACV 381
            |:..::|...|.......::.:.||.|:.|.           :|.|   |:::....:..|::.|
 Worm   248 LFFSENPLFCDERMFESTFSFEKGQELTNSE-----------KDELCSVLSLTTLMDFSGYMSEV 301

Human   382 RNVTDSLARGSPENLRLLQSTIRFKKSFLRNGSYEDYFPPVPEVLKSKLSQLRNLTELLCESETF 446
            |..|.|..|.:|           |..||                                     
 Worm   302 RLPTLSRLRVTP-----------FISSF------------------------------------- 318

Human   447 SLIEKSCQLSDMSFGSLCEESEFDLQLLEAAELGTEIAASLLYHDNVISKKVRDLLTGDPSKINL 511
                               :|.|:..|:.|.:.|                             |.
 Worm   319 -------------------QSVFEPTLIFAQKYG-----------------------------NY 335

Human   512 NMDQFLEQALQMNYLENITQLIPIIEAMLHVNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMS 576
            :.||.                                      ||.:|     ..||.|.|.   
 Worm   336 STDQL--------------------------------------LLALF-----CGEDPRATI--- 354

Human   577 NRTIDKLLAIPIPDNRAEIISQVFWLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTLL 641
            .:||:       |::              |.|:.||                             
 Worm   355 EQTIN-------PNS--------------DKNVDTP----------------------------- 369

Human   642 HYLNIYNFTYKVFFPRKDQKPVEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLT 706
                                                          .:|:|  ||:         
 Worm   370 ----------------------------------------------FEKLR--KQV--------- 377

Human   707 QAMYRSNRMNTPQGSFSTISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKY 771
                                         .:::..:.|..::.|.:....               
 Worm   378 -----------------------------IKFIQTVTPGKEQEKNSTCTP--------------- 398

Human   772 GIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELR 836
             :|.:....|.||...|:..         ::..|.|.||..|.||||:.::::.|:.||.:..||
 Worm   399 -VPHHQDMNCSSLESPILMK---------VREALSGYILVTPDNPVTRRVVDRLNIPLRDIEHLR 453

Human   837 EKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKL 901
            .....:...:..|.:..| .:...|..|..|.  |::|:                        |.
 Worm   454 NLLYTYPSDALEFQDRLH-ASDLWPASQKLLH--FIKVY------------------------KN 491

Human   902 ENNIDIIDQLNT-------------------LSSLTVNI-------SSCVLYDRIQAAKTIDEME 940
            ..|     ||||                   ..:.|.||       :.|.|.||.:......|:|
 Worm   492 GQN-----QLNTRTIHFFLEHLFAPSSDEYSFGTYTKNITEIANKYTGCFLLDRFRFVTDEKELE 551

Human   941 REAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAP 1005
            ..|..|..:::.|..::|.:.||.:...|:.:          |.||...:...:|.|.......|
 Worm   552 TNAVCLMDTHQYFTGIVFNIDSNATEFDGFTT----------YKIRHYPEMVDSTTSFMDSKSNP 606

Human  1006 GPHNSPSHNQIY-GRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSL 1069
            ...:.|..:..| ...|.:||:||:|||:...|.:....:.|..|..||||.:||.|  :|:..:
 Worm   607 FSRDKPLIDLKYITFGFSFLQESIDRAIMSELTNQTDANLGVYAQQEPYPCTVKDTF--NVALFM 669

Human  1070 PIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 1134
            |:.|:::::...|..||.:||||:.::.|.|:.||:....||.:|.:.|:....::::|:.||.|
 Worm   670 PLFLLISFIFPSALLVKNIVYEKEQKIKEQMRAMGLGDAVHFISWGLISLVLNFISVLIISIISK 734

Human  1135 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVT---- 1195
            ...|...|:..:|......:.||.||||...|..|.|.|||.....:::.:.|.||.:|.|    
 Worm   735 VAKIFDYTDYTLLLFVLILFLFSSIAMSIFFSTLFTNANIATAATCVLWFVFFIPFQLLRTDRIS 799

Human  1196 --VENELSYVLKVFMSLLSPTAFSYASQYIARYE--EQGIGLQWENMY--TSPVQDDTTSFGWLC 1254
              ..|.:|.:       |.|||..:..:.:..:.  |:.   .|.:::  .:||...:..   ||
 Worm   800 SPTFNRISLI-------LPPTAMGHCFKLLESFNAMERA---TWSDLWEMNNPVLGISVE---LC 851

Human  1255 CLIL-ADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMM 1318
            .::| .|:.::.::|||:..|.||.:|:..|.:||....||....        ..|.:.|.:...
 Worm   852 MIMLVVDTAVFLILAWYISAVAPGDFGVRQPLWFPFTLKYWAPGL--------YKNRVEFVDDEH 908

Human  1319 QNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLG 1381
            .:|.|:          |.:.:.||.:||:.|.::.::|:|  |:| |:|.|||..|||.||.|||
 Worm   909 FDTIPN----------SDSFDSEPTNLTLAVHINSMSKVYENGTK-ALDCLNLRLYEGQITGLLG 962

Human  1382 PNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYG 1446
            .||||||||:|:|.||:..|:||..:|.:||:|||..||..:|:|.||:||||:||..|.|.|:.
 Worm   963 HNGAGKTTTMSILCGLYAPSSGTAKIYQRDIRTDLRRVRDVLGICPQHNVLFSHLTVSEQLRLFA 1027

Human  1447 SIK-VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPST 1510
            ::| ||   ..:|..:|...|....|....:|...||||||||:|.|.||.|||||.||||||:.
 Worm  1028 ALKGVP---DSELTSQVDEILASVSLTEKANKLASTLSGGMKRRLCIGIAFIGGSRFVILDEPTA 1089

Human  1511 GVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGY 1575
            |||..:|:.||.::.:||..|||:|||||:|||:|||||||.|.|.                   
 Worm  1090 GVDVTARKDIWKLLQRNKEGRTILLSTHHMDEADVLSDRIAILSQD------------------- 1135

Human  1576 HLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRA 1640
                                              :.|.|:                         
 Worm  1136 ----------------------------------FEKPDL------------------------- 1141

Human  1641 LDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSS 1705
                                                                             
 Worm  1142 ----------------------------------------------------------------- 1141

Human  1706 SNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTL 1770
                            |||..|:.:...|:|:.|.::|.::.:..:.|||:|: |:.....|..|
 Worm  1142 ----------------LDGKRLIFQHFYALLVCRINYTLKSKRTFLFQVIIPL-FLLALAELFVL 1189

Human  1771 RNSSNSYPEIQIS--PSLYGTS---EQTAFYANYHPSTE-----ALVSAMWDFPG--------ID 1817
            ...|.:.|::.:|  |....||   ..:.||.|...:.|     .::.||:..||        :.
 Worm  1190 LQVSTARPDLMVSMPPLPLETSIMGNHSDFYVNSWDTAENSTANDILHAMFSSPGTGPRCAKDVP 1254

Human  1818 NMCLNTSDLQCL----------------NKDSLEK----WNTSGE--------------PITNFG 1848
            |..|:|...:.:                :|||::.    .|..||              ||    
 Worm  1255 NDLLDTMRRELMFRNRYGFGRNKPAPGVDKDSVDNEYQCQNIQGEFDYTEDISNATYNAPI---- 1315

Human  1849 VCSCSENVQECP----KFNYSPPHRRTYSSQVIYNLTGQRVENYLIST-----ANEFVQKRYGGW 1904
            .|.|.:....|.    |:| .....|..::..|::|||:.:..:.:.|     ||.......||:
 Worm  1316 YCGCEDFGWNCTLEDWKWN-ETNWLRLNTTDRIFDLTGRNLTQFRLITRFAQLANTTAPFFLGGF 1379

Human  1905 SFG-------------------LPLTKD-------LRFDITGV-PA----------NRTL----- 1927
            |.|                   |...||       :..:.||: ||          |.||     
 Worm  1380 SLGHVNQRAQSQADIDTSKRGWLETIKDIAQSMRIINLNTTGIEPATPKVLDPFAQNITLNQVVN 1444

Human  1928 -----------AKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQDQEQ 1981
                       .|||::.:.:...|...|.|:|.|||......|....||:..:||.       .
 Worm  1445 DLLQNLDVRENVKVWFNNKIWPGFPIASNILSNALLRQEDYAIDPEDLGILTMNHPM-------N 1502

Human  1982 ATISSLID-----ILVALSI------LMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWV 2035
            .|||..:|     ...||::      |:..|:..|.|..|:|.:...:|..||.:.|:....|||
 Worm  1503 KTISQTLDQNALKFTQALAVFRITILLLVLSMIPAGFTVYLVEDRICEALHLQLVGGLRKVTYWV 1567

Human  2036 TNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAV--SLLLLLF--GYATFSWMYLLAGLFH 2096
            |:::||||.|.:.:...:.|...|::..|.::   ||.  :.|||.|  |.:|..:.|:....|.
 Worm  1568 TSYLYDMVVYTLVIIVIMLIYLCFRVSDFTAD---GATFFAFLLLFFVHGMSTILYAYVFQKAFS 1629

Human  2097 ETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIE 2161
            ...::|:.....:.|.||  :.:|:|: .|......||:|.........:||:.||:..|.    
 Worm  1630 VAALSFVLIAIGSYFVGI--VCALTVI-MLESLMVQDPSLIPAHTVCSIVFLVLPQYNLGI---- 1687

Human  2162 LSQQQSVLDFLKAYGVEYPNETF--EMNKLGAM----FVALVSQGTMFFSLRLLINESLIKKLRL 2220
                 ::...|..|.|......|  :||:...:    ..:|::...|...:..|....:|..:.|
 Worm  1688 -----AIFRGLMIYQVRAIGSNFLQQMNRPDMINQLPLPSLLAFDQMGIHIMCLFIHVIIATICL 1747

Human  2221 FFRK-----FNSSHVRETID----------EDEDVRAERLRVES---GAAEFDLVQLYCLTKTYQ 2267
            .|.:     |.....|...|          :||||..||.||::   .:::...:.:..|.|.| 
 Worm  1748 IFSQMDEFGFVRKRERNLTDAMMLREPSTCDDEDVVKERQRVDAIPMDSSDNHALIVRNLAKAY- 1811

Human  2268 LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN---KTGSLGHV 2329
              :.:::||..||..:..||||||||:|||||||.|.|||..|.|..|:|.::|   .|||...|
 Worm  1812 --NPELLAVKGISFAVEPGECFGLLGLNGAGKTTTFAMLTAKIRPGHGSIEMQNTRINTGSFSDV 1874

Human  2330 DSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCS 2394
            .:...| |||||.|||:..::..|:|.||||:.||....|...:.:||..|||.|:.:..||..|
 Worm  1875 RNFQQL-GYCPQFDALNMKLSTRENLKFYARIRGIVPTQIDSIIDRLLIALHLRPYANTQTSSLS 1938

Human  2395 YGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALC 2459
            .|.:||||.|:||:.:||::.|||||:||||.|::.|||:|....::..:|:|||||||||||||
 Worm  1939 GGNRRKLSVAVALVSQPSLIFLDEPSAGMDPGSQQFLWKVIERLCKSGKAVVLTSHSMEECEALC 2003

Human  2460 TRLAIMVNGKFQCIGSLQHIKSRFGRG--FTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQ--- 2519
            ||:|||..|:.:|:|..||:||::|:|  .|:|:....|...:..:.        ::.|.|.   
 Worm  2004 TRIAIMDRGRIRCLGGKQHLKSKYGKGSMLTMKMGKDENAKEIAGIM--------RSKLGDGSRV 2060

Human  2520 ---HLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAK-DQKSYE---- 2576
               |.|.:..|:......||.:.:::...|...::.:|.::|:||:.||.:.|: |..|.|    
 Worm  2061 EAIHCSTIFIHIEQGTASVARVLEIVNQVKKMYDVDDFTLTQSTLDNVFQSIAESDNLSEEGHHG 2125

Human  2577 TADTSSQGSTIS 2588
            |..:.::.:|.|
 Worm  2126 TLSSINRNNTAS 2137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324 28/78 (36%)
rim_protein 752..2579 CDD:130324 560/2036 (28%)
abt-2NP_490949.3 rim_protein 39..2117 CDD:130324 664/2784 (24%)

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