DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRF2BP1 and Pits

DIOPT Version :9

Sequence 1:	NP_056464.1	Gene:	IRF2BP1 / 26145	HGNCID:	21728	Length:	584	Species:	Homo sapiens
Sequence 2:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	228/750 - (30%)
Similarity:	293/750 - (39%)	Gaps:	298/750 - (39%)

- Green bases have known domain annotations that are detailed below.

Human     7 SRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSHVLPEGRSPGPPA 71
            ::||.|||||||:|||||:.||||||||||||:|||||||.::|||||:||.|          ||
  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLH----------PA 59

Human    72 LKHPATKD-----LAAAAA----------------QG------------PQLPPPQAQPQPSGTG 103
            .|...:.:     .|||||                ||            |..||....|.|||.|
  Fly    60 SKQQRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAG 124

Human   104 GGVSGQDRYDRATSSG----------RLPLP--SPALEYTLGSRLANGLGREEAVAEGARRALLG 156
            ...|..:....|.::.          ::|:|  .|.|:|.:  :|      |:|...|.|...:.
  Fly   125 SLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPV--KL------EDAPGGGVRPVRIS 181

Human   157 SM-PGLMPP-------GLLAAAVSGLGSRGLTLAPGLS------PARPLFGSDFEKEKQQRNADC 207
            .| |..:||       |.....|...||.|.:|.|.||      |:..:   |.:..:||:
  Fly   182 HMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDV---DVDVSQQQQ---- 239

Human   208 LAELNEAMRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATAR-------- 264
                                                   :..|||     |.|.:|.
  Fly   240 ---------------------------------------QSGHGL-----APDGSAGNSLSAGGG 260

Human   265 -----PPGYEFELKLFTEYPCGSGNVYAGVLAVARQMFHDALREP---GKALASSGFKYLEYERR 321
                 |||.:   :...:.|.|.|.                 |.|   |::|.::    :.|...
  Fly   261 VSGGCPPGIK---RSAMDDPSGVGG-----------------RPPLTRGESLPAA----VSYVPE 301

Human   322 HGSGEWRQLGELLTDGVRSFREP--AP---------AEALPQQYP---------EPAPAALCGPP 366
                  |||     .|:|..::|  ||         |..:|...|         .||.......|
  Fly   302 ------RQL-----SGLRDKQQPVRAPSFDASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSP 355

Human   367 PRAPSRNLAPTPRRRKASPEPEGEAAGKMTTEEQQQRHWVAPGGPYSAETPGVPSPIAALKNVAE 431
            |.      .|.|.|...||...|.::|:.::   ..|| |:.....|:|..| .:|..|:  ||.
  Fly   356 PS------GPLPPRSVHSPNSSGSSSGRRSS---GSRH-VSSTTVTSSEVGG-SNPGQAV--VAG 407

Human   432 ALGHSPKDPGGGGGP--------------------VRAGGASPAASS----------TAQPPTQH 466
            .||     .||||||                    ..:||...:|||          .:..|..
  Fly   408 GLG-----GGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNS- 466

Human   467 RLVARNGE--------------AEVSPTAGAEAVSGGG------------SGTGATPGAP----- 500
              ||.:|.              ..|:|..|:....|||            :|:|...|||
  Fly   467 --VAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAA 529

Human   501 ----------------LCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQ-GPAGEVYCPS 548
                            |.||||:||||||||||||||..||||||||||.||.| |...||||||
  Fly   530 SNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPS 594

Human   549 GDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERD 583
            ||:|||..|.:|||||||||.|||..::||||||:
  Fly   595 GDRCPLANSVIPWAFMQGEITTILGEEVKVKKERE 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRF2BP1	NP_056464.1	IRF-2BP1_2	8..59	CDD:402721	40/50 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..127		22/111 (20%)
		pneumo_PspA	<330..>422	CDD:411490	26/111 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..420		21/91 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..495		24/117 (21%)
		vRING-HC_IRF2BP1	501..556	CDD:319629	44/55 (80%)
		Cys-rich	503..550		38/47 (81%)
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155	40/50 (80%)
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	35/44 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158356
Domainoid	1	1.000	97	1.000	Domainoid score	I7250
eggNOG	1	0.900	-	-		E1_KOG3579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3156
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46167
OrthoDB	1	1.010	-	-		D1156771at2759
OrthoFinder	1	1.000	-	-		FOG0001640
OrthoInspector	1	1.000	-	-		otm41805
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10816
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960