DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB20 and CG10321

DIOPT Version :9

Sequence 1:	NP_001157814.1	Gene:	ZBTB20 / 26137	HGNCID:	13503	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	133/640 - (20%)
Similarity:	213/640 - (33%)	Gaps:	205/640 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   162 VLRVSQSEALQIL---TAASILQIKTVIDE--------CTRIVSQNVGDVFPGIQDSGQDTPRGT 215
            :|:....:.|||:   .....||:..::.:        .|...:.|..|:...:..|..|.....
  Fly   270 LLQTPNGQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMGQHVGASLGDADVQL 334

Human   216 PESGTSGQSSDTESGY--LQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPR 278
            .|.|...:..:.|..|  |.|...||.:.|        :.:...::.|    :..|||
  Fly   335 LEDGCEVEDEELEDVYEQLDSKADHSFETI--------VLDDDQQQDF----LKDHHE------- 380

Human   279 DHHM----EDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEM---EDD 336
             ||.    ||      :.:...|...|.....:             |..:..|..::|.   |:|
  Fly   381 -HHQVMINED------LTQSESQDHEYFDDLDQ-------------QQAMDEIEDEEEQMKPEED 425

Human   337 YDYYGQQRVQILERNESEECTEDTDQAE--------GTESEP--KGESFDSGVSSSIGTEPD--- 388
            .|.:..:.:|:    |.:|..:|.|..|        |.|.:|  .|: .|..:..||...||
  Fly   426 QDTFIIEEIQL----EDDEMLDDPDGEEIDQDCEYIGEEQDPHLSGD-VDDDLEYSIMEPPDGET 485

Human   389 --SVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITVSNS 451
              .::|.|     .||:....|..|                      |....:.:::.|:..|.:
  Fly   486 SVDIDQAF-----MDSEQSHHQQHQ----------------------EEMQSISLENAVVEFSQA 523

Human   452 SDKS-VLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQ 515
            :..: .|..|::..|...|.|..                  ...||.|:         ||..|.:
  Fly   524 TTTTEALVGPTMTVSSASPTPKR------------------AKRSNHQI---------PAGVTLE 561

Human   516 PAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAG--------------- 565
            |....|         |.||.     |.|....:..:.||.....:.::||
  Fly   562 PCDHQP---------PAAGS-----TTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEF 612

Human   566 ---HSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTG------EKPHQCSICWRSFSLKDYL 621
               |::..|.|.   |.|.||:..|...:....||..||.      :|..||.||.:||.....|
  Fly   613 IRQHTSPLGSGR---YICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGML 674

Human   622 IKHMVTHTGVRAY-QCSICNKRFTQKSSLNVHMRLHRGEKSYECYI--CKKKFSHKTLLERHVAL 683
            ..||.||....:. .|:|||:.|..|:.|..|.:.|: :::|.|.:  |:|.||....|:.||
  Fly   675 RMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHV-- 736

Human   684 HSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHV 738
                            ....|.||    ...:.|..|.:.:|.:    |.:::||
  Fly   737 ----------------ERKHPEVV----DPLFKCGECGSLYDNV----DSLQLHV 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB20	NP_001157814.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		BTB_POZ_ZBTB20_DPZF	79..195	CDD:349517	7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..235		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..440		21/104 (20%)
		PHA03169	<352..>442	CDD:223003	21/104 (20%)
		Med15	<378..>571	CDD:312941	36/216 (17%)
		zf-C2H2	578..600	CDD:395048	7/21 (33%)
		C2H2 Zn finger	580..600	CDD:275368	6/19 (32%)
		SUF4-like	608..>657	CDD:411020	18/49 (37%)
		C2H2 Zn finger	608..629	CDD:411020	9/20 (45%)
		C2H2 Zn finger	608..628	CDD:275368	8/19 (42%)
		zf-C2H2	634..656	CDD:395048	8/22 (36%)
		C2H2 Zn finger	636..656	CDD:411020	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		zf-H2C2_2	648..673	CDD:404364	8/26 (31%)
		C2H2 Zn finger	664..684	CDD:275368	8/21 (38%)
		C2H2 Zn finger	717..737	CDD:275368	4/19 (21%)
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	28/155 (18%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
		C2H2 Zn finger	690..710	CDD:275368	8/19 (42%)
		C2H2 Zn finger	717..740	CDD:275368	8/40 (20%)
		C2H2 Zn finger	750..767	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100