DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8176 and PSTPIP1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_001308066.1	Gene:	PSTPIP1 / 9051	HGNCID:	9580	Length:	481	Species:	Homo sapiens

Alignment Length:	390	Identity:	92/390 - (23%)
Similarity:	173/390 - (44%)	Gaps:	41/390 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VDFNDYFWGE---KNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAG---T 61
            :.|.|.||..   .:.||:||...:..|....|::.|.||:::..||:..|.:.::|.|||   .
Human    70 LQFKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTE 134

  Fly    62 LNSTFAPVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYAD---ELHKKHKSVKE--EESQTLE 121
            :||..|. :..|:...|.:.:.|:|:...|.|.::.:.::.:   |..||:::|.:  ::|:...
Human   135 INSLRAS-FDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSL 198

  Fly   122 CVQAIQTSTVAVQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEE-------YKALLD 179
            ..:|:::.....||.||...:: |..|:: ..||..|..||.::|.::.::.       |:..:.
Human   199 YKKAMESKKTYEQKCRDADDAE-QAFERI-SANGHQKQVEKSQNKARQCKDSATEAERVYRQSIA 261

  Fly   180 KHNPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSV 244
            :...::.|:|:....||:.||..|...|..::..|..:...|........:::.:.:......|:
Human   262 QLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSI 326

  Fly   245 DKLLEQFVLNKYTGLEKP-EMP-----ELEYVALSSGSRLQQ-----PQVSASASNSNSATSIQA 298
            |..::.|:..|.||.|.| .:|     :.|...|:|...:|.     .:.|.....|...||:
Human   327 DADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSL-- 389

  Fly   299 ALRAGNAATTASGSAVSMDQRGDALA-AISLGSGSAASGSIPFAEDPILGAMGSPRPTSPDMLAG 362
               |.:||:|.:.:.......|...| |:....|:.||   |..|...|....:..|...|:.||
Human   390 ---AASAASTETLTPTPERNEGVYTAIAVQEIQGNPAS---PAQEYRALYDYTAQNPDELDLSAG 448

Fly 363 362
Human 449 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	63/281 (22%)
		Apolipoprotein	52..214	CDD:279749	40/176 (23%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
PSTPIP1	NP_001308066.1	F-BAR_PSTPIP1	81..322	CDD:153355	54/243 (22%)
PSTPIP1	NP_001308066.1	SH3_PSTPIP1	428..480	CDD:212758	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2080
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840