DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and HOF1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_013746.1	Gene:	HOF1 / 855048	SGDID:	S000004635	Length:	669	Species:	Saccharomyces cerevisiae

Alignment Length:	697	Identity:	127/697 - (18%)
Similarity:	231/697 - (33%)	Gaps:	221/697 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVDFNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKA------ 59
            |:..:...||...:||.::|..::..|:.:...:..|.:::|.:|:..::.:..:..|.
Yeast     1 MSYSYEACFWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSELEKDYARRLGAITGKLDKDIGT 65

  Fly    60 ----GTLNSTFAPVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTL 120
                |.||.||                          .:|..|.|...:.|.|...:
Yeast    66 NMDYGKLNETF--------------------------NVVLSVEKARAQSHSKQSEI-------- 96

  Fly   121 ECVQAIQTSTVA-VQKLRDLYASKVQELEKLRKDN-GSHKDAEKLESKLKKLQEEYKAL-LDKHN 182
             ..:.|.|.|.| ...|:..|.:...::|:||.|. ...|..|.|:.||:..|..::.| |:::|
Yeast    97 -LFRQIYTDTKAFAANLQARYTTLSGKIERLRMDKFNKKKGCEVLQKKLQDAQIRFRDLQLNENN 160

  Fly   183 PIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSD-FKRQFVDMSVDK 246
            .|          ..||.    |.:.|::.::.|...|.         :|..| .|:::      |
Yeast   161 MI----------GAKRV----EHNKRELLKWESNSQEY---------KVQLDVLKQEY------K 196

  Fly   247 LLEQFVLNKYTGLEKPEMPELEYVALS-SGSRLQQPQVSASASNSNSATSIQAALRAGNAATTAS 310
            ..::|.::::..| ..|:.|:|...:| ..|:|||                         ..|:|
Yeast   197 ASQKFWIHEWAQL-SCELQEMENARISFLQSKLQQ-------------------------FATSS 235

  Fly   311 GSAVSMDQRGDALAAISLGSGSAASGSIPFAEDPILGAMGSPRPTSPDMLAGAN---ASGIQ--S 370
            .....::|....:....|.|.:||.....|:::...|.: ..:.:..||.:.||   .|.|.  |
Yeast   236 METYILEQTKMDMLTNHLNSFTAADEISTFSKENGTGRL-KHKTSKGDMNSSANWAQMSSISTTS 299

  Fly   371 QPTGGATSTVKSLRSWFLPTAKQQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATT 435
            :.|......::.|.|....|..::..|....:   .....:...|..|...||..:..|.|....
Yeast   300 KKTESYMDNIRKLSSQLKETENKRKLASIDKY---EKPLPSPEVTMATQFRNSTPVIRNETKVVA 361

  Fly   436 TTTTG--------TNNLTTNITKNSPN-------------SEDTSNQDQ---------------- 463
            ..|..        .:|:..::.:..|:             .||:.|.|:
Yeast   362 NPTLSLRSSPVQLQSNVDDSVLRQKPDKPRPIVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPS 426

  Fly   464 -------------TQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLN-------EQ 508
                         .::|..|::|.:.|:.|            |:....|:.:||.|       ..
Yeast   427 ESSSSNPTDFSHIKKRQSMESMTTSVSSMA------------NSIDDSQRFAKSWNSSNRKRKSM 479

  Fly   509 EHLQQTAAATAATTAAATTATTT--------TSRRATSLLNIF---------------------- 543
            .|||..::|::.:.....|..:.        .:||.||...|.
Yeast   480 SHLQVPSSASSRSDDGGRTPNSAHNLNEDDYNTRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIM 544

  Fly   544 --TSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLDRG 588
              :||.....:....|.::.:|...|      ..||.:||....|||
Yeast   545 QDSSNPIEDALYEMERIQSSSKPGTK------TGNIMDERGVVRDRG 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	52/271 (19%)
		Apolipoprotein	52..214	CDD:279749	35/174 (20%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
HOF1	NP_013746.1	FCH	8..92	CDD:214492	19/109 (17%)
		SMC_prok_B	<110..>233	CDD:274008	36/177 (20%)
		SH3	600..663	CDD:214620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2080
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940