DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8176 and GAS7

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_958839.1	Gene:	GAS7 / 8522	HGNCID:	4169	Length:	476	Species:	Homo sapiens

Alignment Length:	285	Identity:	70/285 - (24%)
Similarity:	130/285 - (45%)	Gaps:	44/285 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DYFWGEKNN--------GYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKA---- 59
            ||||.:|.:        |:::|......|....||:|||:||:..|||..:|.::||:..:
Human   202 DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQ 266

  Fly    60 --GTLNSTFAPVWTILRTSAEKLSTLHLQMVQKL-TELVKDVAKYADELHKKHKS----VKEEES 117
              |:|...:|.|...|...||    :||:...|| :|:.|.:..:.:...|..|.    :.:...
Human   267 EEGSLGEAWAQVKKSLADEAE----VHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRK 327

  Fly   118 QTLECVQAIQTSTVAV-QKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKH 181
            |......:::.:..|: ::.||| ..|.|:|| ::..|.:.:|.:|...|..:..::....:|.:
Human   328 QLASRYASVEKARKALTERQRDL-EMKTQQLE-IKLSNKTEEDIKKARRKSTQAGDDLMRCVDLY 390

  Fly   182 NPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDK 246
            |..::::...|..|....:.:|...:..:::.|..|.: |::..||       |.:..|: .||:
Human   391 NQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQ-LRHETDM-------FNQSTVE-PVDQ 446

  Fly   247 LL---------EQFVLNKYTGLEKP 262
            ||         |.:|....||..:|
Human   447 LLRKVDPAKDRELWVREHKTGNIRP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	66/281 (23%)
		Apolipoprotein	52..214	CDD:279749	35/173 (20%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
GAS7	NP_958839.1	SH3_GAS7	5..57	CDD:212763
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..171
		WW_FCH_linker	109..201	CDD:374680
		F-BAR_GAS7	214..446	CDD:153333	57/246 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2080
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840