DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and SGIP1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	XP_016857994.1	Gene:	SGIP1 / 84251	HGNCID:	25412	Length:	850	Species:	Homo sapiens

Alignment Length:	859	Identity:	226/859 - (26%)
Similarity:	340/859 - (39%)	Gaps:	303/859 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 ALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPNAGALTNSASITAPGA------ASGTGTGY-- 674
            |..:...:...||.|:....|...:       |:.....:.|.....|.      ::|...|:
Human    12 AFGIRKKEKDTDSTGSPDRDGIQPS-------PHEPPYNSKAECAREGGKKVSKKSNGAPNGFYA 69

  Fly   675 ----------EVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQERRIHVSIKP----- 724
                      |:||||:||:|.     |.|..|...|||.|::: :.::..::.::.|||
Human    70 EIDWERYNSPELDEEGYSIRPE-----EPGSTKGKHFYSSSESE-EEEESHKKFNIKIKPLQSKD 128

  Fly   725 -LKNGQAPMSASVDELRATVENISLSPT----------GVFSHHSQQLQAARGAPASRQQSPEIS 778
             |||     :|:||||:|::.||:|||:          |....:....:.||  |.....:||:.
Human   129 ILKN-----AATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVAR--PRRSTPTPELI 186

  Fly   779 NASTP--TASVHP-YAP------------------------------LQSPTLS----------- 799
            :...|  |.::.| :.|                              ::||.|:
Human   187 SKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLTRPFPTGTPPPL 251

  Fly   800 ---------------------NNNNANNTTNSRYADLGDIFSELG-------------------- 823
                                 |:.:|......:...:.|:.|..|
Human   252 PPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGPVLSPKSVAVNAEEKWVHFS 316

  Fly   824 ------------------------DMSMSAPSSATLGKP----------PGRQIPTP-------- 846
                                    |....:|:...||.|          |.|.:.:|
Human   317 DTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPGPTGPPGPPGPPRNVLSPLNLEEVQK 381

  Fly   847 --------------TSASTG----GSIAIPRPPSRRSDMIAIGPAATGTAPGRG----------- 882
                          |.:|..    |..|.|.||...:....:.....|:.||.|
Human   382 KVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPPPTYRTVVSSPGPGSGPGPGTTSGASSPARP 446

  Fly   883 --------------------------------------------RMSPAPVTAMNRAESIGSLEF 903
                                                        ..||.|:..:.||||..|:..
Human   447 ATPLVPCRSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISS 511

  Fly   904 RTAIGGV-----------------------------------------------GSSRGPSPLTI 921
            ..::...                                               ||||||||||:
Human   512 TNSLSAATTPTVVSEDDVFYDKLPSFERRCETPAENEQPSLVWFDRGKFYLTFEGSSRGPSPLTM 576

  Fly   922 GISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAKLGFRIKHVQ 986
            |..||:|:|.||.|.::|||:|:|.|:|.||::|:|:|||||||....||||:||.|.||:.:..
Human   577 GAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFS 641

  Fly   987 NLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILKYQVRTKPGA 1051
            .||:::||.:|:..|..|:.:.:.....||..|...|::.:|..|.|:|:|||:|||||..: |.
Human   642 RLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQ-GI 705

  Fly  1052 SSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASPLLNVTLSVPVNGSVRNVQS-KPHSAWLGE 1115
            .|.|..|...|:||.|.|.|::|||||..||.:|..|.||...||::|.|..:|: .|.:.|..|
Human   706 QSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAE 770

  Fly  1116 SNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPALLATQFNCEGTTLSGIEFELQGSGYRLS 1180
            ..|::|...||||.|::||||:|.||.:|::|||.|:.|..||..||:||||.:.||.|:|||.|
Human   771 QQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFS 835

  Fly  1181 LVKRRFVSGKYVCE 1194
            |:|:||.:|||:.:
Human   836 LIKKRFAAGKYLAD 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332
		Apolipoprotein	52..214	CDD:279749
		AP_Syp1_like_MHD	928..1194	CDD:271171	126/266 (47%)
SGIP1	XP_016857994.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145129
Domainoid	1	1.000	273	1.000	Domainoid score	I1787
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286007at33208
OrthoFinder	1	1.000	-	-		FOG0001508
OrthoInspector	1	1.000	-	-		otm42208
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810