DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and Fcho1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_082991.3	Gene:	Fcho1 / 74015	MGIID:	1921265	Length:	873	Species:	Mus musculus

Alignment Length:	1250	Identity:	335/1250 - (26%)
Similarity:	495/1250 - (39%)	Gaps:	445/1250 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKA--GTLNSTFA 67
            |.::|||:||:|::||||.:|.|.:|:|||::|:||::||||..||.|:||:..|  ||...|||
Mouse     4 FGEHFWGDKNHGFEVLYHCVKQGPVATKELADFIRERANIEETYSKAMAKLSKLASNGTPMGTFA 68

  Fly    68 PVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVA 132
            |:|.:.|.|::||:..||::.:||.:|:|||.:|.:|..|.||..|||...|::.||.:......
Mouse    69 PLWEVFRVSSDKLALCHLELTRKLHDLLKDVLRYGEEQLKTHKKCKEEVLGTVDAVQMLSGVGQL 133

  Fly   133 VQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCK 197
            :.|.|:.|.|:..:||:||::|.|.|:.:|.|:|.||..:..:..:||:|..:.:||.:|..:..
Mouse   134 LPKSRENYLSRCMDLERLRRENTSQKEMDKAETKSKKAADSLRRSVDKYNSARADFEIKMLDSAL 198

  Fly   198 RFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKP 262
            |||.:||.||:.||..|.:|...:::.|..:||||.:||:...:::||.||.:|..:|.||.|||
Mouse   199 RFQAMEEAHLQHMKALLGSYAHSVEDTHVQIGQVHEEFKQNVENVTVDMLLRKFAESKGTGREKP 263

  Fly   263 EMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALRAGNAATTASGSAVSMDQRGDALAAIS 327
              ..|::.|.||                       |||:
Mouse   264 --GPLDFDAYSS-----------------------AALQ-------------------------- 277

  Fly   328 LGSGSAASGSIPFAEDPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTAK 392
                                                              ..:|.||
Mouse   278 --------------------------------------------------EAMKRLR-------- 284

  Fly   393 QQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSED 457
                 ||..|.:.|
Mouse   285 -----GAKAFRLPG--------------------------------------------------- 293

  Fly   458 TSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLNEQEHLQQTAAATAATT 522

Mouse   294 ----------------------------------------------------------------- 293

  Fly   523 AAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLDR 587
                                           .|||:
Mouse   294 -------------------------------LSRRE----------------------------- 298

  Fly   588 GNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPNA 652
                                                .:.|||.
Mouse   299 ------------------------------------PRASVDF---------------------- 305

  Fly   653 GALTNSASITAPGAASGTGTGYEVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQERR 717
                         ..|.:|...|||:|||:::|  :|:...|.:...  :|.||:|.| |::.|:
Mouse   306 -------------LESDSGVPPEVDDEGFTVRP--DISQNNGAEPPR--FSSSDSDFD-DEEPRK 352

  Fly   718 IHVSIKPLKNGQAPMS--ASVDELRATVENISL--SPTGVFSHHSQQLQAARGAPASRQQSPEI- 777
            .:|.|||........|  |:..:||||..::.|  .|.|....||.  :...|.|...:.:|..
Mouse   353 FYVHIKPAPTRAVACSSEAAAAQLRATAGSLILPPGPGGTMKRHSS--RDTSGKPQRPRSAPRTG 415

  Fly   778 SNASTPTASVHPYA-PLQSPTLSNNNNANNTTNSRYADLGDIFS----------ELGDMSMSAPS 831
            |.|..|.||..|.: .|..|.|.:..:.::.|.|  :.||...|          .:.|..:.:||
Mouse   416 SCAEKPLASEEPLSKSLFGPPLESAFDHDDFTGS--SSLGFTSSPSPFSSSSPENVEDSGLDSPS 478

  Fly   832 SATLGKPPGRQIP---TPTSAST------------------------GGSIAI-PRPPSRRSDMI 868
            .|..|..|...:|   ||.|..|                        ||:.:: |..|:|.
Mouse   479 HAAPGPSPESWVPRPGTPQSPPTCRAQHPEPRGLMPRAPSPGPWGPEGGADSLTPADPTRE---- 539

  Fly   869 AIGPAATGTAPGRGRMSPAPVTAMN----RAES---IGSL---------EFRTAIGGVGSSRGPS 917
              |.|||...| |.|....|:|..|    |:.|   :||.         .|.|.:|. |.|||||
Mouse   540 --GLAATLRRP-RSRKVSCPLTRSNGDLCRSLSPSPLGSSAPTIPPDRPSFSTQMGH-GISRGPS 600

  Fly   918 PLTIGISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAKLGFRI 982
            |:.:|..|.:|:|.||.|.:||||||...| |..:|:|::.::|||||..:.:..|.|..|.||:
Mouse   601 PVVLGSQDALPVATAFTEYVHAYFRGHSPS-CLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRL 664

  Fly   983 KHVQNLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILKYQVRT 1047
            .:...:|:..||..|:..|..||...:.....||.|||..|:.|||.||||||:|:.:|:||. :
Mouse   665 VNTAPVEHFQPNADLIFSDPSQSDPETKDFWLNMAALTEALQHQAEQNPTASYYNLVLLRYQF-S 728

  Fly  1048 KPGASSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASPLLNVTLSVPVNGSVRNVQSKPHSAW 1112
            :||..|.|.|:.::|:|..:.|.:.|:|.|...|.|.::||.||.:.:||...|.:|:.:|.:.|
Mouse   729 RPGPESVPLQMSAHWQCGPTLTRVSVEYSYRAGATAVSTPLTNVQILLPVGEPVTSVRLQPAATW 793

  Fly  1113 LGESNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPALLATQFNCEGTTLSGIEFELQGSGY 1177
            ..|..|..|...|:   .:.||.|.|.|..:...|||||:.:|.||..||.||||::.||.|.||
Mouse   794 NTEEKRFTWKLPDV---CEAGGSGHLSASWQPQSGPSTPSPVAAQFTSEGATLSGLDLELLGGGY 855

  Fly  1178 RLSLVKRRFVSGKYV 1192
            |:|||||||.:|.|:
Mouse   856 RMSLVKRRFATGMYL 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	109/259 (42%)
		Apolipoprotein	52..214	CDD:279749	65/163 (40%)
		AP_Syp1_like_MHD	928..1194	CDD:271171	112/264 (42%)
Fcho1	NP_082991.3	Mediates membrane-binding. /evidence=ECO:0000250	1..275		115/295 (39%)
		F-BAR_FCHO1	10..270	CDD:153358	109/261 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..172		8/18 (44%)
		Mediates interaction with the adaptor protein complex AP-2. /evidence=ECO:0000250	267..439		64/537 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..347		19/84 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..600		59/230 (26%)
		Mediates interaction with AGFG1, CALM, DAB2, EPS15, EPS15R, ITSN1 and clathrin. /evidence=ECO:0000250	593..873		121/283 (43%)
		AP_MHD_Cterm	611..872	CDD:385861	112/264 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	813..833		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835233
Domainoid	1	1.000	230	1.000	Domainoid score	I2441
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I990
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286007at33208
OrthoFinder	1	1.000	-	-		FOG0001508
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104540
Panther	1	1.100	-	-	LDO	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860