DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8176 and pstpip1a

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_001038681.1	Gene:	pstpip1a / 571331	ZFINID:	ZDB-GENE-050419-251	Length:	418	Species:	Danio rerio

Alignment Length:	354	Identity:	82/354 - (23%)
Similarity:	153/354 - (43%)	Gaps:	67/354 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VDFNDYFWGEK---NNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKA----- 59
            :.|.|||||.|   |:||::|...:..|..|.|::.|.|:.::..||:..|.:..:|.|.
Zfish     4 LQFKDYFWGPKFTSNSGYEILIQRLCDGRRACKDMEELLKMRAMAEERYGKELITIARKTGGQTE 68

  Fly    60 -GTLNSTFAPVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECV 123
             |||.::|..    |:...|.:..||:|    |:.::::.||..:...::.|..:::....:|.|
Zfish    69 IGTLKASFDQ----LKAQMENIGNLHIQ----LSGMLREEAKRMEHFRERQKEQRKKFEGVMEKV 125

  Fly   124 QAIQTSTV-AVQKLRDLYASKVQE-------LEKLRKDNG-SHKDAEKLESKLKK-------LQE 172
            |.|:.|.. ...:.:..|..:.:|       .|||...:. :.|.:||.::|.|:       .::
Zfish   126 QKIKVSLYKKTMESKRTYEQRCREADEAELTAEKLNSTSTVTPKQSEKTQNKAKQCRDAATDAEK 190

  Fly   173 EYKALLDKHNPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSD--- 234
            :|.:.:::.:.|:.|:|.....||:.||:.|:..:..::..:..:.     ||..:..|..|
Zfish   191 QYISNIEQLDKIRQEWETTHELTCEVFQQQEDDRINILRNAIWVHC-----NHFSMQCVKEDECY 250

  Fly   235 ----FKRQFVDMSVDKLLEQFVLNKYTGLEKPEMP-------ELEYVALSSG------------S 276
                ...:..|::.|  :..|:..|..| ..|.:|       |.|..|.|:|            |
Zfish   251 EEVRTTLEMCDITED--INSFIKTKSIG-NTPSVPIVFENYYEKEQQADSNGIIRFGGGVMKRFS 312

  Fly   277 RLQQPQVSASASNSNSATSIQAALRAGNA 305
            .|.|...:..:.|:|......|...|.|:
Zfish   313 NLLQGNCAIGSRNNNECIVPSAPPSADNS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	65/296 (22%)
		Apolipoprotein	52..214	CDD:279749	39/183 (21%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
pstpip1a	NP_001038681.1	F-BAR_PSTPIP1	15..258	CDD:153355	55/255 (22%)
pstpip1a	NP_001038681.1	SH3_PSTPIP1	365..417	CDD:212758
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2080
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840