DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8176 and sgip1a

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	XP_021327453.1	Gene:	sgip1a / 566542	ZFINID:	ZDB-GENE-131121-25	Length:	976	Species:	Danio rerio

Alignment Length:	995	Identity:	246/995 - (24%)
Similarity:	357/995 - (35%)	Gaps:	400/995 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 QEERLTSLDRGNNTLLDYDDHGRSMKTQNSSGSSAGG--------GL-----AALSVTSAQGSVD 629
            ||||:.   :||  :..:.|....::....| ..||.        ||     .|..:...:...|
Zfish     3 QEERIV---KGN--IKGFSDGSERLRLLALS-QMAGALIISLLFTGLKKRTRKAFGIRKKEKDTD 61

  Fly   630 SAGASSMGGSGGAAVASGSLPNAGALTNSASITAPGAASG-----TGTGYEVDEEGFSIQPAKEI 689
            |.|:....|.....:.|......|         ||....|     .....|:||||:||:|.:
Zfish    62 STGSPDRDGGEPQEIESPQKKTNG---------APNGFYGEIDWDRYNSPELDEEGYSIRPEE-- 115

  Fly   690 AWEEG---QDKSGSFYSDSDTDSDNDKQERRIHVSIKPLKNGQAPMSASVDELRATVENISLSPT 751
              |||   ::|: .|:|.|:::.:.| ..::..:.||||....:..:.|||||:|::.||:|||:
Zfish   116 --EEGAVSKEKT-HFFSSSESEEEED-HRKKFKIKIKPLPADASFAAPSVDELKASIGNIALSPS 176

  Fly   752 ----------GVFSHH-SQQLQAARGA---------------------PASRQQS---------- 774
                      |:...: ..::...|.|                     |||.::|
Zfish   177 PLRNSPRRSPGLAKRNPCDEIARPRRAVPAPAPVSAPSPTPAPVVLPEPASNKKSPVPEDTTALF 241

  Fly   775 --------------------PEISNAST-------------PTASVHPY---------APLQSPT 797
                                ||:..|..             ||.::.|.         .|::|||
Zfish   242 GPPLETAFDEQKTSEEVIEEPEVWGAPLPEQHLDSSLARPFPTGTLPPLPPKNVPTSPPPIESPT 306

  Fly   798 L------SNNNNANNTTNSRYADLGDIFSELGDMSMS---------------------------- 828
            .      ...|:...:.....|||.:||.......:|
Zfish   307 TEPADVQKEGNSRQTSQRPSIADLDNIFGPENSPKLSQDIEDTWVCFNDESPERHSPPLEGEPAL 371

  Fly   829 -----------------------------------------------------------APSSAT 834
                                                                       .||..|
Zfish   372 QSSPPPPAEPAPPLPKSPPPLDEPTPPLPKSPPLPSEPAPSPPACEPLRESPPPVLKDKTPSPPT 436

  Fly   835 LGKPPGRQIPTP-----------------------------------TSASTGGSIAI------- 857
            :..||..:.|.|                                   |||.|..|..:
Zfish   437 VPPPPIEEAPLPPTPDDVFHTTTDFSPCAPLTETQSNTTNSPPNIVETSARTIPSPLVLNQEEVK 501

  Fly   858 -------------------------------PRPPSRRSDMIAIGPAATGTA------------- 878
                                           |.||:.|:.:.:.||....:|
Zfish   502 SPDETPSKEDPSESSTSPKETGQGARSTPPPPPPPTYRAVVSSPGPVPPASASGNESGSSSPARP 566

  Fly   879 ------------------PGRGRM---------------------SPAPVTAMNRAESIGSLEFR 904
                              |.|.::                     ||.|:..:.||||..|:...
Zfish   567 STPLATSSSPPPPPPPRPPSRPKLPPGKPSIGDVNRPFSPPVHSSSPPPLAPLARAESTSSISST 631

  Fly   905 TAIGGV------------------------------------------------------GSSRG 915
            .::...                                                      |.|||
Zfish   632 NSLSAATTPTVGKELSVSVSEDDAFVDKLPSFERRADIPAETDQPSLVWFDRGKFYLTFEGCSRG 696

  Fly   916 PSPLTIGISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAKLGF 980
            |||||:|..||:|:|.||.|.:.|||:|:|.::|.||::|:|:|||||||....||||:||.|.|
Zfish   697 PSPLTMGAQDTLPVAAAFTETVSAYFKGADPNKCVVKITGEMVLSFPAGITRHFANNPSPAVLTF 761

  Fly   981 RIKHVQNLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILKYQV 1045
            .|.:...||:::||.:|:..|..|.:..|.....||..|...|::.||..|.|:|:|||:|||||
Zfish   762 SITNYSRLEHVLPNPQLLCCDSTQPNPNSKEFWVNMPNLMTHLKKVAEQKPQATYYNVDMLKYQV 826

  Fly  1046 RTKPGASSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASPLLNVTLSVPVNGSVRNVQS-KPH 1109
            ..| |..|.|..|...|:||.:.|.|::|||||..||.:...|.||...:||:|.|..:|: .|.
Zfish   827 LPK-GPQSTPLNLAVSWRCEPTSTDLRIDYKYNGGAMTTPVALNNVQFLIPVDGGVSKLQAVLPP 890

  Fly  1110 SAWLGESNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPALLATQFNCEGTTLSGIEFELQG 1174
            .||..|..|::|...||||.|::||||:|.||.:|.:|||.||.:|.||..||:||||.:.||.|
Zfish   891 GAWNSEQQRILWKIPDISQKSENGGVGSLLARFQLTEGPSKPAPVAVQFTSEGSTLSGCDIELVG 955

  Fly  1175 SGYRLSLVKRRFVSGKYVCE 1194
            .|||.||:|:||.:|||:.:
Zfish   956 LGYRFSLIKKRFAAGKYMAD 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332
		Apolipoprotein	52..214	CDD:279749
		AP_Syp1_like_MHD	928..1194	CDD:271171	128/266 (48%)
sgip1a	XP_021327453.1	DNA_pol3_gamma3	<151..325	CDD:331207	29/173 (17%)
sgip1a	XP_021327453.1	AP_MHD_Cterm	709..975	CDD:324770	128/266 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578444
Domainoid	1	1.000	280	1.000	Domainoid score	I1641
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286007at33208
OrthoFinder	1	1.000	-	-		FOG0001508
OrthoInspector	1	1.000	-	-		otm25251
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850