Protein Alignment CG8176 and Fcho2

DIOPT Version :10

• Sequence 1: NP_001097723.1
• Gene: CG8176 / 261329
• FlyBaseID: FBgn0037702
• Length: 1220
• Species: Drosophila melanogaster
• Sequence 2: XP_063137759.1
• Gene: Fcho2 / 309129
• RGDID: 1565396
• Length: 875
• Species: Rattus norvegicus
• Alignment Length: 1232
• Identity: 352/1232 - (28%)
• Similarity: 512/1232 - (41%)
• Gaps: 451/1232 - (36%)

  Fly     5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAGTLN--STFA 67
            |.:.||||||||:||||||||.|.|::|||::|:||::.|||..|:.|:|||..|...:  .|||
  Rat    52 FVENFWGEKNNGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFA 116

  Fly    68 PVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVA 132
            |||.:.:||.|||:..||.:|:||.||:|:|.||.:|..|.||..|||.:.|||.|||||..|.|
  Rat   117 PVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQAIQNITQA 181

  Fly   133 VQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCK 197
            :||.::.|.:|..|.|:|:|:..:.::.||...|.||..:.||..::|:...|.:||::||:|.:
  Rat   182 LQKSKENYNAKCVEQERLKKEGATPREIEKAAVKSKKATDTYKLYVEKYALTKADFEQKMTETAQ 246

  Fly   198 RFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKP 262
            :||:|||.||..:||.:.:....::..|..:||||.:|.....:.:::.|:::|..:|.||.|:|
  Rat   247 KFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTIESLIQKFAESKGTGKERP 311

  Fly   263 EMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALRAGNAATTASGSAVSMDQRGDALAAIS 327
                                                                             
  Rat   312 ----------------------------------------------------------------- 311

  Fly   328 LGSGSAASGSIPFAE-DPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTA 391
                    |.|.|.| ||                                .|.|:.::
  Rat   312 --------GLIEFEECDP--------------------------------ASAVEGIK------- 329

  Fly   392 KQQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSE 456
                                                                             
  Rat   330 ----------------------------------------------------------------- 329

  Fly   457 DTSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLNEQEHLQQTAAATAAT 521
                                          |.|::..|
  Rat   330 ------------------------------PRKRKTFA--------------------------- 337

  Fly   522 TAAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLD 586
                                       :.||:            ||:||.|:.|
  Rat   338 ---------------------------LPGII------------KKEKDAESVE----------- 352

  Fly   587 RGNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPN 651
                                                                          .|:
  Rat   353 --------------------------------------------------------------CPD 355

  Fly   652 AGALTNSASITAPGAASGTGTGYEVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQER 716
            |.      |:..|          :||||||||:|..    .:...|...|||.||:||: |::.:
  Rat   356 AD------SLNIP----------DVDEEGFSIKPEA----NQNDTKENHFYSSSDSDSE-DEEPK 399

  Fly   717 RIHVSIKPL-KNGQAPMSASVDELRATVENISLSPTGVFSHHSQQLQAARGAPASRQQSPEISNA 780
            |..:.|||: .|......||:|||:.::.||:|||  ..|.|| .:|..|.  :|.::..:...:
  Rat   400 RYRIEIKPVHPNNVHHTMASLDELKVSIGNITLSP--AVSRHS-PVQMNRN--SSNEELTKSKPS 459

  Fly   781 STPTA----SVHPYAPL-------QSPTLSNNNNANNTTNSRYADLGDIFSELGDMSMSAPSSAT 834
            |.||.    .:..:.||       .|..|:::::|..||.   ..||.|.
  Rat   460 SLPTEKGTNDLLAWDPLFGSSLESSSAPLTSSSSARPTTP---LSLGTIV--------------- 506

  Fly   835 LGKPPGRQIPTP--TSASTGGSIAIPRPPSRRSDMIAIGPAATGTAPGRGRMSPAPVTAMNRAES 897
               ||.|....|  ||....|...||||         ..|..|...      ||.|...:.||||
  Rat   507 ---PPPRPASRPKLTSGKLSGINEIPRP---------FSPPITSNT------SPPPTAPLARAES 553

  Fly   898 IGSLEFRTAIGGV-------------------------GSSRGPSPLTIGISDTIPLAVAFHEII 937
            ..|:....::...                         |.||||||:::|..||:|:|:|..|.:
  Rat   554 SSSISSSASLSAANTPTVEDDNLIGTLSEIEKHCETTPGVSRGPSPVSLGNQDTLPVAIALTESV 618

  Fly   938 HAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAKLGFRIKHVQNLENLVPNGKLVQIDR 1002
            :|||:|:|.::|.||::||:.:|||:||..:..:||:||.|.||:|::..||.::||.:||..|.
  Rat   619 NAYFKGADPTKCIVKITGDVTISFPSGIIKVFTSNPSPAVLCFRVKNISRLEQILPNSQLVFSDP 683

  Fly  1003 QQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILKYQVRTKPGASSCPFQLVSYWKCESS 1067
            .|..|.:.....||.|:|..|::.:|.||.|||:|||:|||||.:. |..|.|..|.:||||.:|
  Rat   684 SQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSN-GIQSTPLNLATYWKCSAS 747

  Fly  1068 YTALKVDYKYNNHAMASASPLLNVTLSVPVNGSVRNVQSKPHSAWLGESNRLVWNFTDISQNSQD 1132
            .|.|:||||||..||.:.|.|.|:.:.|||:|.|.|:||.|.:.|..|..:..|..:.||:.|..
  Rat   748 TTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSGISEKSDS 812

  Fly  1133 GGVGTLRARLELNDGPSTPALLATQFNCEGTTLSGIEFELQGSGYRLSLVKRRFVSGKYVCE 1194
            ||.|:|||:.:|::|||.||.||.||..||.||||::.||.|:||||||||:||.:|:|:.:
  Rat   813 GGSGSLRAKFDLSEGPSKPATLAVQFLSEGNTLSGVDIELVGTGYRLSLVKKRFATGRYLAD 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	114/259 (44%)
		PHA03307	731..>921	CDD:223039	57/227 (25%)
		AP_Syp1_like_MHD	928..1194	CDD:271171	129/265 (49%)
Fcho2	XP_063137759.1	None