DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and Pstpip1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_001100294.2	Gene:	Pstpip1 / 300732	RGDID:	1307557	Length:	416	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	88/398 - (22%)
Similarity:	160/398 - (40%)	Gaps:	81/398 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VDFNDYFWGE---KNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAG---T 61
            :.|.|.||..   .:.||:||...:..|....|::.|.||:::..||:..|.:.::|.|||   .
  Rat     5 LQFRDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDVEELLRQRAQAEERYGKELVQIARKAGGQTE 69

  Fly    62 LNSTFAPVWTILRTS-------AEKLSTLHLQMVQKLTELVKDVAKYAD---ELHKKHKSVKE-- 114
            :||        ||||       .|.:.:.|:|:...|.|.::.:.::.:   |..||:::|.:
  Rat    70 MNS--------LRTSFDSLKQQTENVGSAHIQLALALREELRSLEEFRERQKEQRKKYEAVMDRV 126

  Fly   115 EESQTLECVQAIQTSTVAVQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEE------ 173
            ::|:.....:.:::.....||.||  |...::..:....:|..|..||.::|.|:.:|.
  Rat   127 QKSKLSLYKKTMESKKSYDQKCRD--ADDAEQAFERVSASGHQKQIEKSQTKAKQCKESATEADR 189

  Fly   174 -YKALLDKHNPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKR 237
             |:..:::....:.|:|:....||:.||..|...|..::..|..:...|........:::.:.:.
  Rat   190 VYRQNIEQLEKARTEWEQEHRTTCEAFQLQEFDRLTILRNALWVHCNQLSMQCVKDDELYEEVRL 254

  Fly   238 QFVDMSVDKLLEQFVLNKYTGLEKP-----------EMPEL--------------EYVALSSGSR 277
            ......|:..:..|:.:|.||.|.|           |:..|              .:..|..||.
  Rat   255 TLEGCDVEGDINGFIQSKSTGREPPAPVPYQNYYDREVTPLTGSPIVQTSCGVIKRFSGLLHGSP 319

  Fly   278 LQQPQVSASASNSNSA----------TSIQAALRAGNAATTASG-------SAVSMDQ----RGD 321
            ...|..:.:||....|          .||:.....||..:.|..       :|.:.|:    .||
  Rat   320 KTTPSQAPAASTETLAPTSEQKELVYASIEVQATQGNLNSAAQDYRALYDYTAQNSDELDISAGD 384

  Fly   322 ALAAISLG 329
            .||.|..|
  Rat   385 ILAVILEG 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	64/307 (21%)
		Apolipoprotein	52..214	CDD:279749	41/183 (22%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
Pstpip1	NP_001100294.2	BAR	16..257	CDD:299863	55/250 (22%)
Pstpip1	NP_001100294.2	SH3_PSTPIP1	363..415	CDD:212758	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810