DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and rga8

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_592988.2	Gene:	rga8 / 2542617	PomBaseID:	SPAC13A11.01c	Length:	777	Species:	Schizosaccharomyces pombe

Alignment Length:	851	Identity:	154/851 - (18%)
Similarity:	271/851 - (31%)	Gaps:	286/851 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVDFNDYFWG-EKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHK------ 58
            |...|::.||. :...|...|:..:..|:..::::...|:......|:..:.:.::..:
pombe     1 MISSFSNGFWSKDYATGVKKLFDCLDNGVEENEQVKNLLKLYKEANEEFGEKLQEITKECLKGKK 65

  Fly    59 ------AGTLNSTFAPVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEES 117
                  ..|.|..|..    ||:........|:::.:.|..|:  :|.::        .:..:.|
pombe    66 PENTEDGATSNKAFEG----LRSEIANQGKQHIRIAKDLETLI--IAPFS--------KMSIDHS 116

  Fly   118 QTLECVQAIQTSTV--------AVQKLRDLYASKVQELEKLRKDN--GSHKDAEKLESKLKKLQE 172
            |.|:..|.:.|:.:        .::|.:..|.:|.:.||...:::  .:...:|.:.........
pombe   117 QKLQTSQQVLTNQIKSYEKKYYTLKKTKSAYYNKCRNLEDYEEESKESNETTSEAITDLTTVSSP 181

  Fly   173 EYKALLDKHNPIKN----EFERRMTQTCKRFQEIEEVHLRQMKE---------FLSTY------- 217
            :.::||:..:.:..    ||         |.:|::||..:.::|         .|.||
pombe   182 QQQSLLENDDDLIQLGFMEF---------RPEELKEVLAQVLQEIPLQDYRVPILGTYPNTCSGN 237

  Fly   218 --LEMLQNN-------------HDMVGQ------------VHS-DFKRQFVDM--------SVDK 246
              :..||.|             .|::.|            |:| :|..|:.|.        |||.
pombe   238 IIVSWLQENLPVPTLVAAEAFGQDLIAQGFLRHMGVGGSFVNSTNFHYQWKDKAFQFAGLNSVDS 302

  Fly   247 LLEQF--------VLNKYTGLEKPEMPELEYVALSSGSRLQQPQVSASASNSNS----------- 292
            |:|..        .|:.|....|      .|.:.:...||::..:.|:...|.|
pombe   303 LVENAKALPLVGEYLSDYISHRK------LYSSETQSQRLKREVLDANKIYSESVVDLDKCRTLV 361

  Fly   293 ----ATSIQAALRAG------------NAATTASGSAVSMDQRGDALAA----------ISLGSG 331
                |..:|...:..            :.:|..|....||....|.:..          |.....
pombe   362 EETIADHLQFLQKCETDRVLYYKDFFMDLSTIISNFLPSMKLLADQIVVYQEIIQPESDIRYILE 426

  Fly   332 SAASGSIPF-------------AEDPILGA----------------------------------- 348
            |||:|  ||             .:|.|.|.
pombe   427 SAATG--PFLPRVEIYEDYYNDIKDQIFGVDVEFLSHRDKKRVPIIVSTILSYLDLLYPTLASDE 489

  Fly   349 -------MGSPRPTSPDMLAGANASG-----IQSQPTGGATSTVKSLRSWFLPTAKQQPSAGAGN 401
                   :.||..:...:....|.|.     :.||.|......|..|....||.:....||
pombe   490 VRQNIWLVNSPLSSVHQLREALNHSSSVTKEVLSQYTPSVVIGVLKLYFLELPDSIVPSSA---- 550

  Fly   402 FGMAGSGSTNNTTTT----TTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSED-TSNQ 461
            |.:..|...|::..|    ....|..:.|...|....:...|..|.|.|    .:||.|. |.|.
pombe   551 FELIRSIYMNHSNDTPYRLRLLQNLLSQLRRVNLATLSAIITHLNRLIT----LTPNKETFTINL 611

  Fly   462 DQTQQQPAEALT-----PTASATAIAAASAPGK-------------KQLNATTSEQQLSKSLNEQ 508
                   |.:|:     |......|.....|.|             ::|....|.:::|..:
pombe   612 -------ANSLSLCISRPATWNLGIQHDKHPTKFMEDLLTYGPSIFEELRKLNSSKRVSDRV--- 666

  Fly   509 EHLQQTAAATAATTAAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNE- 572
              |.|::|...:|..:.|...:.:|.|         |::.|..   .|....:.:.::...::|
pombe   667 --LYQSSATPRSTDVSPTRPDSISSVR---------SHTAVES---PRSSFEELQPSEIPAESEF 717

  Fly   573 AAENIQEERLTSLDRGNNTLLDYDDHGRSMKT-QNSSGSSAGGGLAALSVTSAQGSVDSAGA--- 633
            ..||:.    |||.|.:..|       .:.|| :|.|.|||....||:.:......|:.|.|
pombe   718 TLENVP----TSLIRSSYAL-------NTRKTRRNFSHSSASNESAAIFIDQDAKIVNEAVASRD 771

  Fly   634 SSMGGS 639
            ||:.||
pombe   772 SSLSGS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	55/344 (16%)
		Apolipoprotein	52..214	CDD:279749	29/196 (15%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
rga8	NP_592988.2	FCH	7..96	CDD:214492	13/92 (14%)
		DEP_fRgd2	205..287	CDD:239883	15/81 (19%)
		RhoGAP_fRGD2	452..654	CDD:239864	36/216 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010