DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and imp2

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_596391.1	Gene:	imp2 / 2540112	PomBaseID:	SPBC11C11.02	Length:	670	Species:	Schizosaccharomyces pombe

Alignment Length:	679	Identity:	143/679 - (21%)
Similarity:	254/679 - (37%)	Gaps:	164/679 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAGTLNSTFAPV 69
            |::||||..:.||..|..........::||..|..|::||||..:|.|:||:      .:||:.:
pombe    18 FSNYFWGANDEGYHALLSRFSDVKHINEELRSFYHERANIEEDYAKRMAKLS------RTTFSSL 76

  Fly    70 WT--------ILRTSAEKLSTLHLQMVQKLTELVKDV-AKYADELHKKHKSV--------KEEES 117
            .|        :::...:.::..|||:.|.|.:.|::. .:||..|..|.|.:        |::.|
pombe    77 ETGCLKESVQVMKAEVDNMAKSHLQISQLLQDDVENAFTRYAASLKDKKKMIVSGIEKVHKDKLS 141

  Fly   118 QTLECVQAIQTSTVAVQKLRDLYASKVQEL--EKLRKDNGS-HKDAEKLESKLKKLQEEYKALLD 179
            :....|:|........:|: :.|.|:...|  ::|.|:|.. :|....:.:.....|....|:.|
pombe   142 KHQALVKAQDKYHYLCKKV-NYYVSQQNMLFGKELEKNNAKLNKTQNAITASSSDYQSAVAAVRD 205

  Fly   180 KHNPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSV 244
            .:....||:.    .||.:.|:|||.....:|..:.|:..::..:.....|.....::.....||
pombe   206 SYARWTNEWR----STCDKLQDIEEERRHFLKSVMWTFTLLISRSCFNDDQACERIRKNLEQCSV 266

  Fly   245 DKLLEQFVLNKYTGLEKPEMPE-------------LEYVAL----------SSGSRLQQPQV-SA 285
            .:.:.:|:..|.||...|:.|:             :|.|..          :....|.:|.| ||
pombe   267 SQDVLEFIDAKSTGTGIPQPPKFYDYYKGEVPDDSVELVQANFQRAQTKIENDNMPLNRPYVLSA 331

  Fly   286 SASNS--------NSATSIQAALRAGNAATTASGSAVSMDQRGDA------LAAISLGSGSAASG 336
            :|.|.        |:.::||       :.||.|.::   .|.|.:      |:...|.|    ..
pombe   332 TARNESSFENTLPNTPSAIQ-------SLTTVSSNS---SQNGRSSPKKSFLSKFKLTS----RP 382

  Fly   337 SIPFAEDPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTAKQQPSAGAGN 401
            |.|...:....|:.|||..||              .|..|...:|.|.....|  ||.|:.
pombe   383 STPNVGNTAPDALSSPRNDSP--------------LTSAADEQMKHLSLQEEP--KQNPTP---- 427

  Fly   402 FGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSEDTSNQDQTQ- 465
               |..|:..|:.|.....|...:|.:.|:.:.|             ..:.||....|.:.|.|
pombe   428 ---AAPGAFPNSNTLPPRYNELGSLPSPNSVSFT-------------EDSRPNVNTPSRRQQIQE 476

  Fly   466 ------QQPAEALTP--------TASATAIAAASAPGKKQLNATTSEQQLSKSL---NEQEHLQQ 513
                  |....|::|        :.|:..:..:.:|.:...:.:.:..:|.:||   |.:.:...
pombe   477 EFGSVLQMENRAVSPVYDSRKNGSRSSFTLRKSRSPKRPSSSLSQNASRLPRSLTPGNLEPNYDF 541

  Fly   514 TAAATAATTAAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQ 578
            ......|:..|.|.....|.|.::.:.:  |.|::.:|       .|..:.:......:..:
pombe   542 GVRVDPASGTAPTDDEPYTDRDSSFVDD--TINTKATG-------NTSNRLSLPAYPTDGGD--- 594

  Fly   579 EERLTSLDRGNNT-----------LLDYD 596
                ||:|...:|           |.|||
pombe   595 ----TSIDNPTSTDGQRILGYVSALYDYD 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	64/290 (22%)
		Apolipoprotein	52..214	CDD:279749	41/181 (23%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
imp2	NP_596391.1	F-BAR_PombeCdc15_like	24..259	CDD:153335	56/245 (23%)
imp2	NP_596391.1	SH3	610..666	CDD:214620	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	57	1.000	Domainoid score	I3117
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47409
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2080
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940