DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and FCHO1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_001154829.1	Gene:	FCHO1 / 23149	HGNCID:	29002	Length:	891	Species:	Homo sapiens

Alignment Length:	1270	Identity:	340/1270 - (26%)
Similarity:	506/1270 - (39%)	Gaps:	454/1270 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKA--GTLNSTFA 67
            |.::||||||:|::||||::|.|.|::|||::|:||::.|||..||.|:||:..|  ||...|||
Human     4 FGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASNGTPMGTFA 68

  Fly    68 PVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVA 132
            |:|.:.|.|::||:..||::.:||.:|:|||.:|.:|..|.||..|||...||:.||.:...:..
Human    69 PLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVSTLDAVQVLSGVSQL 133

  Fly   133 VQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCK 197
            :.|.|:.|.::..:.|:||:::.|.|:.:|.|:|.||..|..:..::|:|..:.:||::|..:..
Human   134 LPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVEKYNSARADFEQKMLDSAL 198

  Fly   198 RFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKP 262
            |||.:||.|||.||..|.:|...:::.|..:||||.:||:...::||:.||.:|..:|.||.|||
Human   199 RFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKP 263

  Fly   263 EMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALRAGNAATTASGSAVSMDQRGDALAAIS 327
            ...:.|                     :.||.::|.|:
Human   264 GPLDFE---------------------AYSAAALQEAM--------------------------- 280

  Fly   328 LGSGSAASGSIPFAEDPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTAK 392
                                                                 |.||
Human   281 -----------------------------------------------------KRLR-------- 284

  Fly   393 QQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSED 457
                 ||..|.:.|
Human   285 -----GAKAFRLPG--------------------------------------------------- 293

  Fly   458 TSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLNEQEHLQQTAAATAATT 522

Human   294 ----------------------------------------------------------------- 293

  Fly   523 AAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLDR 587
                     .|||                              :::.:..||.:..|
Human   294 ---------LSRR------------------------------EREPEPPAAVDFLE-------- 311

  Fly   588 GNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPNA 652
                                                                          |::
Human   312 --------------------------------------------------------------PDS 314

  Fly   653 GALTNSASITAPGAASGTGTGYEVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQERR 717
            |        |.|          |||||||:::|  ::.  :......|.:|.||:|.| |::.|:
Human   315 G--------TCP----------EVDEEGFTVRP--DVT--QNSTAEPSRFSSSDSDFD-DEEPRK 356

  Fly   718 IHVSIKPLKNGQAPM---SASVDELRATVENISL--SPTGVFSHHSQQLQAARGAPASRQQSPEI 777
            .:|.|||.. .:||.   .|:..:||||..::.|  .|.|....||.  :.|.|.|...:.:|..
Human   357 FYVHIKPAP-ARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSS--RDAAGKPQRPRSAPRT 418

  Fly   778 SNASTPTASVHPYAP-LQSPTLSNNNNANNTTNSRYADLGDIFS----------ELGDMSMSAPS 831
            |:.:....|....:. |..|.|.:..:..:.|.|  :.||...|          .:.|..:.:||
Human   419 SSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGS--SSLGFTSSPSPFSSSSPENVEDSGLDSPS 481

  Fly   832 SATLGKPPGRQIPTPTSASTGGSIAIPRPPSR--RSDMIAIGPAATGTAPG--------RGRMSP 886
            .|..|..|...:|.|.:..:..|...|.|.:|  |:..:...|....::||        .|.:.|
Human   482 HAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMP 546

  Fly   887 APV--TA--------------------------MNRAES---IGSLEFRTAI--------GGVGS 912
            ||.  ||                          ::|:.|   :||....||:        .|.|.
Human   547 APADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHGV 611

  Fly   913 SRGPSPLTIGISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAK 977
            ||||||:.:|..|.:|:|.||.|.:||||||...| |..:|:|::.::|||||..:.:..|.|..
Human   612 SRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS-CLARVTGELTMTFPAGIVRVFSGTPPPPV 675

  Fly   978 LGFRIKHVQNLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILK 1042
            |.||:.|...:|:..||..|:..|..||...:.....||.|||..|:||||.||||||:||.:|:
Human   676 LSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEALQRQAEQNPTASYYNVVLLR 740

  Fly  1043 YQVRTKPGASSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASPLLNVTLSVPVNGSVRNVQSK 1107
            ||. ::||..|.|.||.::|:|.::.|.:.|:|.|...|.|..:||.||.:.:||...|.||:.:
Human   741 YQF-SRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQ 804

  Fly  1108 PHSAWLGESNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPALLATQFNCEGTTLSGIEFEL 1172
            |.:.|..|..||.|...|:   |:.||.|.|.|..|...|||||:.:|.||..|||||||::.||
Human   805 PAATWNLEEKRLTWRLPDV---SEAGGSGRLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLEL 866

  Fly  1173 QGSGYRLSLVKRRFVSGKYVCEGDGIRSGATPTPP 1207
            .|||||:|||||||               ||..||
Human   867 VGSGYRMSLVKRRF---------------ATAAPP 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	107/259 (41%)
		Apolipoprotein	52..214	CDD:279749	64/163 (39%)
		AP_Syp1_like_MHD	928..1194	CDD:271171	120/265 (45%)
FCHO1	NP_001154829.1	Mediates membrane-binding	1..275		113/291 (39%)
		F-BAR_FCHO1	10..270	CDD:153358	108/280 (39%)
		Atrophin-1	<253..562	CDD:331285	96/675 (14%)
		Mediates interaction with the adaptor protein complex AP-2	267..442		63/539 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..352		24/180 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..596		47/217 (22%)
		AP_MHD_Cterm	627..882	CDD:324770	120/274 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	826..849		11/22 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145128
Domainoid	1	1.000	273	1.000	Domainoid score	I1787
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	601	1.000	Inparanoid score	I954
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45895
OrthoDB	1	1.010	-	-		D286007at33208
OrthoFinder	1	1.000	-	-		FOG0001508
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104540
Panther	1	1.100	-	-	LDO	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810