| Sequence 1: | NP_001097723.1 | Gene: | CG8176 / 261329 | FlyBaseID: | FBgn0037702 | Length: | 1220 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_766179.2 | Gene: | Fcho2 / 218503 | MGIID: | 3505790 | Length: | 809 | Species: | Mus musculus |
| Alignment Length: | 1212 | Identity: | 350/1212 - (28%) |
|---|---|---|---|
| Similarity: | 510/1212 - (42%) | Gaps: | 431/1212 - (35%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAGTLN--STFA 67
Fly 68 PVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVA 132
Fly 133 VQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCK 197
Fly 198 RFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKP 262
Fly 263 EMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALRAGNAATTASGSAVSMDQRGDALAAIS 327
Fly 328 LGSGSAASGSIPFAE-DPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTA 391
Fly 392 KQQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSE 456
Fly 457 DTSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLNEQEHLQQTAAATAAT 521
Fly 522 TAAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLD 586
Fly 587 RGNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPN 651
Fly 652 AGALTNSASITAPGAASGTGTGYEVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQER 716
Fly 717 RIHVSIKPL-KNGQAPMSASVDELRATVENISLSPTGVFSHHSQQLQAARGAPASRQQSPEISNA 780
Fly 781 STPTA----SVHPYAPL-------QSPTLSNNNNANNTTNSRYADLGDIFSELGDMSMSAPSSAT 834
Fly 835 LGKPPGRQIPTPTSAS--TGGSIAIPRPPSRRSDMIAIGPAATGTAPGRGRMSPAPVTAMNRAES 897
Fly 898 IGSLEFRTAIGG-----VGSSRGPSPLTIGISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDM 957
Fly 958 MLSFPAGIAGLLANNPNPAKLGFRIKHVQNLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTAL 1022
Fly 1023 LRRQAENNPTASYFNVDILKYQVRTKPGASSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASP 1087
Fly 1088 LLNVTLSVPVNGSVRNVQSKPHSAWLGESNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPA 1152
Fly 1153 LLATQFNCEGTTLSGIEFELQGSGYRLSLVKRRFVSGKYVCE 1194 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| CG8176 | NP_001097723.1 | F-BAR_FCHO | 11..269 | CDD:153332 | 113/259 (44%) |
| Apolipoprotein | 52..214 | CDD:279749 | 74/163 (45%) | ||
| AP_Syp1_like_MHD | 928..1194 | CDD:271171 | 128/265 (48%) | ||
| Fcho2 | NP_766179.2 | Mediates dimerization and binding to membranes enriched in Pi(4,5)-P2 and induces their tubulation | 3..274 | 120/340 (35%) | |
| F-BAR_FCHO2 | 5..273 | CDD:153357 | 119/339 (35%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 301..352 | 25/144 (17%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 390..422 | 9/34 (26%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 435..536 | 36/136 (26%) | |||
| Mediates interaction with DAB2, EPS15, EPS15R and ITSN1. /evidence=ECO:0000250 | 520..809 | 139/290 (48%) | |||
| FCHo2_MHD | 543..809 | CDD:211378 | 128/267 (48%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 267 | 1.000 | Domainoid score | I1856 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2398 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 589 | 1.000 | Inparanoid score | I990 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG45895 | |
| OrthoDB | 1 | 1.010 | - | - | D286007at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001508 | |
| OrthoInspector | 1 | 1.000 | - | - | otm44261 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104540 | |
| Panther | 1 | 1.100 | - | - | O | PTHR23065 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2080 |
| SonicParanoid | 1 | 1.000 | - | - | X1233 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 14 | 13.870 | |||||