DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8176 and Pstpip1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	XP_006510928.1	Gene:	Pstpip1 / 19200	MGIID:	1321396	Length:	434	Species:	Mus musculus

Alignment Length:	391	Identity:	88/391 - (22%)
Similarity:	161/391 - (41%)	Gaps:	80/391 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FWGE---KNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAG---TLNSTFA 67
            ||..   .:.||:||...:..|....|::.|.||:::..||:..|.:.::|.|||   .:||
Mouse    30 FWCRDFTAHTGYEVLLQRLLDGRKMCKDVEELLRQRAQAEERYGKELVQIARKAGGQTEMNS--- 91

  Fly    68 PVWTILRTS-------AEKLSTLHLQMVQKLTELVKDVAKYAD---ELHKKHKSVKE--EESQTL 120
                 ||||       .|.:.:.|:|:...|.|.::.:.::.:   |..||::::.:  ::|:..
Mouse    92 -----LRTSFDSLKQQTENVGSAHIQLALALREELRSLEEFRERQKEQRKKYEAIMDRVQKSKLS 151

  Fly   121 ECVQAIQTSTVAVQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEE-------YKALL 178
            ...:.:::.....||.||  |...::..:....||..|..||.::|.|:.:|.       |:..:
Mouse   152 LYKKTMESKKAYDQKCRD--ADDAEQAFERVSANGHQKQVEKSQNKAKQCKESATEAERVYRQNI 214

  Fly   179 DKHNPIKNEFERRMTQTCKRFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMS 243
            ::....:.|:|:....||:.||..|...|..::..|..:...|........:::.:.:.......
Mouse   215 EQLERARTEWEQEHRTTCEAFQLQEFDRLTILRNALWVHCNQLSMQCVKDDELYEEVRLTLEGCD 279

  Fly   244 VDKLLEQFVLNKYTGLEKP-EMPELEY----VALSSGSRLQQPQV------------------SA 285
            |:..:..|:.:|.||.|.| .:|...|    |....||...||..                  ||
Mouse   280 VEGDINGFIQSKSTGREPPAPVPYQNYYDREVTPLIGSPSVQPSCGVIKRFSGLLHGSPKTTPSA 344

  Fly   286 SASNSNSAT-----------SIQAALRAGNAATTASG-------SAVSMDQ----RGDALAAISL 328
            .|:::.:.|           ||:.....||..::|..       :|.:.|:    .||.||.|..
Mouse   345 PAASTETLTPTPERNELVYASIEVQATQGNLNSSAQDYRALYDYTAQNSDELDISAGDILAVILE 409

  Fly   329 G 329
            |
Mouse   410 G 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	63/283 (22%)
		Apolipoprotein	52..214	CDD:279749	41/183 (22%)
		AP_Syp1_like_MHD	928..1194	CDD:271171
Pstpip1	XP_006510928.1	F-BAR_PSTPIP1	35..276	CDD:153355	55/250 (22%)
Pstpip1	XP_006510928.1	SH3_PSTPIP1	381..433	CDD:212758	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2080
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840