DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8176 and FCHO2

DIOPT Version :9

Sequence 1:NP_001097723.1 Gene:CG8176 / 261329 FlyBaseID:FBgn0037702 Length:1220 Species:Drosophila melanogaster
Sequence 2:NP_620137.2 Gene:FCHO2 / 115548 HGNCID:25180 Length:810 Species:Homo sapiens


Alignment Length:1208 Identity:346/1208 - (28%)
Similarity:511/1208 - (42%) Gaps:422/1208 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKAGTLN--STFA 67
            |.:.||||||:|:||||||||.|.|::|||::|:||::.|||..|:.|:|||..|...:  .|||
Human     6 FVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFA 70

  Fly    68 PVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVA 132
            |||.:.:||.|||:..||.:|:||.||:|:|.||.:|..|.||..|||.:.|||.||.||:.|.|
Human    71 PVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQA 135

  Fly   133 VQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCK 197
            :||.::.|.:|..|.|:|:|:..:.::.||...|.||..:.||..::|:...|.:||::||:|.:
Human   136 LQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQ 200

  Fly   198 RFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKP 262
            :||:|||.||..:||.:.:....::..|..:||||.:|.....:.:|:.|:::|..:|.||.|:|
Human   201 KFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERP 265

  Fly   263 EMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALRAGNAATTASGSAVSMDQRGDALAAIS 327
            .:.|.|                                                          .
Human   266 GLIEFE----------------------------------------------------------E 272

  Fly   328 LGSGSAASGSIPFAEDPILGAMGSPRPTSPDMLAGANASGIQSQPTGGATSTVKSLRSWFLPTAK 392
            ..:.||..|..|                                         :..:::.||   
Human   273 CDTASAVEGIKP-----------------------------------------RKRKTFALP--- 293

  Fly   393 QQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNNLNTNNTTATTTTTTGTNNLTTNITKNSPNSED 457
                                                                             
Human   294 ----------------------------------------------------------------- 293

  Fly   458 TSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQLSKSLNEQEHLQQTAAATAATT 522
                                                                             
Human   294 ----------------------------------------------------------------- 293

  Fly   523 AAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKKAKKKKDNEAAENIQEERLTSLDR 587
                                        ||:            ||:||.|:.|            
Human   294 ----------------------------GII------------KKEKDAESVE------------ 306

  Fly   588 GNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVDSAGASSMGGSGGAAVASGSLPNA 652
                                                                         .|:|
Human   307 -------------------------------------------------------------CPDA 310

  Fly   653 GALTNSASITAPGAASGTGTGYEVDEEGFSIQPAKEIAWEEGQDKSGSFYSDSDTDSDNDKQERR 717
            .      |:..|          :|||||:||:|..    .:...|...|||.||:||: |::.::
Human   311 D------SLNIP----------DVDEEGYSIKPET----NQNDTKENHFYSSSDSDSE-DEEPKK 354

  Fly   718 IHVSIKPL-KNGQAPMSASVDELRATVENISLSPTGVFSHHSQQLQAARGAPASRQQSPEISNAS 781
            ..:.|||: .|......||:|||:.::.||:|||  ..|.||.       ...:|..|.|....|
Human   355 YRIEIKPMHPNNSHHTMASLDELKVSIGNITLSP--AISRHSP-------VQMNRNLSNEELTKS 410

  Fly   782 TP--------TASVHPYAPLQSPTLSNNNNANNTTNSRYADLGDIFSELGDMSMSAPSSATLGKP 838
            .|        |:.:..:.||..|:|.::::::.|::|             ....:.|.|.....|
Human   411 KPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSS-------------SARPTTPLSVGTIVP 462

  Fly   839 PGRQIPTP--TSASTGGSIAIPRPPSRRSDMIAIGPAATGTAPGRGRMSPAPVTAMNRAESIGSL 901
            |.|....|  ||....|...||||         ..|..|...      ||.|...:.||||..|:
Human   463 PPRPASRPKLTSGKLSGINEIPRP---------FSPPVTSNT------SPPPAAPLARAESSSSI 512

  Fly   902 EFRTAIGG-----VGSSRGPSPLTIGISDTIPLAVAFHEIIHAYFRGSDESRCQVKVSGDMMLSF 961
            ....::..     ||.||||||:::|..||:|:|||..|.::|||:|:|.::|.||::|||.:||
Human   513 SSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSF 577

  Fly   962 PAGIAGLLANNPNPAKLGFRIKHVQNLENLVPNGKLVQIDRQQSSSVSTMLEFNMGALTALLRRQ 1026
            |:||..:..:||.||.|.||:|::..||.::||.:||..|..|..|.:.....||.|:|..|::.
Human   578 PSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKL 642

  Fly  1027 AENNPTASYFNVDILKYQVRTKPGASSCPFQLVSYWKCESSYTALKVDYKYNNHAMASASPLLNV 1091
            :|.||.|||:|||:|||||.:. |..|.|..|.:||||.:|.|.|:||||||..||.:.|.|.|:
Human   643 SEQNPAASYYNVDVLKYQVSSN-GIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNI 706

  Fly  1092 TLSVPVNGSVRNVQSKPHSAWLGESNRLVWNFTDISQNSQDGGVGTLRARLELNDGPSTPALLAT 1156
            .:.|||:|.|.|:||.|.:.|..|..:..|..:.||:.|::||.|:|||:.:|::|||.|..||.
Human   707 QVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAV 771

  Fly  1157 QFNCEGTTLSGIEFELQGSGYRLSLVKRRFVSGKYVCE 1194
            ||..||:||||::|||.|:||||||:|:||.:|:|:.:
Human   772 QFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLAD 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8176NP_001097723.1 F-BAR_FCHO 11..269 CDD:153332 114/259 (44%)
Apolipoprotein 52..214 CDD:279749 74/163 (45%)
AP_Syp1_like_MHD 928..1194 CDD:271171 130/265 (49%)
FCHO2NP_620137.2 Mediates dimerization and binding to membranes enriched in Pi(4,5)-P2 and induces their tubulation 3..274 118/325 (36%)
F-BAR_FCHO2 5..273 CDD:153357 118/324 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..352 24/144 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..537 41/160 (26%)
Mediates interaction with DAB2, EPS15, EPS15R and ITSN1 521..810 141/290 (49%)
FCHo2_MHD 544..810 CDD:211378 130/267 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 273 1.000 Domainoid score I1787
eggNOG 1 0.900 - - E1_KOG2398
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 601 1.000 Inparanoid score I954
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45895
OrthoDB 1 1.010 - - D286007at33208
OrthoFinder 1 1.000 - - FOG0001508
OrthoInspector 1 1.000 - - otm42208
orthoMCL 1 0.900 - - OOG6_104540
Panther 1 1.100 - - O PTHR23065
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2080
SonicParanoid 1 1.000 - - X1233
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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