DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8176 and fcho1

DIOPT Version :9

Sequence 1:	NP_001097723.1	Gene:	CG8176 / 261329	FlyBaseID:	FBgn0037702	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	XP_009302185.1	Gene:	fcho1 / 100913078	ZFINID:	ZDB-GENE-120613-1	Length:	1152	Species:	Danio rerio

Alignment Length:	1307	Identity:	372/1307 - (28%)
Similarity:	579/1307 - (44%)	Gaps:	284/1307 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNDYFWGEKNNGYDVLYHNMKFGLIASKELSEFLREKSNIEEQNSKMMSKLAHKA--GTLNSTFA 67
            |.:.||||||.|:||||||||.|.||:|||:||:||::.|||..||.|||||..|  |:...|||
Zfish     6 FKNNFWGEKNAGFDVLYHNMKHGQIATKELAEFVRERAAIEETYSKSMSKLAKMASNGSPLGTFA 70

  Fly    68 PVWTILRTSAEKLSTLHLQMVQKLTELVKDVAKYADELHKKHKSVKEEESQTLECVQAIQTSTVA 132
            |:|.:.|.|::||:..||::::|:.:|::|:.||:||..|.|:..|||...|||.||::|.....
Zfish    71 PMWDVFRVSSDKLALCHLELMRKMNDLIRDINKYSDEQVKIHRKTKEEAIGTLESVQSLQVQNGH 135

  Fly   133 VQKLRDLYASKVQELEKLRKDNGSHKDAEKLESKLKKLQEEYKALLDKHNPIKNEFERRMTQTCK 197
            :||.|:.|.||..|||:|||:....|:.||.|.|.||..|.:...::|.|....:||::|:::.:
Zfish   136 LQKTREGYHSKCVELERLRKEGVPQKELEKAELKCKKAAESFAGSIEKFNRAGGDFEQKMSESAQ 200

  Fly   198 RFQEIEEVHLRQMKEFLSTYLEMLQNNHDMVGQVHSDFKRQFVDMSVDKLLEQFVLNKYTGLEKP 262
            :||:|||.||||||..:..|...:::.|..|||||.:||:...::.::.|:::|...|.||.|:|
Zfish   201 KFQDIEEAHLRQMKLLIKGYSHSIEDTHVQVGQVHEEFKQNVENIGIENLIQKFTEQKGTGKERP 265

  Fly   263 EMPELEYVALSSGSRLQQPQVSASASNSNSATSIQAALR-------------AGNAATTASGSAV 314
            .....|             :..:|.::.||..|...|.|             ..:|...|..|.:
Zfish   266 GPVGFE-------------EYLSSLASENSKKSRAKAFRIPGLGKRDKEPDSTDSAVADALNSPL 317

  Fly   315 SMDQRGDALAAISLGSGSAA--------SGSIPFAEDPILGAMGSPRPTSPDMLAGANASGIQSQ 371
            .:|..|..:.|....:|.||        |....|.::       .|:...           ||.:
Zfish   318 EVDDEGFVIRADVKQNGCAAEEKEGNFYSSDSDFDDE-------EPKKFH-----------IQIR 364

  Fly   372 PTGGATSTVKSLRSWFLPTAKQQPSAGAGNFGMAGSGSTNNTTTTTTASNNSNN-LNTNNTTATT 435
            |                                            ..:||.||: .|.....||.
Zfish   365 P--------------------------------------------VASSNRSNSAANEQELKATV 385

  Fly   436 TTTTGTNNLTTNITKNSPNSEDTSNQDQTQQQPAEALTPTASATAIAAASAPGKKQLNATTSEQQ 500
            ...|...|...::.|....:..::.:.:.:.:                 |.|.:      ..||:
Zfish   386 GALTLPPNRVVSVKKQLSRNSSSAGRSEGEGE-----------------SVPQR------DGEQE 427

  Fly   501 -LSKSLNEQEHLQQTAAATAATTAAATTATTTTSRRATSLLNIFTSNSQVSGILRSRRDKTKTKK 564
             |.:|.:..:|           :..::||:.:.:.....|.:.|.|:| .||..:.:.....::.
Zfish   428 GLRRSTSSPDH-----------SRLSSTASGSDALFGPPLESAFKSHS-FSGREQLQNAFAASEY 480

  Fly   565 AKKKKDNEAAENIQEERLTSLDRGNNTLLDYDDHGRSMKTQNSSGSSAGGGLAALSVTSAQGSVD 629
            |....|:.:.||::       |.|    ||...|      |....|....|.||...:.:| |.|
Zfish   481 AAFSSDSSSLENVE-------DSG----LDSPSH------QPLGVSPDPTGWAAWPSSQSQ-SKD 527

  Fly   630 SAGASSMGGSGGAAVASGSLPNAGA-------LTN--SASITAPGAASGTGTGYEVDEEGFSIQP 685
            |...|.   |....:|:...|:.|.       .||  .:::.:|.|..      :|:...||. |
Zfish   528 SINLSR---SSDPFLAAFQDPSPGRSPLPQDDTTNVWPSNLRSPRAPP------DVEPTTFSF-P 582

  Fly   686 A--KEIAWEEGQDKSGS---------FYS--DSDTDSDN-------------DKQERRIHVSIKP 724
            |  ..||..|.:....|         |.:  :..|..||             ..:|.|......|
Zfish   583 AFSHSIASSELEPSVWSCKHIPPEDLFLAAFERSTPKDNLPPTDAWAPPPPRPNREARTDPFSVP 647

  Fly   725 LKNGQA-PMSASVDELRATVENISLSP----------TGVFSHHSQQLQAARGAPASRQQSPEIS 778
            |.:.:. |..:|:.:.|....:.|:.|          |.:.|...|.:|||         |....
Zfish   648 LNDTKTLPPPSSLRKERDRKRDRSVPPPESPDDPFAITMIGSPTHQSMQAA---------SQSRG 703

  Fly   779 NASTPTASVHPYAPLQS-PTLSNNNNANN-----TTNSRYADLGDIFSELGDMSMSAPSSATLGK 837
            .::.||.|.:|....|| ..|.:.|:.:|     |||:...            ..|.....:...
Zfish   704 GSNRPTPSPNPAPSSQSKKELVHWNSVHNPFSEGTTNNTVT------------QESTRKQRSFND 756

  Fly   838 PPGRQIPTPTSASTG-------------GSIAIPRPPSRR-------SDMIAIG-PAATGTAPGR 881
            .|.|..| |.:..:|             ..:.|..||..:       |:.:|:. |.:..:....
Zfish   757 EPRRNGP-PLTRHSGPQEDLCFSTDKDQNFLDINTPPVSQHGFRQDSSERLALAPPRSVRSKRSS 820

  Fly   882 GRMS---------------PAP--VTAMNRAESIGSLEFRTAIGGVGSSRGPSPLTIGISDTIPL 929
            ||:|               |:|  .::.:.:.|...::.|......|.||||||:::...::.|:
Zfish   821 GRLSGCERSRSLCSSPLPDPSPPLTSSSSSSPSDWGVQNRVPSPARGLSRGPSPISLSAQESWPV 885

  Fly   930 AVAFHEIIHAYFRGSDESRCQVKVSGDMMLSFPAGIAGLLANNPNPAKLGFRIKHVQNLENLVPN 994
            |.|..|.|:|||||.:.:||.||::||:.:||||||..:...|||...|.||:.::..:::.:||
Zfish   886 AAAITEYINAYFRGGEHNRCLVKITGDLTMSFPAGITRIFTANPNAPVLSFRLVNISRVDHFLPN 950

  Fly   995 GKLVQIDRQQSSSVSTMLEFNMGALTALLRRQAENNPTASYFNVDILKYQVRTKPGASSCPFQLV 1059
            .||:..|..||...:....|||.|||..|:|:||.||.|||:||.:||||..:: ..|..|..|.
Zfish   951 QKLLYSDPSQSDPDTKDFWFNMQALTLHLQREAELNPQASYYNVALLKYQASSQ-DPSRAPLLLS 1014

  Fly  1060 SYWKCESSYTALKVDYKYNNH---AMASASPLLNVTLSVPVNGSVRNVQSKPHSAWLGESNRLVW 1121
            :  :|:.|.|..:|...|  |   |.|.|:.|.:|.:.:|::.|..::|.:|.:||..|..||:|
Zfish  1015 A--ECQRSGTVTRVSLDY--HCCPATAPATQLTSVQVLLPLDHSATDLQCQPPAAWNAEERRLLW 1075

  Fly  1122 NFTDISQNSQDGGVGTLRARLELNDGPSTPA-LLATQFNCEGTTLSGIEFELQGSGYRLSLVKRR 1185
            ...::|..:...|.|||.|..:..:.|..|| .||.||...|.:|||::.||.||.||:||||:|
Zfish  1076 KLANLSPTNHSKGSGTLCASWQCLEVPRGPAPSLAVQFVGSGASLSGLDVELVGSRYRMSLVKKR 1140

  Fly  1186 FVSGKYV 1192
            |.:|||:
Zfish  1141 FATGKYM 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8176	NP_001097723.1	F-BAR_FCHO	11..269	CDD:153332	116/259 (45%)
		Apolipoprotein	52..214	CDD:279749	72/163 (44%)
		AP_Syp1_like_MHD	928..1194	CDD:271171	112/269 (42%)
fcho1	XP_009302185.1	F-BAR_FCHO1	12..272	CDD:153358	117/272 (43%)
fcho1	XP_009302185.1	FCHo1_MHD	884..1149	CDD:271173	112/269 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578443
Domainoid	1	1.000	226	1.000	Domainoid score	I2457
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	592	1.000	Inparanoid score	I943
OMA	1	1.010	-	-		QHG45895
OrthoDB	1	1.010	-	-		D286007at33208
OrthoFinder	1	1.000	-	-		FOG0001508
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104540
Panther	1	1.100	-	-	LDO	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910