Protein Alignment PRPF31 and prpf31

DIOPT Version :10

• Sequence 1: NP_056444.3
• Gene: PRPF31 / 26121
• HGNCID: 15446
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_998859.1
• Gene: prpf31 / 407890
• XenbaseID: XB-GENE-489336
• Length: 498
• Species: Xenopus tropicalis
• Alignment Length: 498
• Identity: 452/498 - (90%)
• Similarity: 478/498 - (95%)
• Gaps: 1/498 - (0%)

Human     1 MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMFAEIMM 65
            |||||||||||||||||||.....|::.| .||:||||.|:||:.:|||:||||.|||:|:||::
 Frog     1 MSLADELLADLEEAAEEEEENLIDEDDLE-TIEEVQEEMQVDLNAESVKSIAKLSDSKLFSEILL 64

Human    66 KIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVP 130
            ||:.||.||.|||||||||||||||:|||||||||||||||||||||||||||||||||||||||
 Frog    65 KIDGYIKKQPKASEVMGPVEAAPEYKVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVP 129

Human   131 NALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMAL 195
            ||||||||||||||:||||||||||||||||||||||||||||||||||::|||||:||||||||
 Frog   130 NALDYIRTVKELGNNLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLTDEELERIEEACDMAL 194

Human   196 ELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLS 260
            |||.|||||||||||||||||||||||:||||||||||:||||||||||||||:|||||||||||
 Frog   195 ELNQSKHRIYEYVESRMSFIAPNLSIIVGASTAAKIMGIAGGLTNLSKMPACNVMLLGAQRKTLS 259

Human   261 GFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIE 325
            |||||||||||||||||||||||||||.|||||||:|||||||||||||||:||||||:||:|||
 Frog   260 GFSSTSVLPHTGYIYHSDIVQSLPPDLHRKAARLVSAKCTLAARVDSFHESSEGKVGYDLKEEIE 324

Human   326 RKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQE 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
 Frog   325 RKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFAEIEEDAYQE 389

Human   391 DLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFT 455
            ||||||||||||||||:||.|||||||||||||||||||||||||||||||||||||||||||||
 Frog   390 DLGFSLGHLGKSGSGRIRQAQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFT 454

Human   456 PLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMS 498
            |||||||||||||||||||||||||||||||||||.||||.|:
 Frog   455 PLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKSEKSGTMT 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF31	NP_056444.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		24/35 (69%)
		Nop	100..330	CDD:460335	216/229 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..357		22/22 (100%)
		Prp31_C	337..465	CDD:462898	124/127 (98%)
		Nuclear localization signal (NLS). /evidence=ECO:0000269|PubMed:12444105	351..364		12/12 (100%)
prpf31	NP_998859.1	Nop	99..329	CDD:460335	216/229 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	333..356		22/22 (100%)
		Prp31_C	336..464	CDD:462898	124/127 (98%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:Q8WWY3	350..363		12/12 (100%)