Protein Alignment TANC2 and CG10011

DIOPT Version :10

• Sequence 1: XP_011522899.1
• Gene: TANC2 / 26115
• HGNCID: 30212
• Length: 2075
• Species: Homo sapiens
• Sequence 2: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Alignment Length: 2021
• Identity: 412/2021 - (20%)
• Similarity: 660/2021 - (32%)
• Gaps: 638/2021 - (31%)

Human   138 DVDAYCPGDAEQELGPPPSVDEAANTLMTR--------LGFLLGEKVT---EVQPGDQYSMEVQD 191
            ||..:..|:......|.....|||..|.|:        |..|:..||:   ||. |..:|..|:.
  Fly   220 DVAHHANGETNGGSAPEEDGQEAAGGLKTQPTEDTDGNLEALMQRKVSPDKEVN-GLVHSAGVEP 283

Human   192 ENQTSA--------ITQRISPCSTLTSSTA----SPPASSPCSTLPPISTNATA---KDCSYGAV 241
            .|:..:        :.::|:.|  |...||    .|.|....::...:|..|.|   ...||...
  Fly   284 NNRIVSTVYIHREWVLKKIALC--LEQRTAGKKSGPVALGGAASSSYVSARAKAAAISSSSYNGC 346

Human   242 ----------TSPTSTLESRDSG-------------------------------IIATLTSYSEN 265
                      ||....:...:||                               |:..|.|::..
  Fly   347 LVLGSNGSGKTSICQAIMKGNSGTKGILNRKLLACYLIESQNPECHSLSLFMRKIVLQLLSHASL 411

Human   266 VERTKYAGESSKELGSGGNI--KPWQSQKSSMDSCLYRV-------------------------- 302
            :.|    .||.:.:..|.:.  ...|.|:..:|..:..:
  Fly   412 ISR----DESQRIIDEGFSFLRDEAQQQEFKLDEAMNNISLSENAEELLIEELKRGASECDTKEL 472

Human   303 DENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRT 367
            |...:..|.::||...   .|:..|..:..||..|...||...|.|.:         ..|.|.|.
  Fly   473 DNFQSQRTSTVNKAAR---TTLTRQQSEPAPLQAMDAVNSDEKTGSNY---------GTHPPKRA 525

Human   368 SLRM----PRQSMGGARTQ-QDLRVRFAPYRPPDIS---------------LKPLLFEVPSITTE 412
            |...    ..:.||..:.| |....:..|...|..|               |.|......|...:
  Fly   526 SRERGDTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGVLSPSKLATISNGGQ 590

Human   413 SVFVG---------RDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMR 468
            |:..|         .|...|||:|.::.......|                          ....
  Fly   591 SIQQGGGEDIADLNTDQEKHEIEAAIKDDKVEEPQ--------------------------ANNE 629

Human   469 QIASDSPHAS-------PKHVDANRELPLTQPPSAHSSITSGSCP----GTPEMRRRQEEAMRRL 522
            ....|.|.|.       .:.:|.:.:.|..:.....::..|.:.|    ....:..:|||.  :|
  Fly   630 DKKEDKPEADKELNDQLKEELDKSSQEPKEEETKEEATADSSAEPLIDFTESNVNGKQEEP--QL 692

Human   523 ASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMA 587
            ...|.......:.|.....:|:      ...||:.....|.|.||..|.:...||:.:..::|..
  Fly   693 KPPVPGEKPRISTNTLPPPLPK------TKSCRTIIADGYYELLLSNPEILECLSVDNIEKNPDE 751

Human   588 SFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDT---------------IVSFLS 637
            .|::..|.||..|..    |....::|||.::|...::.:...|               :...||
  Fly   752 CFKKAFLFPLLELTP----PKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLS 812

Human   638 KMIGKFPSWLKLIVTVRTSLQEITKLLP-FHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNN 701
            ..|..||.||.|:.|.:...::|||:.. |.:|.||.|.::..: :|:|.||::|:  :|:.:::
  Fly   813 NHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSHVV-KDVQEYIINRL--NSDFKDS 874

Human   702 ISLNGKMDNTTFGKLSSH-LKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQC 765
            |.|..::..      |.| |...|.|..|||:.....|:..:...:  ..|::|.:|:.:||..|
  Fly   875 IMLTKEIIE------SLHQLYIKSNGCILYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYIC 931

Human   766 NMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRR 830
            ...| .:..:.::.|||||.:||...:....:|..:...:.  |::.::|::|::.:...|....
  Fly   932 QKSF-NKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNY--TIDCQEFEKRLQLMRNILAYDS 993

Human   831 DMTRMFV-HPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKA- 893
            :..|:.: |.||.:||:..:...| ||:||...||.:::.::......|.........:|::::
  Fly   994 NAQRLKIFHNSFADWLVDVKFATK-KFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSG 1057

Human   894 ---------------------------------------HIFKGLSKKVGVSSSILQGLWISYST 919
                                                   |.||.....:..:.::|:....|..:
  Fly  1058 EYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKTRAMLERFLASELS 1122

Human   920 EGLSMALASLRNLYTPNI----KVSRLLILGGAN------------------------------- 949
            |..:..|.   :.:.|::    |:.:|||..|.|
  Fly  1123 EPFAQFLC---DFFKPSLPTDAKMLKLLIETGINNAESQNSCESSLMSPELSEKSQNIDFELADL 1184

Human   950 ----------------------------------------------------------------- 949
                                                                             
  Fly  1185 LLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQ 1249

Human   950 ------------INYRTEVLNNAPILCVQSHLGYTEMVALLLEFG------------ANVDASSE 990
                        |:...|..|....|.:.:..|:.|:|.|||.|.            .:|:.:..
  Fly  1250 LLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADR 1314

Human   991 SGLTPLGYAAAAGYLSIV-VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM-AG 1053
            .|.|||..|:..|:..:| :|:.:...|:|..||.|:.||..||..||.:::|.||:....: :.
  Fly  1315 DGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSV 1379

Human  1054 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA-- 1116
            .:||        :.:||||:.||:.:||..||:         ..|.:|..| |.|.:||..||
  Fly  1380 DRQG--------RTSLIAASYMGHYDIVEILLE---------NGANVNHLD-LDGRSALCVAALC 1426

Human  1117 -GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMM 1180
             ..|..:|...||:.||...|.:..|..||..:..:|:.::.:|||.:.||.::||..|||||..
  Fly  1427 GSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWA 1491

Human  1181 AASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLD 1245
            |.:.||...|..||..|..|..||.||.|.||....:|::..||.|:|.|....|.|..|.|||.
  Fly  1492 ACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLH 1556

Human  1246 LAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA------------------------------ 1280
            .|||.|..||...|::.||.|:..|..|...|..|
  Fly  1557 YAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTA 1621

Human  1281 --VGC-------------------------RNT-------------------------------- 1286
              :.|                         |.|
  Fly  1622 FRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGR 1686

Human  1287 ------------SVVVTLLKKGAKIGCQTLPSR-PRGPATWAMATSKPDIMIILLSKLMEEGDMF 1338
                        .:|.||::.||.:....|.:| |.....|   ....|:|.|||
  Fly  1687 TALHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAW---QGNHDVMNILL---------- 1738

Human  1339 YKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFG------MAEEF 1397
            |.......|.::...||....:||        .|..|..||.......|.:..|      .|:..
  Fly  1739 YYGALADHACKQGATALGISAQEG--------HEKCVIALLQFGANPYKSDHCGRTPIKLAAKSS 1795

Human  1398 ATKALELKPKSYEAYYARARAKRSSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQ 1462
            .|..|    |.:|:|                   ..|||..  ||..       :.......::.
  Fly  1796 RTSIL----KIFESY-------------------TKNEASN--PNEP-------KFHAHASMLRS 1828

Human  1463 PQQPPPPPQPQQQLPEEAEPEPQHEDIYSV------QDIFEEEYLEQDVENVSIGLQTEARPSQG 1521
            |.|||..|     |.:...|.|.|....||      ..:....:|.  |.|.|....:.....|.
  Fly  1829 PDQPPALP-----LHQNLAPYPAHASASSVCSAATTATVHNGSHLH--VLNASSSTHSSNNFYQN 1886

Human  1522 LPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPS 1586
              .:||..|| .|:..:.|||...||..  |....:......||:..|:...|....:::....:
  Fly  1887 --TMQSDTSS-LHKRKSVISSQSTGSSN--DQAPLTFTQQLQRQSKLSSRNNLMVNSKHASSSGA 1946

Human  1587 PPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQ 1651
            ..|.|....||:.|.|                         :..|......:..:.:.....|..
  Fly  1947 AGHKSSGGGGGAQRHS-------------------------QVLPDLSEHQLASNMTNEADMYDM 1986

Human  1652 ETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQ--------GLRL------QPAKAQIV---- 1698
            |.........|.||.|:::. |.|:|.|...|..:        |.:|      :....:|:
  Fly  1987 ECMSPLYATPPHSPSSELSS-PGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILGNL 2050

Human  1699 RSNQPS 1704
            :.||||
  Fly  2051 KENQPS 2056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TANC2	XP_011522899.1	PHA03095	930..>1224	CDD:222980	101/422 (24%)
		ANK repeat	963..989	CDD:293786	9/37 (24%)
		ANK repeat	991..1022	CDD:293786	10/31 (32%)
		ANKYR	1100..1299	CDD:440430	80/302 (26%)
		ANK repeat	1108..1138	CDD:293786	12/32 (38%)
		ANK repeat	1140..1171	CDD:293786	9/30 (30%)
		ANK repeat	1174..1204	CDD:293786	13/29 (45%)
		ANK repeat	1206..1237	CDD:293786	12/30 (40%)
		ANK repeat	1239..1270	CDD:293786	14/30 (47%)
		ANK repeat	1272..1302	CDD:293786	11/130 (8%)
		TPR repeat	1331..1356	CDD:276809	3/24 (13%)
		TPR	1335..>1450	CDD:440225	23/120 (19%)
		TPR repeat	1361..1404	CDD:276809	11/48 (23%)
		TPR repeat	1409..1438	CDD:276809	5/28 (18%)
		PHA03247	<1512..1741	CDD:223021	41/211 (19%)
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	76/270 (28%)
		ANK repeat	1270..1313	CDD:293786	10/42 (24%)
		ANK repeat	1315..1347	CDD:293786	10/31 (32%)
		ANK repeat	1349..1380	CDD:293786	10/30 (33%)
		ANK repeat	1382..1413	CDD:293786	14/47 (30%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		ANKYR	1469..1788	CDD:440430	82/339 (24%)
		ANK repeat	1484..1515	CDD:293786	13/30 (43%)
		ANK repeat	1517..1548	CDD:293786	12/30 (40%)
		ANK repeat	1550..1581	CDD:293786	14/30 (47%)
		ANK repeat	1617..1648	CDD:293786	1/30 (3%)
		ANK repeat	1650..1682	CDD:293786	2/31 (6%)
		ANK repeat	1684..1715	CDD:293786	5/30 (17%)
		ANK repeat	1717..1742	CDD:293786	9/37 (24%)
		ANK repeat	1750..1775	CDD:293786	8/32 (25%)