DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TANC2 and rols

DIOPT Version :10

Sequence 1:XP_011522899.1 Gene:TANC2 / 26115 HGNCID:30212 Length:2075 Species:Homo sapiens
Sequence 2:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster


Alignment Length:1467 Identity:554/1467 - (37%)
Similarity:786/1467 - (53%) Gaps:215/1467 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    12 GGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGMQHIR 76
            |.:|:..|.|:...|.....||::..:.....|.:.|.|:|:                       
  Fly   591 GKESNALNTSTCSDSAVTRRRRKNVSNHNLKTSARHGASSEN----------------------- 632

Human    77 IMEGMSR-SLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSPTLTSAQKLDVD 140
               .::| ||..:.:......|:....:|.|.:       |.|..  .||.|...|..:..:|..
  Fly   633 ---RLNRLSLAGTSVYAGHLSSLVFGKIKSLWS-------VNSSN--SSEAGLNQLAGSDAIDHH 685

Human   141 AYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPC 205
            :....:..|:           :.|..|||.||.:      ||                       
  Fly   686 SSFLNEKLQK-----------DQLHARLGLLLND------PG----------------------- 710

Human   206 STLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIATLTSYSENVERTK 270
                |:..|..:.|.|.   |||.::|            |||..|...|..:|.||         
  Fly   711 ----SNGNSSSSGSGCE---PISAHST------------TSTTSSSGVGAASTTTS--------- 747

Human   271 YAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLY 335
                     ||..|:.|.|:..|                  ....:....|....|..|:...|.
  Fly   748 ---------GSSQNVSPEQTLAS------------------GAGMLSGSQLSVATSHGVKEDALS 785

Human   336 LMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDL--RVRFAPYRPPDIS 398
            |..:  ..|..|..|:.: |...:.|...:|.|.|..:.|...|.....:  ||..:......::
  Fly   786 LCGK--FKAGCSMLHVYE-ALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAAVQLA 847

Human   399 LKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCH 463
            ||||.||||....:..:|||.|:..::...|..:...|   |:|.|..|.||||...:||..||.
  Fly   848 LKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRV---VLINGQPGTGKTAFCLQLVEYSCF 909

Human   464 GTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGS-CPGTPEMRRRQEEAMRRLASQVV 527
            |.|..|                     ..|...:|.:..|: |           |.||.|||.:|
  Fly   910 GRRQMQ---------------------DDPDGIYSQLQLGAHC-----------ERMRGLASHMV 942

Human   528 AYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRG 592
            .||:||||...||.||:|||::||.||::|||||||:.||.|||||.:||:|.|:.|.....:..
  Fly   943 GYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLA 1007

Human   593 VLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSL 657
            :||||.:||:..|||.:..:|::|.|.|||:|:||:|.||.|||:::...||:||||:.||||.:
  Fly  1008 ILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQM 1072

Human   658 QEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFG-----KLS 717
            .|:.|...:.::.||....::|:.||:..||..|:..|.||:.||. .|...|:..|     |..
  Fly  1073 LELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIG-GGGGQNSQSGSQPQTKFV 1136

Human   718 SHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLL 782
            |||::||:||.||.||..|||.:|.||:|||||||:||||::::||..|::|||..||::..|:|
  Fly  1137 SHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPIL 1201

Human   783 NVAVASLHPLTDEHIFQAINAGSIEG--TLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWL 845
            |:.:|:|:|||.:.|:.::.|.| .|  .|.|.||.||.:.|..|||||.|.|.||.|.|.||||
  Fly  1202 NICLAALYPLTLDEIYYSMEALS-HGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWL 1265

Human   846 IWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSIL 910
            :.|:|||..|||||.|.||..:||..||.:..|:.|.|:|||||:||||::.|.|..: :|...|
  Fly  1266 MRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTL-LSPRDL 1329

Human   911 QGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMV 975
            |..|::.:.:.:|.:|.:|||:|:||:|||||::|.||:.|:||:.:..|||||:.:|.|...||
  Fly  1330 QSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILPMV 1394

Human   976 ALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEV 1040
            :|||||||:|..::..|.|||..||..|:..:|..|....:.:..||...:|||||||..|||.|
  Fly  1395 SLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSV 1459

Human  1041 VKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDS 1105
            ||:|:.|||:.....|.| .:|.|:|||||.||:..:.:|:..||||.|.:.:    ..:|..:.
  Fly  1460 VKYLLACDWSPRPHSQDV-TRSVALQQALIGAAAQAHCKILEDLLDLNETEFD----LDVNGMEP 1519

Human  1106 LWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1170
            ..||.||||||..|.::|..:||.:||.:...||:|...|:..|::|||.:|:.||..||.::..
  Fly  1520 SSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEP 1584

Human  1171 DKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1234
            ..|.| ||||:||.||||..||.|||:||.....|.||.||||||||:|||:..::|:::|....
  Fly  1585 LGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRH 1649

Human  1235 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1299
            |.|.||||.|||||:.|.|.:|.::::.|..:||:|..||||||||:.|||...|...|:||||:
  Fly  1650 HEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKL 1714

Human  1300 GCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFG 1364
                      ||.||:||..||:|::|||:||:|:|::.|:|.:.:|||.||||||:|.  .|..
  Fly  1715 ----------GPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKI--SGLE 1767

Human  1365 EDLK---TFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSSRQF 1426
            :.|:   .|.:|:.:||||||||:||:|:...:.:.||:|:..||.|||.|||||:| |......
  Fly  1768 QLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKA-RMELGAL 1831

Human  1427 AAALEDLNEAIK-------LCPNNREIQRLLLRVEEE 1456
            ..||.|.|||::       ||    |:..:|.|::.|
  Fly  1832 NEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TANC2XP_011522899.1 PHA03095 930..>1224 CDD:222980 139/294 (47%)
ANK repeat 963..989 CDD:293786 14/25 (56%)
ANK repeat 991..1022 CDD:293786 9/30 (30%)
ANKYR 1100..1299 CDD:440430 97/199 (49%)
ANK repeat 1108..1138 CDD:293786 14/29 (48%)
ANK repeat 1140..1171 CDD:293786 11/30 (37%)
ANK repeat 1174..1204 CDD:293786 18/30 (60%)
ANK repeat 1206..1237 CDD:293786 16/30 (53%)
ANK repeat 1239..1270 CDD:293786 15/30 (50%)
ANK repeat 1272..1302 CDD:293786 17/29 (59%)
TPR repeat 1331..1356 CDD:276809 13/24 (54%)
TPR 1335..>1450 CDD:440225 52/124 (42%)
TPR repeat 1361..1404 CDD:276809 18/45 (40%)
TPR repeat 1409..1438 CDD:276809 15/28 (54%)
PHA03247 <1512..1741 CDD:223021
rolsNP_729778.1 zf-RING_5 327..364 CDD:434085
Ank_2 1382..1467 CDD:463710 39/84 (46%)
ANK repeat 1382..1408 CDD:293786 14/25 (56%)
ANK repeat 1410..1441 CDD:293786 9/30 (30%)
ANKYR 1481..1714 CDD:440430 111/236 (47%)
ANK repeat 1486..1518 CDD:293786 12/35 (34%)
ANK repeat 1521..1552 CDD:293786 14/30 (47%)
ANK repeat 1554..1586 CDD:293786 11/31 (35%)
ANK repeat 1591..1619 CDD:293786 17/27 (63%)
Spy 1608..>1847 CDD:443119 120/251 (48%)
ANK repeat 1621..1652 CDD:293786 16/30 (53%)
ANK repeat 1654..1685 CDD:293786 15/30 (50%)
ANK repeat 1687..1712 CDD:293786 14/24 (58%)
TPR repeat 1736..1768 CDD:276809 16/33 (48%)
TPR repeat 1773..1810 CDD:276809 16/36 (44%)
TPR repeat 1815..1843 CDD:276809 15/28 (54%)
Blue background indicates that the domain is not in the aligned region.

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