Protein Alignment TANC2 and tanc2b

DIOPT Version :10

• Sequence 1: XP_011522899.1
• Gene: TANC2 / 26115
• HGNCID: 30212
• Length: 2075
• Species: Homo sapiens
• Sequence 2: XP_073774149.1
• Gene: tanc2b / 335127
• ZFINID: ZDB-GENE-030131-7067
• Length: 2164
• Species: Danio rerio
• Alignment Length: 2246
• Identity: 1527/2246 - (67%)
• Similarity: 1738/2246 - (77%)
• Gaps: 253/2246 - (11%)

Human     1 MFRNSLKMLLTGGKSSRKNR-SSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVP 64
            ||:|||||||||||::||:| |||||:|:..|.:.:::|...|.:|.|| |.:|||.||..|:|.
Zfish     1 MFKNSLKMLLTGGKANRKSRISSDGGNEDGGDLQSAALDPFHSYTGPGG-SVDSDCVFEGGYSVA 64

Human    65 PLPVSEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSP 129
            ||..:||.||:|.|||:|||||||||||||                               :.|.
Zfish    65 PLSATEGFQHMRAMEGVSRSLPSSPLLTHQ-------------------------------ISSS 98

Human   130 TLTSAQKLDVDAYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQ 194
            .|.||:|:...|  .|....||||||||||||||||||||||||:||:|.....|:|||..|:.|
Zfish    99 HLPSARKIFSTA--TGGIGAELGPPPSVDEAANTLMTRLGFLLGDKVSEGSEEPQFSMEEPDDAQ 161

Human   195 TSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIATL 259
            ....:.|:|||||||||||||||.|||||||..:...        ||||||||||||||||||||
Zfish   162 GFGASGRMSPCSTLTSSTASPPACSPCSTLPSAAPGQ--------AVTSPTSTLESRDSGIIATL 218

Human   260 TSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETV 324
            |:|||.::|:...|:.|:    |.::|.|.|.:|::||.||||||||||||:|||||||   .:.
Zfish   219 TNYSEPMDRSGKHGDGSR----GSSLKLWHSHRSTLDSSLYRVDENMTASTFSLNKIPE---PSS 276

Human   325 LSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLR--- 386
            :..|....||||||||||||||||||||||||||||||.||||||||||||....|:.||||
Zfish   277 VHYSSHPTPLYLMPRPNSVAATSSAHLEDLAYLDEQRHAPLRTSLRMPRQSSTAGRSGQDLRASA 341

Human   387 ---------VRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVI 442
                     :|.||||..||:||||||||||||.:|||.||||:|.||||.|:|:::..:.|||:
Zfish   342 NSHAWQSQSLRLAPYRLQDIALKPLLFEVPSITMDSVFTGRDWLFQEIDACLRSTHSGSSAGVVL 406

Human   443 VGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPG 507
            ||||||||||||||||||||||.||||||||||.|||||.|.   :||:||..:|.::..|||||
Zfish   407 VGNIGFGKTAIISRLVALSCHGNRMRQIASDSPQASPKHGDG---IPLSQPQPSHGTLGGGSCPG 468

Human   508 TPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHL 572
            ||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||.||:|||:
Zfish   469 TPEMRRRQEEAMRRLAAQVVAYHYCQSDNAYTCLVPEFVHNVAALLCRSPQLTAYRELLLKEPHI 533

Human   573 QSMLSLRSCVQDPMASFRRGVLEPLENLHKERKI-PDEDFIILIDGLNEAEFHKPDYGDTIVSFL 636
            |||||||||||||..:|||||||||..|:||||| |:||.|||||||||||||||||||||||||
Zfish   534 QSMLSLRSCVQDPPTAFRRGVLEPLHALYKERKITPEEDLIILIDGLNEAEFHKPDYGDTIVSFL 598

Human   637 SKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNN 701
            .|.|.|||:||||:|||||:||||||.||||:|.||.||||:|||.|||.|||||||||:|||||
Zfish   599 CKTINKFPAWLKLVVTVRTTLQEITKPLPFHQISLDALEENDAIDHDLQGYILHRIHSSAEIQNN 663

Human   702 ISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCN 766
            |||||||||::|||||||||.|||||:|||||||||||:||||||||:||||||||:||||||||
Zfish   664 ISLNGKMDNSSFGKLSSHLKALSQGSFLYLKLTFDLIERGYLVLKSSNYKVVPVSLAEVYLLQCN 728

Human   767 MKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRD 831
            |:|||||||:|.:|||||.:|||||||||.|:||||.||::|||:|:||||||||||:||:||||
Zfish   729 MRFPTQSSFERALPLLNVGLASLHPLTDEQIYQAINGGSVKGTLDWDDFQQRMENLSVFLVKRRD 793

Human   832 MTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIF 896
            .|||||||||||||||||||||||||||||:|||||||||||||.||||||||||||||||||||
Zfish   794 GTRMFVHPSFREWLIWREEGEKTKFLCDPRNGHTLLAFWFSRQENKLNRQQTIELGHHILKAHIF 858

Human   897 KGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAP 961
            ||||||||||||||||||:|||||.||.||:||||||||||||||||||||||:|||||||||||
Zfish   859 KGLSKKVGVSSSILQGLWVSYSTESLSTALSSLRNLYTPNIKVSRLLILGGANVNYRTEVLNNAP 923

Human   962 ILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQ 1026
            :|||.:||||.:||.||||.||.||:.|||||||||||||||:||||..|||::||:|||||:||
Zfish   924 VLCVHAHLGYADMVNLLLENGAGVDSPSESGLTPLGYAAAAGHLSIVTSLCKRKAKLDHLDKHGQ 988

Human  1027 CALVHAALRGHLEVVKFLIQCDW-----------------TMAGQQQGV---------------- 1058
            ||||||||||||:|:|||||.||                 :...|.|..
Zfish   989 CALVHAALRGHLDVLKFLIQNDWGQTHLQSPSPTQSQDTPSPVSQPQATPSPTPPDATPSPTQAT 1053

Human  1059 ------------------------------------------------------FKKSHAIQQAL 1069
                                                                  |.||.||||||
Zfish  1054 PTESPPSGPEQQEDPAETPQEEEQNREESPKEEVEKQTQEDTQAERSSSPSSVSFNKSIAIQQAL 1118

Human  1070 IAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAV 1134
            ||||||||||||||||||||:|||:::||||||.|:|||||||:||||||||||||||||||:||
Zfish  1119 IAAASMGYTEIVSYLLDLPERDEEDIQRAQINSCDTLWGETALSAAAGRGKLEVCRLLLEQGSAV 1183

Human  1135 AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGAS 1199
            |||||||.:||||:||||||||||||::||||||:||||||||||||||||||.||:||:|||||
Zfish  1184 AQPNRRGVLPLFSSVRQGHWQIVDLLVSHGADVNLADKQGRTPLMMAASEGHLDTVEFLMAQGAS 1248

Human  1200 IALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1264
            :.|||||||||||||||||||||||.||:.|||||||||||||||||||||||::||||||||||
Zfish  1249 MDLMDKEGLTALSWACLKGHLSVVRCLVERGAATDHADKNGRTPLDLAAFYGDSDVVQFLVDHGA 1313

Human  1265 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPR-GPATWAMATSKPDIMIILL 1328
            ::||||||||||||||||||||||||.|||||||||||||||..: |||||||||||||||||||
Zfish  1314 LVEHVDYSGMRPLDRAVGCRNTSVVVALLKKGAKIGCQTLPSPHKGGPATWAMATSKPDIMIILL 1378

Human  1329 SKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGM 1393
            |||:||||.|||||||||||||||||||||||||..||||||:||||||.|||||||||||||||
Zfish  1379 SKLLEEGDGFYKKGKVKEAAQRYQYALKKFPREGLSEDLKTFKELKVSLFLNLSRCRRKMNDFGM 1443

Human  1394 AEEFATKALELKPKSYEAYYARARAKRSSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECR 1458
            ||||||||||||||||||:|||||||| ||||||.||:||.||||||||||||||||.|||||.|
Zfish  1444 AEEFATKALELKPKSYEAFYARARAKR-SSRQFAEALDDLREAIKLCPNNREIQRLLQRVEEEYR 1507

Human  1459 QMQQPQ----QPPPPPQPQQQLPEEAE--------PEPQHEDIYSVQDIFE-EEYLEQDVENVSI 1510
            |:.|.:    :|||.|.|.....||.|        |||:.:|:..|||:|| :::|||::|.|||
Zfish  1508 QVTQSEELELEPPPSPPPSPLPVEEDEEPPRHTPPPEPRLDDMEPVQDLFEDDDFLEQELEAVSI 1572

Human  1511 GLQTEARP-SQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFR-SSSSVGSPTRQTYQSTSPA 1573
            ||.::.|. :..|.:|:|||.||.|.|:.|:|..     |.|:|. ||||:.|||..:||||||.
Zfish  1573 GLASDIRSNTSSLAIIRSPPLSPAHHDTGYLSGG-----QAFEFHPSSSSMSSPTHHSYQSTSPC 1632

Human  1574 LSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGG---QGKEYPSPPPSPLRRGPQYRASPPAES 1635
            :||||||||||.|||||||||| .||||||||:||   ||.:|.||||||||||..:|||||.||
Zfish  1633 ISPTHQNSHYRQSPPHTSPAHQ-SSYRFSPPPMGGGGNQGMDYQSPPPSPLRRGVPFRASPPVES 1696

Human  1636 MSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKM-AQRPYQMPQLPVAVPQ-------QGLRLQP 1692
            :.:||||||||||||||    .||.||||||.|| :||.:|:...|....|       |||||||
Zfish  1697 VCIYRSQSGSPVRYQQE----PLPSRPKSPLLKMSSQRSFQLQSQPSQSSQTSQHHQVQGLRLQP 1757

Human  1693 AKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVS---QSRLVYQGSIGGIVG 1754
            :.|||||:||||.:|          |.|:||.::|:||.|..|:...   :.|||||.|:
Zfish  1758 SMAQIVRTNQPSNSV----------YSQLAHPLSSRYQGSSMDVDRDRDREPRLVYQPSL----- 1807

Human  1755 DGRPVQHVQASLSAGAICQHGG-----------LTKEDLPQRPSSAYR------GGVRYSQTPQI 1802
            |||.:..||:|||.||:|||||           |.|::|||||:||||      ||:|:||||||
Zfish  1808 DGRSMSQVQSSLSVGALCQHGGRGGPSGVLESNLGKDELPQRPASAYRSATGGPGGMRFSQTPQI 1872

Human  1803 GRSQSASYYPVCHSKLDLERSSS-------QLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHS 1860
            .|||||:||||  ||.:|||:.:       |||||::.||:|||||.|.:::|.|.||||||:||
Zfish  1873 SRSQSAAYYPV--SKHELERAVAASALPPCQLGSPEIPHLVRRPISANTSDLKQHVPTPRPLIHS 1935

Human  1861 QSVGLRFSPSSNSISSTS--NLTPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGG-YPSEP 1922
            |||.|||||||::|||.|  ||...||||||:.||||||:.|||||.||.|.:||:|.| |..||
Zfish  1936 QSVNLRFSPSSSNISSGSSCNLASGFRPSSSMAQMEIPLQVAYERSFDEPSALSPSQSGHYSGEP 2000

Human  1923 TRSRTTPFMGIIDKTAR-TQQYPHLHQQNRTWAVSSVDTVL-SPTSPGNL----PQPESFSPPSS 1981
            ||||||||||:|||||| ||||  |||.:|.|.|||:::|: ||||||||    ....|:|||:|
Zfish  2001 TRSRTTPFMGVIDKTARTTQQY--LHQPSRAWPVSSLESVITSPTSPGNLIHQASTASSYSPPTS 2063

Human  1982 ISNIAFYNKTNNAQNGHLLEDDYYS-PH----GMLANGSR--GDLLERVSQASSYPDVKVARTLP 2039
            :.|||:|||||||||||:||::||| |.    |.||||..  .||||||||..:|.|||||||:|
Zfish  2064 LGNIAYYNKTNNAQNGHMLEEEYYSQPQPSSLGKLANGGARDRDLLERVSQVPTYQDVKVARTMP 2128

Human  2040 VAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV 2075
            ||||||:|:|||||||:|||.|||||||||||||||
Zfish  2129 VAQAYQENMYRQLSRDARQGPTSPIKPKRPFVESNV 2164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TANC2	XP_011522899.1	PHA03095	930..>1224	CDD:222980	244/380 (64%)
		ANK repeat	963..989	CDD:293786	17/25 (68%)
		ANK repeat	991..1022	CDD:293786	24/30 (80%)
		ANKYR	1100..1299	CDD:440430	175/198 (88%)
		ANK repeat	1108..1138	CDD:293786	27/29 (93%)
		ANK repeat	1140..1171	CDD:293786	24/30 (80%)
		ANK repeat	1174..1204	CDD:293786	24/29 (83%)
		ANK repeat	1206..1237	CDD:293786	27/30 (90%)
		ANK repeat	1239..1270	CDD:293786	26/30 (87%)
		ANK repeat	1272..1302	CDD:293786	28/29 (97%)
		TPR repeat	1331..1356	CDD:276809	22/24 (92%)
		TPR	1335..>1450	CDD:440225	104/114 (91%)
		TPR repeat	1361..1404	CDD:276809	38/42 (90%)
		TPR repeat	1409..1438	CDD:276809	23/28 (82%)
		PHA03247	<1512..1741	CDD:223021	134/244 (55%)
tanc2b	XP_073774149.1	None