DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TANC2 and trp-4

DIOPT Version :10

Sequence 1:XP_011522899.1 Gene:TANC2 / 26115 HGNCID:30212 Length:2075 Species:Homo sapiens
Sequence 2:NP_493429.2 Gene:trp-4 / 190574 WormBaseID:WBGene00006616 Length:1924 Species:Caenorhabditis elegans


Alignment Length:1457 Identity:306/1457 - (21%)
Similarity:496/1457 - (34%) Gaps:468/1457 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   169 GFLLGEKVTEVQPG-------DQYSMEVQDENQTSAITQRISPCSTLTSSTASP-PASSPCSTLP 225
            |.:||..:.|....       |...:.|:..|:....::|    :.:...|:.| |:......:|
 Worm     6 GGILGRALREASQSTRQENDVDMDQVPVRQMNRDYGGSRR----TQMNPHTSQPGPSHVSIVNVP 66

Human   226 ----PISTNATAKDCSYGA-----------------VTS----------PTSTLESRDSGIIATL 259
                |.|:.:|..:..:.|                 ||:          ||.|..|..|    |:
 Worm    67 ERGGPTSSTSTTHETEHTAHRTESGRFIRRRRQSREVTTTTTRPYDPAPPTQTRTSSGS----TV 127

Human   260 TSYSENVERTKYAGESSK-ELGSGGNI---------------KPWQSQKSSMDSCLYRVDENMTA 308
            ..:.||  |.|.|.|..| ...|||.|               :....:.|:....|....::|..
 Worm   128 NGWGEN--RPKSADEEIKRRRRSGGGILSRGLREMNKMVEELEQASEEPSTRKGILGTALKDMEG 190

Human   309 STYSLNKIPERNLET----------VLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLD--EQR 361
            :||  .||..:..||          .:|..|..|...|  |...........|.||...|  ...
 Worm   191 TTY--QKIYRKREETPKRSRSFDDQEMSNRVGMIEHLL--RDKDPLELQQLGLTDLLTTDTIPTD 251

Human   362 HTPLR---TSLRMPRQSMGGARTQQDLRVRFAPYR-------PPDISL-KPLLFEVPSITTES-- 413
            ..|||   |.|::.:.|          |:.|.|.:       |||..| |||..|  |:|:.:  
 Worm   252 RPPLRRSSTHLQIGKNS----------RIIFVPKQPSRDSVTPPDRLLGKPLFRE--SLTSHASS 304

Human   414 -------------------VFVGRD-WVFHEIDAQLQSSNASVNQGVVIVGNIGF---------G 449
                               .|..|| |.  .:::::::...|   ...:..|.||         |
 Worm   305 HEEMSSEDLAMADPQTKILYFAKRDEWA--NVESEIETIKRS---DFSMADNHGFTAFLLAVKAG 364

Human   450 KTAIISRLVALSCHGTRMRQIASDSPHASPKHVDA------NRELPLTQ----------PP---S 495
            |..|:.:::.   .|.|:.....|..:|:  |:.|      ..||.|.:          |.   :
 Worm   365 KDQIVDKMIR---KGARVDYSTKDGRNAT--HIAAMYSGVETLELILKRYSELLRKGAGPKKQLA 424

Human   496 AHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVH--------NVAAL 552
            .|.:....|....|.::|..|:..:|:|.        ..|.:    :|  :|        |:..|
 Worm   425 IHVACERKSKKAFPIVKRILEDTDQRMAE--------DGDGS----LP--IHLAFKFGNVNIVEL 475

Human   553 LCRSPQLTAYR------EQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLEN-----------L 600
            |...|.....|      :.||.       |:.||   ..:.:.|..:....:|           |
 Worm   476 LLSGPSDEQTRKADGNGDTLLH-------LAARS---GNIEAVRTAIAAGCDNANVQNRVGRTPL 530

Human   601 HKERKIPDEDFIILIDGLN-EAEFH-KPD---------YGDTIVSFLSKMIGKFPSWLKLIVTVR 654
            |:..::.|::.:.::..|. :|..| |.|         .|||  |.:..:|.||..      ::|
 Worm   531 HEVAEVGDQNMLKIMFKLRADANIHDKEDKTPVHVAAERGDT--SMVESLIDKFGG------SIR 587

Human   655 TSLQEITKLLPF-----HR----IFLDRLEENEAIDQDLQAYILHR-----IHSSSEI------- 698
            ...::.:.||..     |.    .||.|         .:..::.::     :||::..       
 Worm   588 ARTRDGSTLLHIAACSGHTSTALAFLKR---------GVPLFMPNKKGALGLHSAAAAGFNDVVK 643

Human   699 -----QNNISLNGKMDNTT-------FGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYK 751
                 ..|:.:..: ||.|       .||.|.....|..|:.:::|..    |.|...|.     
 Worm   644 MLIARGTNVDVRTR-DNYTALHVAVQSGKASVVETLLGSGADIHVKGG----ELGQTALH----- 698

Human   752 VVPVSLSEVYLLQCNMKF------PTQSSFDRVMPLLNVAVAS-----LHPLTDEHIFQAINAGS 805
             :..||:......|.|..      |..:..|. ...|::|..|     :..|.||:....|::..
 Worm   699 -IAASLNGAESRDCAMMLLKSGGQPDVAQMDG-ETCLHIAARSGNKDIMRLLLDENADSKISSKI 761

Human   806 IEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREE-------------------- 850
            .|..|:........|..||.|   :.::.:......:|.:..|..                    
 Worm   762 GETPLQVAAKSCNFEAASMIL---KHLSEVLTQEQLKEHVNHRTNDGFTALHYAAEIEQRQLHFP 823

Human   851 GEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQT-IELGHHILKAHIFKGLSKKVGVSS-SILQGL 913
            ||..|.:      :.|:.:....:...||..:| :.:........:...:..|:|..: .|:|. 
 Worm   824 GEDAKLV------NLLIDYGGMVEMPSLNANETAMHMAARSGNQAVLLAMVNKIGAGAVQIVQN- 881

Human   914 WISYSTEGLSMAL-------ASLRNL-----------------------YTPNIKVSRLLILGGA 948
              ..|..|.|..|       :.:.|:                       :..::.:..||:...|
 Worm   882 --KQSKNGWSPLLEACARGHSGVANILLKHHARIDVFDEMGRTALHLAAFNGHLSLVHLLLQHKA 944

Human   949 NINYRTEVLNNAPI-------------LCVQSHLGYTEMVAL--------------------LLE 980
            .:|.:::. ..||:             :.||.|....|.:.|                    ||.
 Worm   945 FVNSKSKT-GEAPLHLAAQHGHVKVVNVLVQDHGAALEAITLDNQTALHFAAKFGQLAVSQTLLA 1008

Human   981 FGANVDASSESGLTPLGYAAAAGYLSIVVLLCK----KRAKVDHLDKNG-QCALVHAALRGHLEV 1040
            .|||.:|..:.|.|||..||...:..:|.|..|    .|:.:..:|.|| .||.: ||::|.|.|
 Worm  1009 LGANPNARDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCAHI-AAMKGSLAV 1072

Human  1041 VKFLIQCDWTM------------------AGQQQGVFK------------KSHAIQ--------- 1066
            |:.|:..|..|                  ||....:.|            .||.:.         
 Worm  1073 VRELMMIDKPMVIQAKTKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALHLGAKNG 1137

Human  1067 ----------------------QALIAAASMGYTEIVSYLL---DLPEKDEEEVERAQIN-SFDS 1105
                                  .||..||..|.::.|:.:|   ....:.|..:....:| .|.:
 Worm  1138 FISILEAFDKILWKRCSRKTGLNALHIAAFYGNSDFVNEMLKHVQATVRSEPPIYNHHVNKEFST 1202

Human  1106 LWGETALTAAAGRGKLEVCRLLLEQGAAV-AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM 1169
            .:|.|.|..||..|...:.|:||.||..| |.......:||....:|||..:|.:||:.......
 Worm  1203 EYGFTPLHLAAQSGHDSLVRMLLNQGVQVDATSTTMNVIPLHLAAQQGHIAVVGMLLSRSTQQQH 1267

Human  1170 A-DKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1233
            | |.:|||||.:||..||...|..|:|||::|.:||:.|.|.|.:|...||||||:..:|:.|..
 Worm  1268 AKDWRGRTPLHLAAQNGHYEMVSLLIAQGSNINVMDQNGWTGLHFATRAGHLSVVKLFIDSSADP 1332

Human  1234 DHADKNGRTPLDLAAFYGDAEVVQFLV 1260
            ....|.|:.||..||.:...|.::||:
 Worm  1333 LAETKEGKVPLCFAAAHNHIECLRFLL 1359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TANC2XP_011522899.1 PHA03095 930..>1224 CDD:222980 106/421 (25%)
ANK repeat 963..989 CDD:293786 11/45 (24%)
ANK repeat 991..1022 CDD:293786 10/34 (29%)
ANKYR 1100..1299 CDD:440430 63/164 (38%)
ANK repeat 1108..1138 CDD:293786 13/30 (43%)
ANK repeat 1140..1171 CDD:293786 9/31 (29%)
ANK repeat 1174..1204 CDD:293786 15/29 (52%)
ANK repeat 1206..1237 CDD:293786 12/30 (40%)
ANK repeat 1239..1270 CDD:293786 8/22 (36%)
ANK repeat 1272..1302 CDD:293786
TPR repeat 1331..1356 CDD:276809
TPR 1335..>1450 CDD:440225
TPR repeat 1361..1404 CDD:276809
TPR repeat 1409..1438 CDD:276809
PHA03247 <1512..1741 CDD:223021
trp-4NP_493429.2 ANKYR 312..581 CDD:440430 56/304 (18%)
ANK repeat 352..383 CDD:293786 7/33 (21%)
ANK repeat 385..418 CDD:293786 7/34 (21%)
ANK repeat 424..454 CDD:293786 7/37 (19%)
ANK repeat 456..489 CDD:293786 8/38 (21%)
ANKYR 473..766 CDD:440430 62/331 (19%)
ANK repeat 491..523 CDD:293786 7/41 (17%)
ANK repeat 526..556 CDD:293786 5/29 (17%)
ANK repeat 558..590 CDD:293786 9/39 (23%)
ANK repeat 592..623 CDD:293786 6/39 (15%)
ANK repeat 625..656 CDD:293786 3/30 (10%)
ANK repeat 658..688 CDD:293786 8/29 (28%)
ANK repeat 692..726 CDD:293786 7/39 (18%)
ANK repeat 728..753 CDD:293786 7/25 (28%)
Ank_2 733..837 CDD:463710 19/112 (17%)
ANK repeat 761..802 CDD:293786 7/43 (16%)
ANK repeat 804..842 CDD:293786 4/43 (9%)
ANKYR 845..1130 CDD:440430 58/289 (20%)
ANK repeat 849..884 CDD:293786 5/37 (14%)
ANK repeat 886..917 CDD:293786 4/30 (13%)
ANK repeat 919..950 CDD:293786 4/30 (13%)
ANK repeat 952..982 CDD:293786 5/30 (17%)
ANK repeat 986..1017 CDD:293786 6/30 (20%)
ANK repeat 1092..1123 CDD:293786 3/30 (10%)
Ank_2 1097..1234 CDD:463710 27/136 (20%)
ANK repeat 1204..1236 CDD:293786 13/31 (42%)
TRPV 1209..1879 CDD:454755 59/151 (39%)
ANK repeat 1238..1270 CDD:293786 9/31 (29%)
ANK repeat 1272..1303 CDD:293786 15/30 (50%)
ANK repeat 1305..1336 CDD:293786 12/30 (40%)
ANK repeat 1338..1366 CDD:293786 8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

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