DRSC/TRiP Functional Genomics Resources

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Protein Alignment TANC2 and T28D6.4

DIOPT Version :10

Sequence 1:XP_011522899.1 Gene:TANC2 / 26115 HGNCID:30212 Length:2075 Species:Homo sapiens
Sequence 2:NP_499461.1 Gene:T28D6.4 / 176566 WormBaseID:WBGene00012124 Length:991 Species:Caenorhabditis elegans


Alignment Length:898 Identity:214/898 - (23%)
Similarity:339/898 - (37%) Gaps:198/898 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   467 MRQIASDSPH-----ASPKHVDANRELP-LTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQ 525
            |||..|...|     .:|::|..::.|. ..|..|....|......|.....|:..|     .|:
 Worm     1 MRQPLSHGAHGAPLDGAPRNVAMSKFLEWFQQANSRRLEIIGKEHSGKTWFARKLSE-----VSE 60

Human   526 VVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLRE-PHL-QSMLSLRSCVQDPMAS 588
            .||.|:|..|...:...|..:.::.             |||:|. |:| ...|:..:.::|.:::
 Worm    61 CVASHFCSHDEPQSSEPPTVIRSLG-------------EQLMRRFPNLVLPRLTTVTLLEDTVSA 112

Human   589 FRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTV 653
            ....:..|||.:....|    ...::||.:.:.|      ...:|..|.:::   |.|::::.|.
 Worm   113 LDHFLRLPLETMPSTSK----PVFLVIDSVEDEE------TQVLVEMLVEIL---PPWIQIVTTS 164

Human   654 RTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRI-HSSSEIQNNISLNGKMDNTTFGKLS 717
            |......|:||..|            ||.|...:|..:: |...|                    
 Worm   165 RDRTNSETELLELH------------IDSDFDKFIRLKLPHCHVE-------------------- 197

Human   718 SHLKTLSQGSYLYLKLTFDLIEKG----------------YLVLKSSSYKVVPVSLSE-VYLLQC 765
             .::..|.||:.|::.....:|.|                :||.:|     :|.|.:: |.|.:.
 Worm   198 -EVREASDGSWFYVEQLARAVELGMVPSDMVPPIGVEKMMHLVARS-----LPRSFADIVRLAKT 256

Human   766 NMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLE-------WEDFQQRMENLS 823
            :...||:.....|..:|.....|:.......|...|...|.|...|       |  ||       
 Worm   257 SRNRPTRQQLLAVSQMLVSRDISVLEKDIRIITSLIGTASSENPSEIFHVPDIW--FQ------- 312

Human   824 MFLIKRRDMTRMFVHPSFREWLIWREEGEKTK------FLCDPRSGHTLLAFWFSRQ-EGKLNRQ 881
                       :....:||....|.|. .|||      .:|:       ||:..|.. ...||..
 Worm   313 -----------LIGEENFRCHTAWAEH-YKTKRRKSAQDICE-------LAYHLSHSTTNPLNAV 358

Human   882 QTIE---LGHHILKAHIF----KGLSKKVGV-----SSSILQGLWISYSTEGLSMALASLRNLYT 934
            :|::   .|:.:|:.|:.    ..|.|..|.     :..::    .:.|...:|...|.||.:..
 Worm   359 KTLQSVGAGNLVLRCHVIDLPTTALLKSAGARMEENNYDVV----YACSVGDVSYLDAILREMKP 419

Human   935 PNIKVSRLLILGGA--NINYRTEVLNNAPILCVQS------------HLGYTEMVALLLEFGANV 985
            ..:.:...|:...|  ||.....:.::.|.|...|            ..|..|::.||||.|.:|
 Worm   420 VPMDICFGLLTAAARGNIEMCRFLADHFPHLVASSCCGEWNALRSAACYGQLEILHLLLEKGVDV 484

Human   986 DASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWT 1050
            |....|..|.|..||.:|.|:.|.||.:..|:||..|...:.||:.||...|.:||..:||    
 Worm   485 DECGHSDRTALRAAAWSGQLAAVQLLLQTGAEVDRRDSEQRTALMAAAFMCHKDVVSVIIQ---- 545

Human  1051 MAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQI----NS---FDSLWG 1108
             .|.......||.|  .||....|.|            .|.||..|..::    |:   .:...|
 Worm   546 -YGADVNAIDKSGA--TALHLNLSNG------------SKQEENSETTKLLLEHNADCKIEDANG 595

Human  1109 ETALTAAAGRGKLEVC-RLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLL-THGADVNMAD 1171
            ..||..||..|  :.| :|:||:...|...:..|..||.....||..:.|..|. |..|||:..|
 Worm   596 RVALHLAAYHG--DPCLQLILEKHPIVDVMDNMGQTPLMLAASQGQLEAVQFLTKTAKADVDAID 658

Human  1172 KQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1236
            ..|||.|..||..||...|:||.:.|:.....|.:|..||.:|....|:.:|:.|. |....:..
 Worm   659 NNGRTALQWAAINGHPEVVEFLCSVGSDEGHKDNDGAVALHYAVTHDHVELVKHLT-NQHTVEAK 722

Human  1237 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1289
            |:.|:.|:.:||..|:.:|:::|:....:|...|:.|...|..|....:||::
 Worm   723 DRYGQHPMMIAAANGNLKVLEYLMGISDIINQPDHEGRTALSLASMAAHTSII 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TANC2XP_011522899.1 PHA03095 930..>1224 CDD:222980 94/316 (30%)
ANK repeat 963..989 CDD:293786 11/37 (30%)
ANK repeat 991..1022 CDD:293786 13/30 (43%)
ANKYR 1100..1299 CDD:440430 60/199 (30%)
ANK repeat 1108..1138 CDD:293786 11/30 (37%)
ANK repeat 1140..1171 CDD:293786 11/31 (35%)
ANK repeat 1174..1204 CDD:293786 12/29 (41%)
ANK repeat 1206..1237 CDD:293786 8/30 (27%)
ANK repeat 1239..1270 CDD:293786 8/30 (27%)
ANK repeat 1272..1302 CDD:293786 5/18 (28%)
TPR repeat 1331..1356 CDD:276809
TPR 1335..>1450 CDD:440225
TPR repeat 1361..1404 CDD:276809
TPR repeat 1409..1438 CDD:276809
PHA03247 <1512..1741 CDD:223021
T28D6.4NP_499461.1 ANKYR 410..713 CDD:440430 97/323 (30%)
ANK repeat 428..454 CDD:293786 6/25 (24%)
ANK repeat 459..488 CDD:293786 9/28 (32%)
ANK repeat 490..521 CDD:293786 13/30 (43%)
ANK repeat 523..554 CDD:293786 10/35 (29%)
ANK repeat 556..592 CDD:293786 11/49 (22%)
ANK repeat 594..624 CDD:293786 11/31 (35%)
ANK repeat 626..658 CDD:293786 11/31 (35%)
ANK repeat 660..691 CDD:293786 12/30 (40%)
ANKYR 706..946 CDD:440430 19/71 (27%)
ANK repeat 725..756 CDD:293786 8/30 (27%)
ANK repeat 824..856 CDD:293786
ANK repeat 858..890 CDD:293786
ANK repeat 892..923 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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