Protein Alignment TANC2 and tanc2

DIOPT Version :10

• Sequence 1: XP_011522899.1
• Gene: TANC2 / 26115
• HGNCID: 30212
• Length: 2075
• Species: Homo sapiens
• Sequence 2: XP_031750132.1
• Gene: tanc2 / 100485280
• XenbaseID: XB-GENE-855813
• Length: 2061
• Species: Xenopus tropicalis
• Alignment Length: 2091
• Identity: 1784/2091 - (85%)
• Similarity: 1910/2091 - (91%)
• Gaps: 46/2091 - (2%)

Human     1 MFRNSLKMLLTGGKSSRKNRSSDGGSEE-PPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVP 64
            ||||||||||:||||:|||||||||||| ...|||.|||||..|:.|||.|:|:||||||||::.
 Frog     1 MFRNSLKMLLSGGKSNRKNRSSDGGSEELQESRRQHSVDSRHGRAAQGGSSSENDCAFEPDYSIN 65

Human    65 PLPVSEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSP 129
            ||||:|||||||:|||||||||||||||||:||||||||||||.|||||||||||||||||||||
 Frog    66 PLPVTEGMQHIRMMEGMSRSLPSSPLLTHQAISVRLQPVKKLTDPLRKAKFVESPRIPESELGSP 130

Human   130 TLTSAQKLDVDAYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPG-DQYSMEVQDEN 193
            ||.|.|.|:.|||..|:.|..||||||||||||||||||||||||||:|||.. .|||||.|:||
 Frog   131 TLGSTQNLEADAYLLGEDESVLGPPPSVDEAANTLMTRLGFLLGEKVSEVQAAVPQYSMEGQEEN 195

Human   194 QT----------SAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTL 248
            |.          ||:||||||||||||||||||||||||||||.:|.|.||||      ||||||
 Frog   196 QVREDWQEDKQGSAVTQRISPCSTLTSSTASPPASSPCSTLPPPNTTAPAKDC------SPTSTL 254

Human   249 ESRDSGIIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSL 313
            |||||||||||||||||::|:||..||.|:.|:.|.:|  |:|| ||||||||||||:.|||:||
 Frog   255 ESRDSGIIATLTSYSENMDRSKYGAESGKDGGTRGCVK--QAQK-SMDSCLYRVDENIMASTFSL 316

Human   314 NKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGG 378
            ||||||.|:|.||||||||||||||||||||||||||||||||||||||||||||||||||::.|
 Frog   317 NKIPERGLDTALSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQTLAG 381

Human   379 ARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIV 443
            .||.|||||||||||||||||||||||||||||:::||||||:||||||||||.:.:||:||||.
 Frog   382 PRTPQDLRVRFAPYRPPDISLKPLLFEVPSITTDTMFVGRDWLFHEIDAQLQSEDDAVNRGVVIC 446

Human   444 GNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGT 508
            |||||||||||||||||||||||||||.||||||||||.:||||  |:||...||.|||||||||
 Frog   447 GNIGFGKTAIISRLVALSCHGTRMRQINSDSPHASPKHSEANRE--LSQPGQTHSGITSGSCPGT 509

Human   509 PEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQ 573
            |||||||||||||:|:|||||||||||||||||||||||||||||||:|.|.|||||||||||||
 Frog   510 PEMRRRQEEAMRRIAAQVVAYHYCQADNAYTCLVPEFVHNVAALLCRAPHLVAYREQLLREPHLQ 574

Human   574 SMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSK 638
            |:||||||||||.||||||||||||||:|||||||||:|||||||||||||||||||||||||:|
 Frog   575 SLLSLRSCVQDPAASFRRGVLEPLENLYKERKIPDEDYIILIDGLNEAEFHKPDYGDTIVSFLNK 639

Human   639 MIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNIS 703
            ||||||.||||||||||:||||||.||||||.|||||||||||||||||||.|||||||||||||
 Frog   640 MIGKFPRWLKLIVTVRTTLQEITKQLPFHRISLDRLEENEAIDQDLQAYILQRIHSSSEIQNNIS 704

Human   704 LNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMK 768
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
 Frog   705 LNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMR 769

Human   769 FPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMT 833
            |||||||:|.:||||||||||||||||||||||||||::|.||||||||||||||||||||||:|
 Frog   770 FPTQSSFERALPLLNVAVASLHPLTDEHIFQAINAGSVDGGLEWEDFQQRMENLSMFLIKRRDLT 834

Human   834 RMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKG 898
            ||||||||||||||||:||||||||||||||.|||||||||||||||||||||||||||||||||
 Frog   835 RMFVHPSFREWLIWREDGEKTKFLCDPRSGHILLAFWFSRQEGKLNRQQTIELGHHILKAHIFKG 899

Human   899 LSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPIL 963
            |||||||:|||||.|||||||:||||||||||||||||||||||||..|||:|||||||||||||
 Frog   900 LSKKVGVASSILQALWISYSTDGLSMALASLRNLYTPNIKVSRLLITAGANVNYRTEVLNNAPIL 964

Human   964 CVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCA 1028
            |||:||||||||||||||..|||||||||||||.||||:|:|:||:||||:|||||.||||||||
 Frog   965 CVQAHLGYTEMVALLLEFYVNVDASSESGLTPLSYAAASGHLTIVMLLCKRRAKVDLLDKNGQCA 1029

Human  1029 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEE 1093
            ||||||||||||||:||||||||||||.|:.|||.||||||||||||||:|||||||||||||||
 Frog  1030 LVHAALRGHLEVVKYLIQCDWTMAGQQPGILKKSQAIQQALIAAASMGYSEIVSYLLDLPEKDEE 1094

Human  1094 EVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVD 1158
            |.||||||||||||||||||||||||||:||||||||||||:||||||.||:||.||||||||||
 Frog  1095 EEERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVSQPNRRGVVPIFSAVRQGHWQIVD 1159

Human  1159 LLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVV 1223
            |||||||||||||||||||||.||||||:.||:|||||||||:||||||||:|||||||||||||
 Frog  1160 LLLTHGADVNMADKQGRTPLMTAASEGHVATVEFLLAQGASISLMDKEGLTSLSWACLKGHLSVV 1224

Human  1224 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSV 1288
            |:||::||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
 Frog  1225 RTLVESGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDQGAMIEHVDYSGMRPLDRAVGCRNTSV 1289

Human  1289 VVTLLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQY 1353
            ||.|||||||||||||||||:|||||||||||||||:||||||||||||||||||||||||||||
 Frog  1290 VVALLKKGAKIGCQTLPSRPKGPATWAMATSKPDIMVILLSKLMEEGDMFYKKGKVKEAAQRYQY 1354

Human  1354 ALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARA 1418
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
 Frog  1355 ALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAFYARARA 1419

Human  1419 KRSSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPE 1483
            || |||||.||||||||||:||||||||||||:||||||||::|.::       .|:|.:|.|.|
 Frog  1420 KR-SSRQFTAALEDLNEAIQLCPNNREIQRLLMRVEEECRQLEQEEE-------VQELQDEPEQE 1476

Human  1484 PQHEDIYSVQ-DIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPPHRDSAYISSSPLGS 1547
            .|:|:|.|.| ||:||||||||::.|.:.|.||.||..||..:||||.||.||||||||.
 Frog  1477 VQNEEIDSTQEDIYEEEYLEQDMDTVPVVLPTEVRPCPGLTGMQSPPQSPAHRDSAYISG----- 1536

Human  1548 HQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKE 1612
               |||||:|||||||||:||||||:|||||||||||.||||||||||..||||||||||||..:
 Frog  1537 ---FDFRSNSSVGSPTRQSYQSTSPSLSPTHQNSHYRASPPHTSPAHQSSSYRFSPPPVGGQVMD 1598

Human  1613 YPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMP 1677
            |||||||||||.||||||||:||:|:||..||||||||||..:||||||||||||||:||.:||.
 Frog  1599 YPSPPPSPLRRAPQYRASPPSESISMYRQPSGSPVRYQQEPCISQLPGRPKSPLSKMSQRSFQMS 1663

Human  1678 QLPVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSR 1742
            |||.||||...||||||||||||||||.|||||.||.:|.||||||.||||||:|.|:|  ||||
 Frog  1664 QLPTAVPQPAHRLQPAKAQIVRSNQPSSAVHSSAVISSGTYGQVAHGMASKYQTSSGEI--SQSR 1726

Human  1743 LVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQS 1807
            ||||.|:||::.|||||||||||||||||||. ...|:|:||||:||||||:||:||||||||||
 Frog  1727 LVYQASLGGLLPDGRPVQHVQASLSAGAICQQ-TFPKDDIPQRPTSAYRGGMRYNQTPQIGRSQS 1790

Human  1808 ASYYPVCHSKLDLERS---SSQLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSP 1869
            |||||||||||:|||:   |||||||:||||||||:|:|||||||||||||||||||||||||||
 Frog  1791 ASYYPVCHSKLELERTSLPSSQLGSPEVSHLIRRPVSINPNEIKPHPPTPRPLLHSQSVGLRFSP 1855

Human  1870 SSNSISSTSNLTPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGII 1934
            |||||||:|:|:..||||:|||||||||||||||.|||||||||.||.||:||||||||||||||
 Frog  1856 SSNSISSSSSLSANFRPSASIQQMEIPLKPAYERLCDELSPVSPPQGTYPNEPTRSRTTPFMGII 1920

Human  1935 DKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHL 1999
            |||||||||||.||.:|.||||||||||||||||.|||.||||||||||||||||||||||||||
 Frog  1921 DKTARTQQYPHHHQTSRPWAVSSVDTVLSPTSPGILPQQESFSPPSSISNIAFYNKTNNAQNGHL 1985

Human  2000 LEDDYYSPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPI 2064
            ||||||||||:|.|||||||||||:||||||||||||||||||||||||||||||||||||||||
 Frog  1986 LEDDYYSPHGVLPNGSRGDLLERVTQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPI 2050

Human  2065 KPKRPFVESNV 2075
            |||||||||||
 Frog  2051 KPKRPFVESNV 2061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TANC2	XP_011522899.1	PHA03095	930..>1224	CDD:222980	262/293 (89%)
		ANK repeat	963..989	CDD:293786	22/25 (88%)
		ANK repeat	991..1022	CDD:293786	23/30 (77%)
		ANKYR	1100..1299	CDD:440430	182/198 (92%)
		ANK repeat	1108..1138	CDD:293786	27/29 (93%)
		ANK repeat	1140..1171	CDD:293786	27/30 (90%)
		ANK repeat	1174..1204	CDD:293786	24/29 (83%)
		ANK repeat	1206..1237	CDD:293786	26/30 (87%)
		ANK repeat	1239..1270	CDD:293786	29/30 (97%)
		ANK repeat	1272..1302	CDD:293786	28/29 (97%)
		TPR repeat	1331..1356	CDD:276809	24/24 (100%)
		TPR	1335..>1450	CDD:440225	110/114 (96%)
		TPR repeat	1361..1404	CDD:276809	42/42 (100%)
		TPR repeat	1409..1438	CDD:276809	25/28 (89%)
		PHA03247	<1512..1741	CDD:223021	173/228 (76%)
tanc2	XP_031750132.1	PHA03095	931..>1226	CDD:222980	263/294 (89%)
		ANK repeat	964..990	CDD:293786	22/25 (88%)
		ANK repeat	992..1023	CDD:293786	23/30 (77%)
		ANKYR	1081..1300	CDD:440430	201/218 (92%)
		ANK repeat	1109..1139	CDD:293786	27/29 (93%)
		ANK repeat	1141..1172	CDD:293786	27/30 (90%)
		ANK repeat	1175..1205	CDD:293786	24/29 (83%)
		ANK repeat	1207..1238	CDD:293786	26/30 (87%)
		ANK repeat	1240..1271	CDD:293786	29/30 (97%)
		ANK repeat	1273..1303	CDD:293786	28/29 (97%)
		TPR repeat	1332..1357	CDD:276809	24/24 (100%)
		TPR	1336..>1450	CDD:440225	110/114 (96%)
		TPR repeat	1362..1405	CDD:276809	42/42 (100%)
		TPR repeat	1410..1438	CDD:276809	25/28 (89%)
		Atrophin-1	1521..>1969	CDD:460830	371/458 (81%)