Protein Alignment PYGO1 and pygo1

DIOPT Version :10

• Sequence 1: NP_056432.1
• Gene: PYGO1 / 26108
• HGNCID: 30256
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_001107109.1
• Gene: pygo1 / 797729
• ZFINID: ZDB-GENE-080204-62
• Length: 337
• Species: Danio rerio
• Alignment Length: 400
• Identity: 180/400 - (45%)
• Similarity: 220/400 - (55%)
• Gaps: 86/400 - (21%)

Human    15 SHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTI 79
            :.||::|||.|.|||:.|||||||:||::||.|.|.|||||||||||::|||:|||||||||  |
Zfish    15 NRGGEAGLDVLAGPGLLLGSPDKKRRKSSTQAPPFSPLSEYAPPPNPSADHLIAANPFDDNY--I 77

Human    80 SYKPLPSSNPYLGPG-YPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRP 143
            |    ||..||.|.. ||....|.:.|||        ||| || :::.||..|.|||  .||:|.
Zfish    78 S----PSLKPYFGHSHYPASNSYGSSRMP--------SPY-GP-TIQTQPQYFSQNP--TGFSRT 126

Human   144 HAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVS---NPD--LASN 203
            |.||:.|:...:|...|.||        .|.||  ...|:..|||.||.:|.|   |||  ...|
Zfish   127 HRFNYSPNYVHAFCGGSNNN--------NNMHF--GSVEHGDQIPLQNLNQRSPGFNPDANTTRN 181

Human   204 FVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQ 268
            ..| |.:|||   :||                 .|||.::.|.|..:.|       :|.::...|
Zfish   182 MSP-NLNNFT---QSN-----------------TKQDHSEAANKKYSHN-------VNCEENATQ 218

Human   269 SNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHG 333
            .|.......:.|.|...|:...|               |...|.|.      :.||..   .|..
Zfish   219 DNKTKGGPEKLNGVFHSNNEKKS---------------PDYRRSAL------RMNKVK---RRST 259

Human   334 HSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMAD 398
            .|||:||:|||||.|||||||:||||||||||||||:|||||||||.|||||.||||||||||.|
Zfish   260 SSSSEPVFPCGICLNEVNDDQEAILCEASCQKWFHRVCTGMTETAYNLLTAETSAVWGCDTCMED 324

Human   399 KDVQLMRTRE 408
            ::||:|:..:
Zfish   325 REVQMMKNSD 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PYGO1	NP_056432.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		33/48 (69%)
		Nuclear localization signal. /evidence=ECO:0000255	35..41		4/5 (80%)
		PTZ00395	<145..>357	CDD:185594	65/216 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..338		42/167 (25%)
		PHD_PYGO1	341..397	CDD:277105	49/55 (89%)
		Interaction with H3K4me2	341..388		40/46 (87%)
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:18498752	373..391		15/17 (88%)
pygo1	NP_001107109.1	PHD_PYGO1	267..323	CDD:277105	49/55 (89%)