Protein Alignment PYGO1 and Pygo1

DIOPT Version :10

• Sequence 1: NP_056432.1
• Gene: PYGO1 / 26108
• HGNCID: 30256
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_082392.1
• Gene: Pygo1 / 72135
• MGIID: 1919385
• Length: 417
• Species: Mus musculus
• Alignment Length: 419
• Identity: 366/419 - (87%)
• Similarity: 378/419 - (90%)
• Gaps: 2/419 - (0%)

Human     1 MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDH 65
            |.||....|.......||||||||||||.:||||||||||||||||.||||||||||||||||||
Mouse     1 MSAEQDKEPIALKRVRGGDSGLDGLGGPNIQLGSPDKKKRKANTQGSSFPPLSEYAPPPNPNSDH 65

Human    66 LVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHP 130
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 LVAANPFDDSYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHP 130

Human   131 FPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQV 195
            ||||||||||||||||||||||||:||||.|||.|:|::|||.|||||..|||||||||||..||
Mouse   131 FPQNPLGMGFNRPHAFNFGPHDNSNFGNPPYNNVLTQDINMPGQHFRQGSAENFSQIPPQNVGQV 195

Human   196 SNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHL 260
            |||||||||.||||||||||||:|||||||||.|||||||.|||||||||||..|||||.|||||
Mouse   196 SNPDLASNFAPGNNSNFTSPLETNHSFIPPPNAFGQAKAPLPKQDFTQGATKTPNQNSSTHPPHL 260

Human   261 NMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKS 325
            ||:|.|||||:|||||||||.| ||||||.|.|||||: ||||||||||||||||.||.:||.|.
Mouse   261 NMEDPVNQSNVELKNVNRNNVV-QENSRSGSAEATNNH-ANGTQNKPRQPRGAADLCTPDKSRKF 323

Human   326 SLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVW 390
            ||.|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   324 SLLPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVW 388

Human   391 GCDTCMADKDVQLMRTRETFGPSAVGSDA 419
            ||||||||||||||||||.|||.|||.||
Mouse   389 GCDTCMADKDVQLMRTREAFGPPAVGGDA 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PYGO1	NP_056432.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		47/62 (76%)
		Nuclear localization signal. /evidence=ECO:0000255	35..41		5/5 (100%)
		PTZ00395	<145..>357	CDD:185594	177/211 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..338		135/162 (83%)
		PHD_PYGO1	341..397	CDD:277105	55/55 (100%)
		Interaction with H3K4me2	341..388		46/46 (100%)
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:18498752	373..391		17/17 (100%)
Pygo1	NP_082392.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		54/69 (78%)
		Nuclear localization signal. /evidence=ECO:0000255	35..41		5/5 (100%)
		Atrophin-1	56..>265	CDD:460830	188/208 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..265		77/89 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..318		29/34 (85%)
		PHD_PYGO1	339..395	CDD:277105	55/55 (100%)
		Interaction with H3K4me2. /evidence=ECO:0000250	339..386		46/46 (100%)
		Interaction with BCL9. /evidence=ECO:0000250	371..389		17/17 (100%)