Protein Alignment PYGO1 and lgs

DIOPT Version :10

• Sequence 1: NP_056432.1
• Gene: PYGO1 / 26108
• HGNCID: 30256
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_651922.1
• Gene: lgs / 43791
• FlyBaseID: FBgn0039907
• Length: 1469
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 113/521 - (21%)
• Similarity: 158/521 - (30%)
• Gaps: 186/521 - (35%)

Human     5 NSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPS--FPPLSEYAPPPNPNSDHLV 67
            ||...|||            :|...:|:      :|:|:.||.|  |...|:.. |.||||.:..
  Fly   943 NSALNAYK------------MGSTNIQM------ERQASAQGGSVQFSRRSDNI-PLNPNSGNRP 988

Human    68 AANPFDDNYNTIS-----YKPLPSSNPYLG-PGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRN 126
            ..|....|::.||     .:.|.|....:| |.  |.||.:          .|..|  ||..: |
  Fly   989 PPNKMTQNFDPISSLAQMSQQLTSCVSSMGSPA--GTGGMT----------MMGGP--GPSDI-N 1038

Human   127 QPHPFPQNPLGMGF-----NRPHAFN-----FGPHDNSSFGNPSY------NNALSQNVNMPNQH 175
            ..|.......|.|.     |..|:.|     .||.    ..||..      |.....|.|.||..
  Fly  1039 IEHGIISGLDGSGIDTINQNNCHSMNVVMNSMGPR----MLNPKMCVAGGPNGPPGFNPNSPNGG 1099

Human   176 FRQNP---------AENFSQIPPQNASQVSN--PDLASNFVP------------------GNNSN 211
            .|:|.         :.||..:.|..|..:..  .:..|||.|                  ..|:|
  Fly  1100 LRENSIGSGCGSANSSNFQGVVPPGARMMGRMPVNFGSNFNPNIQVKASTPNTIQYMPVRAQNAN 1164

Human   212 FTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPH----------------- 259
            ..:...:|:..:||...|.|..|.|     ..||..|   .|...||.
  Fly  1165 NNNNNGANNVRMPPSLEFLQRYANP-----QMGAVGN---GSPICPPSASDGTPGMPGLMAGPGA 1221

Human   260 ----LNMDDTVNQSNIELKNVNRNNAVN--QENSRSSSTEATNNNPA-NGTQN--KPRQPRGAAD 315
                :|.....:|:.| ..|...:|.:|  |..::.|..:.....|. :|:.|  :|...||
  Fly  1222 GGMLMNSSGEQHQNKI-TNNPGASNGINFFQNCNQMSIVDEEGGLPGHDGSMNIGQPSMIRG--- 1282

Human   316 ACTTEKSNKSSLHPNRHG------------HSSSDPVYPCGICTNEVNDDQDAILCEASCQ---- 364
                  ....::.||..|            ..|||.:...|        |..:....|||.
  Fly  1283 ------MRPHAMRPNVMGARMPPVNRQIQFAQSSDGIDCVG--------DPSSFFTNASCNSAGP 1333

Human   365 ------------KWFH--RICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAV 415
                        |..|  .|.:||.:...||..|:.             .:||.......|.|.:
  Fly  1334 HMFGSAQQANQPKTQHIKNIPSGMCQNQSGLAVAQG-------------QIQLHGQGHAQGQSLI 1385

Human   416 G 416
            |
  Fly  1386 G 1386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PYGO1	NP_056432.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		18/60 (30%)
		Nuclear localization signal. /evidence=ECO:0000255	35..41		0/5 (0%)
		PTZ00395	<145..>357	CDD:185594	57/289 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..338		43/229 (19%)
		PHD_PYGO1	341..397	CDD:277105	13/73 (18%)
		Interaction with H3K4me2	341..388		13/64 (20%)
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:18498752	373..391		5/17 (29%)
lgs	NP_651922.1	BCL9	521..557	CDD:431912
		ROM1	764..>995	CDD:227709	20/70 (29%)