DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRIT1 and kek1

DIOPT Version :9

Sequence 1:	NP_056428.1	Gene:	LRIT1 / 26103	HGNCID:	23404	Length:	623	Species:	Homo sapiens
Sequence 2:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	138/571 - (24%)
Similarity:	211/571 - (36%)	Gaps:	108/571 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    16 PPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT------------------- 61
            |.|.:..|.:.|:|.    ..|.| :||.|.|..:...|..|.|:|
  Fly    83 PAQQQSTCQTVCACK----WKGGK-QTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFI 142

Human    62 -------SRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRL 119
                   .:|.|....|..:..|.|:.|..|.:|.|.:|.|..:.:|.|..:..||||.|..|.:
  Fly   143 RANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHI 207

Human   120 AAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184
            ......|..:.|.|..|||....:..:.|:|...|:.||.|.|:.|:|..|..:.|.:.:.|. |
  Fly   208 HKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLH-G 271

Human   185 IFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELR 249
            |           .|.||||.|||||.|....|  ...|:.:....:....|..:...:|:.|.:.
  Fly   272 I-----------ELHDNPWLCDCRLRDTKLWL--MKRNIPYPVAPVCSGGPERIIDRSFADLHVD 323

Human   250 K--CQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGT--------VH--QE 302
            :  |: ||:.|....:.:.:|..|.:.|.|..||...::| ..|||.|...        :|  ::
  Fly   324 EFACR-PEMLPISHYVEAAMGENASITCRARAVPAANINW-YWNGRLLANNSAFTAYQRIHMLEQ 386

Human   303 VSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGG 367
            |.......:.|.|......||.::.|.|:|..|.:|...:|.|           |..|....:.|
  Fly   387 VEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHV-----------SMRAAGMASLG 440

Human   368 GGEAAAYNNKLVARHVPQI-----------PKPAVLATGPS----VPSTKEELTLEHFQMDALGE 417
            .|:....:..|||..|..:           .:|.|.:..|:    :.|...:.::.:....|.|.
  Fly   441 SGQIVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGN 505

Human   418 LSDGR---AGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPG 479
            .|.|.   |..:.|.::....|.|.|.          :.|::....|.:.|..|.|...|...|
  Fly   506 GSIGGVVIANGAVANIIDGGVVQGGTL----------ERKSSGRGGVPHGVHDQRSANPVQKPP- 559

Human   480 KTRVTITGLLPKTK-YVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLIN 529
                .:|.|...|: |..    .|.|.....|.|..:....:..|...|||
  Fly   560 ----RLTDLPYSTQGYDN----NGSVLSTASCFISPSGSTGNGGNNPDLIN 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRIT1	NP_056428.1	LRR 1	60..81		6/46 (13%)
		leucine-rich repeat	61..84	CDD:275378	7/48 (15%)
		LRR_8	63..143	CDD:290566	25/79 (32%)
		LRR 2	84..105		7/20 (35%)
		leucine-rich repeat	85..132	CDD:275378	14/46 (30%)
		LRR 3	108..129		7/20 (35%)
		LRR_8	131..202	CDD:290566	21/70 (30%)
		LRR_4	131..171	CDD:289563	14/39 (36%)
		LRR 4	132..153		6/20 (30%)
		leucine-rich repeat	133..156	CDD:275378	7/22 (32%)
		LRR 5	156..177		8/20 (40%)
		leucine-rich repeat	157..180	CDD:275378	8/22 (36%)
		leucine-rich repeat	181..205	CDD:275378	8/23 (35%)
		TPKR_C2	201..>240	CDD:301599	12/38 (32%)
		Ig	267..345	CDD:299845	23/87 (26%)
		IG_like	267..345	CDD:214653	23/87 (26%)
		FN3	431..498	CDD:214495	14/67 (21%)
		LRR 6. /evidence=ECO:0000305	571..594
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	43/169 (25%)
		leucine-rich repeat	123..148	CDD:275380	1/24 (4%)
		LRR_8	148..207	CDD:290566	19/58 (33%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	195..255	CDD:290566	20/59 (34%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	7/22 (32%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	14/51 (27%)
		IG_like	338..429	CDD:214653	23/91 (25%)
		Ig	346..426	CDD:143165	21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910