DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRIT1 and kirre

DIOPT Version :9

Sequence 1:NP_056428.1 Gene:LRIT1 / 26103 HGNCID:23404 Length:623 Species:Homo sapiens
Sequence 2:NP_001245505.1 Gene:kirre / 31292 FlyBaseID:FBgn0028369 Length:956 Species:Drosophila melanogaster


Alignment Length:336 Identity:72/336 - (21%)
Similarity:118/336 - (35%) Gaps:66/336 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    57 IPPDTSRLR----LERTAIRRVPGEAFRPLGR--LEQLWLPYNALSELNALMLRGLRRLRELRLP 115
            :||:..::.    |..|..|.:..|.....|:  .|..|     :..|..::.:|:..::|....
  Fly   184 VPPEAPKITQGDYLVTTEDREIELECVSQGGKPAAEITW-----IDGLGNVLTKGIEYVKEPLAD 243

Human   116 GNRLAAFPWAALRDAPKLR----LLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELI- 175
            ..|:.|  .:.|:.|||..    ....||...:.....:|:.|..:.:          .|:.:: 
  Fly   244 SRRITA--RSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKY----------APKVIVS 296

Human   176 VSWAHLETGIFPPGHHPRRVLGLQ--DNPWACDCRLYDLVHLLDGWAPNLAFI--------ETEL 230
            |....|..|..|.|  ...:|..|  .||.....|.:....|:.|.......|        :..:
  Fly   297 VVGGALAGGKIPEG--AEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIV 359

Human   231 RCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPL 295
            :|....:: |.:....:|....||.......|:.:.||.|..:||...|.|.||:.|...|...:
  Fly   360 KCEVVNAV-GKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQV 423

Human   296 NGTVHQ---EVSSDGTSWTLLGLPAVSHLDSGDYICQA--KNF--LGASETVISLIVTEPPTSTE 353
            .|...:   :|||:               .:|.|.|:|  ..|  :||..|   |.|...|..|.
  Fly   424 VGVAAELKLKVSSE---------------TAGRYFCKAVVNGFPEIGAEAT---LYVKRAPIITS 470

Human   354 HSGSPGALWAR 364
            |....|.:..|
  Fly   471 HKVQFGGVGGR 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRIT1NP_056428.1 LRR 1 60..81 4/24 (17%)
leucine-rich repeat 61..84 CDD:275378 4/26 (15%)
LRR_8 63..143 CDD:290566 18/89 (20%)
LRR 2 84..105 3/22 (14%)
leucine-rich repeat 85..132 CDD:275378 9/46 (20%)
LRR 3 108..129 4/20 (20%)
LRR_8 131..202 CDD:290566 14/77 (18%)
LRR_4 131..171 CDD:289563 6/43 (14%)
LRR 4 132..153 4/24 (17%)
leucine-rich repeat 133..156 CDD:275378 4/26 (15%)
LRR 5 156..177 1/21 (5%)
leucine-rich repeat 157..180 CDD:275378 2/23 (9%)
leucine-rich repeat 181..205 CDD:275378 8/25 (32%)
TPKR_C2 201..>240 CDD:301599 7/46 (15%)
Ig 267..345 CDD:299845 24/84 (29%)
IG_like 267..345 CDD:214653 24/84 (29%)
FN3 431..498 CDD:214495
LRR 6. /evidence=ECO:0000305 571..594
kirreNP_001245505.1 Ig 87..183 CDD:299845
IG_like 88..182 CDD:214653
C2-set_2 189..279 CDD:285423 18/96 (19%)
Ig_2 307..379 CDD:290606 13/74 (18%)
I-set 382..462 CDD:254352 26/97 (27%)
IGc2 396..446 CDD:197706 17/64 (27%)
Ig 466..561 CDD:299845 5/16 (31%)
IG_like 478..561 CDD:214653 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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